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Hoxd10 Gene Detail
Summary
  • Symbol
    Hoxd10
  • Name
    homeobox D10
  • Synonyms
    Hox-4.5, Hox-5.3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96202
    NCBI Gene: 15430
  • Member of
    Hoxd cluster
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:74522268-74525449 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 44.13 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96202
 protein coding gene Chr2:74514617-74525450 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025848
 protein coding gene Chr2:75006128-75009281 (+)
A/J MGP_AJ_G0025826
 protein coding gene Chr2:72073253-72076406 (+)
AKR/J MGP_AKRJ_G0025794
 protein coding gene Chr2:74026475-74029626 (+)
BALB/cJ MGP_BALBcJ_G0025820
 protein coding gene Chr2:72259893-72263046 (+)
C3H/HeJ MGP_C3HHeJ_G0025580
 protein coding gene Chr2:74214287-74217468 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026267
 protein coding gene Chr2:77240253-77243422 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023670
 protein coding gene Chr2:69496403-69499628 (+)
CAST/EiJ MGP_CASTEiJ_G0025044
 protein coding gene Chr2:74531284-74534454 (+)
CBA/J MGP_CBAJ_G0025561
 protein coding gene Chr2:80061402-80064571 (+)
DBA/2J MGP_DBA2J_G0025692
 protein coding gene Chr2:71679800-71682963 (+)
FVB/NJ MGP_FVBNJ_G0025654
 protein coding gene Chr2:71069518-71072671 (+)
LP/J MGP_LPJ_G0025780
 protein coding gene Chr2:74870261-74873414 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025685
 protein coding gene Chr2:81975038-81978191 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026324
 protein coding gene Chr2:74141979-74145158 (+)
PWK/PhJ MGP_PWKPhJ_G0024785
 protein coding gene Chr2:71610408-71613651 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024593
 protein coding gene Chr2:74375793-74378952 (+)
WSB/EiJ MGP_WSBEiJ_G0025112
 protein coding gene Chr2:74577948-74581101 (+)



Homology
more
  • Human Ortholog
    HOXD10, homeobox D10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXD10, homeobox D10
  • Synonyms
    HOX4, Hox-4.4, HOX4D, HOX4E
  • Links
    NCBI Gene ID: 3236
    neXtProt AC: NX_P28358
    UniProt: P28358

  • Chr Location
    2q31.1; chr2:176108790-176119937 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HOXD10 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    37 phenotypes from multigenic genotypes
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit an abnormal gait associated with defects in sacral vertebrae (including homeotic transformations), hindlimb bones, and muscle innervation. These defects are sometimes seen in heterozygotes as well.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1198
  • Tissues
    247
  • cDNA Data
    19
  • Literature Summary
    120
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050368 Ensembl Gene Model | MGI Sequence Detail 3182 C57BL/6J ±  kb
    transcript ENSMUST00000061745 Ensembl | MGI Sequence Detail 1816 Not Applicable  
    polypeptide ENSMUSP00000062412 Ensembl | MGI Sequence Detail 340 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 12
      cDNA 23
      Primer pair 9
      Other 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10852, MGD-MRK-10860, MGD-MRK-10903, MGI:2138919, MGI:2139108
    References
    more
    • Summaries
      All 203
      Developmental Gene Expression 120
      Gene Ontology 13
      Phenotypes 76
    • Earliest
      J:9951 Duboule D, et al., The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes. EMBO J. 1989 May;8(5):1497-505
    • Latest
      J:342014 Chen Y, et al., Hnrnpk is essential for embryonic limb bud development as a transcription activator and a collaborator of insulator protein Ctcf. Cell Death Differ. 2023 Oct;30(10):2293-2308
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory