Hmox1 MGI Mouse Gene Detail - MGI:96163

Symbol

Hmox1
Name

heme oxygenase 1
Synonyms

D8Wsu38e, heme oxygenase 1, Hmox, HO-1, HO1, Hsp32

Feature Type

protein coding gene
IDs

MGI:96163
NCBI Gene: 15368
Alliance

gene page
Transcription Start Sites

34 TSS

Sequence Map

Chr8:75820249-75827217 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 35.59 cM, cytoband C1
Mapping Data

11 experiments

SNPs within 2kb

222 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96163	protein coding gene	Chr8:75820246-75827221 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033795	protein coding gene	Chr8:75552530-75559233 (+)
A/J	MGP_AJ_G0033777	protein coding gene	Chr8:72578992-72585834 (+)
AKR/J	MGP_AKRJ_G0033704	protein coding gene	Chr8:74792091-74800938 (+)
BALB/cJ	MGP_BALBcJ_G0033771	protein coding gene	Chr8:72679321-72686163 (+)
C3H/HeJ	MGP_C3HHeJ_G0033480	protein coding gene	Chr8:75353080-75359910 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034291	protein coding gene	Chr8:78476857-78486030 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031232	protein coding gene	Chr8:66847315-66854505 (+)
CAST/EiJ	MGP_CASTEiJ_G0032809	protein coding gene	Chr8:74631683-74638705 (+)
CBA/J	MGP_CBAJ_G0033459	protein coding gene	Chr8:81238432-81245262 (+)
DBA/2J	MGP_DBA2J_G0033613	protein coding gene	Chr8:72268021-72274825 (+)
FVB/NJ	MGP_FVBNJ_G0033558	protein coding gene	Chr8:71344761-71351950 (+)
LP/J	MGP_LPJ_G0033702	protein coding gene	Chr8:75678796-75686567 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033601	protein coding gene	Chr8:83793274-83801379 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034308	protein coding gene	Chr8:74756275-74764620 (+)
PWK/PhJ	MGP_PWKPhJ_G0032515	protein coding gene	Chr8:71538037-71545156 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032353	protein coding gene	Chr8:73645396-73654300 (+)
WSB/EiJ	MGP_WSBEiJ_G0032924	protein coding gene	Chr8:75064182-75071037 (+)

Human Ortholog

HMOX1, heme oxygenase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HMOX1, heme oxygenase 1
Synonyms

bK286B10, HMOX1D, HO-1, HSP32
Links

HGNC:5013

NCBI Gene ID: 3162

neXtProt AC: NX_P09601

UniProt: P09601
Chr Location

22q12.3; chr22:35380361-35394214 (+) GRCh38

MGI Vertebrate Homology

Hmox1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HMOX1
Protein SuperFamily

Haem_Oase
Gene Tree

Hmox1

Diseases

2 with Hmox1 mouse models; 15 with human HMOX1 associations

Human Disease

Mouse Models

hemochromatosis

IDs

View 1 model

malaria

IDs

View 1 model

abdominal aortic aneurysm

IDs

acute chest syndrome

IDs

adenocarcinoma

IDs

adult respiratory distress syndrome

IDs

chronic obstructive pulmonary disease

IDs

coronary artery disease

IDs

coronary restenosis

IDs

factor VIII deficiency

IDs

hypertension

IDs

intracranial vasospasm

IDs

middle cerebral artery infarction

IDs

pneumonia

IDs

pulmonary emphysema

IDs

pulmonary hypertension

IDs

type 2 diabetes mellitus

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

3 with disease annotations

References

3 with disease annotations

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Phenotype Summary

106 phenotypes from 7 alleles in 12 genetic backgrounds
21 phenotypes from multigenic genotypes
5 images
159 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Endonuclease-mediated

7
Gene trapped

5
Targeted

11
Transgenic

1
Genomic Mutations

1 involving Hmox1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit low serum iron levels, increased hepatic and renal iron, oxidative damage, tissue injury, chronic inflammation, reduced neuronal proliferation, and increased sensitivity to hypoxia.

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All GO Annotations

94
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1185
Tissues

185
cDNA Data

113
Literature Summary

39

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hmox1

ZFIN hmox1a, hmox1b

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All Sequences

58
RefSeq

2
UniProt

4
CCDS

CCDS22423.1

Ensembl

ENSMUSG00000005413 (Evidence)
NCBI Gene

15368

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005413	Ensembl Gene Model \| MGI Sequence Detail	6969	C57BL/6J	± kb
transcript	ENSMUST00000005548	Ensembl \| MGI Sequence Detail	1569	Not Applicable
polypeptide	ENSMUSP00000005548	Ensembl \| MGI Sequence Detail	289	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008644 heme oxygenase 1

(term hierarchy)
EC

1.14.14.18
InterPro Domains

IPR002051 Haem oxygenase

IPR018207 Haem oxygenase conserved site

IPR016053 Haem oxygenase-like

IPR016084 Haem oxygenase-like, multi-helical
GlyGen

P14901 1 site, 1 O-linked glycan (1 site)

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All nucleic 138

Genomic 15

cDNA 115

Primer pair 8

Microarray probesets 4

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MGD-MRK-10800, MGD-MRK-34114, MGD-MRK-38247, MGI:106420, MGI:109203

Summaries

All 393

Developmental Gene Expression 39

Diseases 3

Gene Ontology 12

Phenotypes 159
Earliest

J:31021 Kageyama H, et al., Isolation and characterization of a complementary DNA clone for a Mr 32,000 protein which is induced with tumor promoters in BALB/c 3T3 cells. Cancer Res. 1988 Sep 1;48(17):4795-8
Latest

J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893

TSS for Hmox1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78044	Chr8:75820240-75820257 (+)	0 bp
Tssr78045	Chr8:75820798-75820817 (+)	559 bp
Tssr78046	Chr8:75821090-75821101 (+)	847 bp
Tssr78047	Chr8:75821182-75821192 (+)	938 bp
Tssr78048	Chr8:75822463-75822555 (+)	2,260 bp
Tssr78049	Chr8:75823467-75823504 (+)	3,237 bp
Tssr78050	Chr8:75823508-75823531 (+)	3,271 bp
Tssr78051	Chr8:75823536-75823566 (+)	3,302 bp
Tssr78052	Chr8:75823633-75823646 (+)	3,391 bp
Tssr78053	Chr8:75823694-75823705 (+)	3,451 bp
Tssr78054	Chr8:75823720-75823731 (+)	3,477 bp
Tssr78055	Chr8:75823758-75823769 (+)	3,515 bp
Tssr78056	Chr8:75823788-75823800 (+)	3,545 bp
Tssr78057	Chr8:75823815-75823842 (+)	3,580 bp
Tssr78058	Chr8:75823843-75823852 (+)	3,599 bp
Tssr78059	Chr8:75823854-75823859 (+)	3,608 bp
Tssr78060	Chr8:75823862-75823873 (+)	3,619 bp
Tssr78061	Chr8:75823934-75823946 (+)	3,691 bp
Tssr78062	Chr8:75825385-75825464 (+)	5,176 bp
Tssr78063	Chr8:75826505-75826516 (+)	6,262 bp
Tssr78064	Chr8:75826535-75826577 (+)	6,307 bp
Tssr78065	Chr8:75826584-75826599 (+)	6,343 bp
Tssr78066	Chr8:75826634-75826644 (+)	6,390 bp
Tssr78067	Chr8:75826664-75826677 (+)	6,422 bp
Tssr78068	Chr8:75826703-75826715 (+)	6,460 bp
Tssr78069	Chr8:75826748-75826766 (+)	6,508 bp
Tssr78070	Chr8:75826797-75826811 (+)	6,555 bp
Tssr78071	Chr8:75826846-75826865 (+)	6,607 bp
Tssr78072	Chr8:75826867-75826880 (+)	6,625 bp
Tssr78073	Chr8:75826928-75826950 (+)	6,690 bp
Tssr78074	Chr8:75826980-75827004 (+)	6,743 bp
Tssr78075	Chr8:75827005-75827013 (+)	6,760 bp
Tssr78076	Chr8:75827044-75827058 (+)	6,802 bp
Tssr78077	Chr8:75827136-75827153 (+)	6,896 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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