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Hmox1 Gene Detail
Summary
  • Symbol
    Hmox1
  • Name
    heme oxygenase 1
  • Synonyms
    D8Wsu38e, heme oxygenase 1, Hmox, HO-1, HO1, Hsp32
  • Feature Type
    protein coding gene
  • IDs
    MGI:96163
    NCBI Gene: 15368
  • Alliance
    gene page
  • Transcription Start Sites
    34 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:75820249-75827217 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 35.59 cM, cytoband C1
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    222 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96163
 protein coding gene Chr8:75820246-75827221 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033795
 protein coding gene Chr8:75552530-75559233 (+)
A/J MGP_AJ_G0033777
 protein coding gene Chr8:72578992-72585834 (+)
AKR/J MGP_AKRJ_G0033704
 protein coding gene Chr8:74792091-74800938 (+)
BALB/cJ MGP_BALBcJ_G0033771
 protein coding gene Chr8:72679321-72686163 (+)
C3H/HeJ MGP_C3HHeJ_G0033480
 protein coding gene Chr8:75353080-75359910 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034291
 protein coding gene Chr8:78476857-78486030 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031232
 protein coding gene Chr8:66847315-66854505 (+)
CAST/EiJ MGP_CASTEiJ_G0032809
 protein coding gene Chr8:74631683-74638705 (+)
CBA/J MGP_CBAJ_G0033459
 protein coding gene Chr8:81238432-81245262 (+)
DBA/2J MGP_DBA2J_G0033613
 protein coding gene Chr8:72268021-72274825 (+)
FVB/NJ MGP_FVBNJ_G0033558
 protein coding gene Chr8:71344761-71351950 (+)
LP/J MGP_LPJ_G0033702
 protein coding gene Chr8:75678796-75686567 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033601
 protein coding gene Chr8:83793274-83801379 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034308
 protein coding gene Chr8:74756275-74764620 (+)
PWK/PhJ MGP_PWKPhJ_G0032515
 protein coding gene Chr8:71538037-71545156 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032353
 protein coding gene Chr8:73645396-73654300 (+)
WSB/EiJ MGP_WSBEiJ_G0032924
 protein coding gene Chr8:75064182-75071037 (+)



Homology
more
  • Human Ortholog
    HMOX1, heme oxygenase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMOX1, heme oxygenase 1
  • Synonyms
    bK286B10, HMOX1D, HO-1, HSP32
  • Links
    NCBI Gene ID: 3162
    neXtProt AC: NX_P09601
    UniProt: P09601

  • Chr Location
    22q12.3; chr22:35380361-35394214 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Hmox1 mouse models; 15 with human HMOX1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
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IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    106 phenotypes from 7 alleles in 12 genetic backgrounds
    21 phenotypes from multigenic genotypes
    5 images
    159 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit low serum iron levels, increased hepatic and renal iron, oxidative damage, tissue injury, chronic inflammation, reduced neuronal proliferation, and increased sensitivity to hypoxia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    94
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1185
  • Tissues
    185
  • cDNA Data
    113
  • Literature Summary
    39
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005413 Ensembl Gene Model | MGI Sequence Detail 6969 C57BL/6J ±  kb
    transcript ENSMUST00000005548 Ensembl | MGI Sequence Detail 1569 Not Applicable  
    polypeptide ENSMUSP00000005548 Ensembl | MGI Sequence Detail 289 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 138
      Genomic 15
      cDNA 115
      Primer pair 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10800, MGD-MRK-34114, MGD-MRK-38247, MGI:106420, MGI:109203
    References
    more
    • Summaries
      All 393
      Developmental Gene Expression 39
      Diseases 3
      Gene Ontology 12
      Phenotypes 159
    • Earliest
      J:31021 Kageyama H, et al., Isolation and characterization of a complementary DNA clone for a Mr 32,000 protein which is induced with tumor promoters in BALB/c 3T3 cells. Cancer Res. 1988 Sep 1;48(17):4795-8
    • Latest
      J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory