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Hoxa5 Gene Detail
Summary
  • Symbol
    Hoxa5
  • Name
    homeobox A5
  • Synonyms
    Hox-1.3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96177
    NCBI Gene: 15402
  • Member of
    Hoxa cluster
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:52178768-52181437 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 25.40 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    62 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96177
 protein coding gene Chr6:52178734-52181567 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030744
 protein coding gene Chr6:51441543-51444385 (-)
A/J MGP_AJ_G0030713
 protein coding gene Chr6:49037608-49040441 (-)
AKR/J MGP_AKRJ_G0030640
 protein coding gene Chr6:50744067-50746904 (-)
BALB/cJ MGP_BALBcJ_G0030725
 protein coding gene Chr6:49398310-49401143 (-)
C3H/HeJ MGP_C3HHeJ_G0030438
 protein coding gene Chr6:50753150-50755984 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031180
 protein coding gene Chr6:52579216-52582049 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028387
 protein coding gene Chr6:46685360-46688180 (-)
CAST/EiJ MGP_CASTEiJ_G0029841
 protein coding gene Chr6:50566929-50569763 (-)
CBA/J MGP_CBAJ_G0030412
 protein coding gene Chr6:54776210-54779043 (-)
DBA/2J MGP_DBA2J_G0030562
 protein coding gene Chr6:48960021-48962850 (-)
FVB/NJ MGP_FVBNJ_G0030514
 protein coding gene Chr6:48569820-48572653 (-)
LP/J MGP_LPJ_G0030647
 protein coding gene Chr6:51421656-51424495 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030548
 protein coding gene Chr6:57408042-57410870 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031210
 protein coding gene Chr6:50672731-50675562 (-)
PWK/PhJ MGP_PWKPhJ_G0029554
 protein coding gene Chr6:48583638-48586571 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029388
 protein coding gene Chr6:50007937-50010775 (-)
WSB/EiJ MGP_WSBEiJ_G0029918
 protein coding gene Chr6:50688882-50691722 (-)



Homology
more
  • Human Ortholog
    HOXA5, homeobox A5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXA5, homeobox A5
  • Synonyms
    HOX1, HOX1.3, HOX1C
  • Links
    NCBI Gene ID: 3202
    neXtProt AC: NX_P20719
    UniProt: P20719

  • Chr Location
    7p15.2; chr7:27141052-27143681 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 4 alleles in 8 genetic backgrounds
    16 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show skeletal defects, tracheal dysmorphology, reduced surfactant production, emphysema, and partial neonatal lethality. Survivors show stunted growth, delayed ear elevation and eyelid opening, and altered thyroid development, digestive secretion, and ovarian biology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1648
  • Tissues
    304
  • cDNA Data
    26
  • Literature Summary
    115
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15402 NCBI Gene Model | MGI Sequence Detail 2670 C57BL/6J ±  kb
    transcript NM_010453 RefSeq | MGI Sequence Detail 1713 ZRU/MplStud  
    polypeptide P09021 UniProt | EBI | MGI Sequence Detail 270 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 22
      cDNA 28
      Primer pair 15
      Other 19

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10819, MGD-MRK-10878
    References
    more
    • Summaries
      All 193
      Developmental Gene Expression 115
      Gene Ontology 18
      Phenotypes 51
    • Earliest
      J:8127 Colberg-Poley AM, et al., Clustered homeo boxes are differentially expressed during murine development. Cell. 1985 Nov;43(1):39-45
    • Latest
      J:354191 Kc R, et al., Multimodal Hox5 activity generates motor neuron diversity. Commun Biol. 2024 Sep 17;7(1):1166
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory