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Hoxb2 Gene Detail
Summary
  • Symbol
    Hoxb2
  • Name
    homeobox B2
  • Synonyms
    Hox-2.8, Hoxbes2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96183
    NCBI Gene: 103889
  • Member of
    Hoxb cluster
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:96242458-96244846 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.85 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96183
 protein coding gene Chr11:96241351-96244846 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019008
 protein coding gene Chr11:98663614-98667132 (+)
A/J MGP_AJ_G0018976
 protein coding gene Chr11:94635000-94638477 (+)
AKR/J MGP_AKRJ_G0018946
 protein coding gene Chr11:97561794-97565347 (+)
BALB/cJ MGP_BALBcJ_G0018949
 protein coding gene Chr11:95134487-95138548 (+)
C3H/HeJ MGP_C3HHeJ_G0018763
 protein coding gene Chr11:97692438-97695944 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019401
 protein coding gene Chr11:101744564-101748118 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017031
 protein coding gene Chr11:92121804-92125286 (+)
CAST/EiJ MGP_CASTEiJ_G0018316
 protein coding gene Chr11:98517959-98521433 (+)
CBA/J MGP_CBAJ_G0018734
 protein coding gene Chr11:105909240-105912717 (+)
DBA/2J MGP_DBA2J_G0018842
 protein coding gene Chr11:94202443-94205934 (+)
FVB/NJ MGP_FVBNJ_G0018831
 protein coding gene Chr11:93681077-93684562 (+)
LP/J MGP_LPJ_G0018912
 protein coding gene Chr11:99199533-99203022 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018858
 protein coding gene Chr11:105904624-105908120 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019441
 protein coding gene Chr11:97868624-97872111 (+)
PWK/PhJ MGP_PWKPhJ_G0018088
 protein coding gene Chr11:95154467-95158069 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017877
 protein coding gene Chr11:97596162-97599645 (+)
WSB/EiJ MGP_WSBEiJ_G0018366
 protein coding gene Chr11:97758544-97762046 (+)



Homology
more
  • Human Ortholog
    HOXB2, homeobox B2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXB2, homeobox B2
  • Synonyms
    HOX2, Hox-2.8, HOX2H, K8
  • Links
    NCBI Gene ID: 3212
    neXtProt AC: NX_P14652
    UniProt: P14652

  • Chr Location
    17q21.32; chr17:48540894-48545109 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 6 alleles in 4 genetic backgrounds
    10 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele die neonatally with altered segmental identity and abnormal migration of motor neurons in the hindbrain. Mice homozygous for null alleles can exhibit partial postnatal lethality, narrow face, runting, absent facial motor nuclei, and facial nerve/muscle defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1056
  • Tissues
    160
  • cDNA Data
    17
  • Literature Summary
    60
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 103889 NCBI Gene Model | MGI Sequence Detail 2389 C57BL/6J ±  kb
    transcript NM_134032 RefSeq | MGI Sequence Detail 1631 ZRU/MplStud  
    polypeptide P0C1T1 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 4
      cDNA 21
      Primer pair 5
      Other 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10836, MGD-MRK-10884, MGI:2144329
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 60
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:32270 Wilkinson DG, et al., Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain. Nature. 1989 Oct 5;341(6241):405-9
    • Latest
      J:333802 Singh N, et al., LHX2 in germ cells control tubular organization in the developing mouse testis. Exp Cell Res. 2023 Feb 14;425(1):113511
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory