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Lipc Gene Detail
Summary
  • Symbol
    Lipc
  • Name
    lipase, hepatic
  • Synonyms
    HL, Hpl
  • Feature Type
    protein coding gene
  • IDs
    MGI:96216
    NCBI Gene: 15450
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:70705410-70859503 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 39.57 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4271 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96216
 protein coding gene Chr9:70705410-70859508 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035005
 protein coding gene Chr9:70913093-71053163 (-)
A/J MGP_AJ_G0034986
 protein coding gene Chr9:68432506-68567284 (-)
AKR/J MGP_AKRJ_G0034915
 protein coding gene Chr9:70049941-70194631 (-)
BALB/cJ MGP_BALBcJ_G0034978
 protein coding gene Chr9:68148577-68285315 (-)
C3H/HeJ MGP_C3HHeJ_G0034687
 protein coding gene Chr9:70581138-70716688 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035497
 protein coding gene Chr9:72796242-72936638 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032408
 protein coding gene Chr9:67976321-68104543 (-)
CAST/EiJ MGP_CASTEiJ_G0034009
 protein coding gene Chr9:70850708-70993394 (-)
CBA/J MGP_CBAJ_G0034660
 protein coding gene Chr9:75316038-75461943 (-)
DBA/2J MGP_DBA2J_G0034819
 protein coding gene Chr9:68172340-68305293 (-)
FVB/NJ MGP_FVBNJ_G0034761
 protein coding gene Chr9:67494644-67626221 (-)
LP/J MGP_LPJ_G0034900
 protein coding gene Chr9:71142781-71278473 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034802
 protein coding gene Chr9:76382426-76523308 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035519
 protein coding gene Chr9:70206564-70342668 (-)
PWK/PhJ MGP_PWKPhJ_G0033713
 protein coding gene Chr9:68421715-68555880 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033546
 protein coding gene Chr9:70506176-70640413 (-)
WSB/EiJ MGP_WSBEiJ_G0034121
 protein coding gene Chr9:70108301-70246205 (-)



Homology
more
  • Human Ortholog
    LIPC, lipase C, hepatic type
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIPC, lipase C, hepatic type
  • Synonyms
    HDLCQ12, HL, HTGL, LIPH
  • Links
    NCBI Gene ID: 3990
    neXtProt AC: NX_P11150
    UniProt: P11150

  • Chr Location
    15q21.3; chr15:58410569-58569844 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human LIPC associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit elevated plasma total cholesterol, phospholipids, and high density lipoprotein cholesterol.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    10
  • cDNA Data
    31
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15450 NCBI Gene Model | MGI Sequence Detail 154094 C57BL/6J ±  kb
    transcript NM_008280 RefSeq | MGI Sequence Detail 1934 FVB/N  
    polypeptide P27656 UniProt | EBI | MGI Sequence Detail 510 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 1
      cDNA 33
      Primer pair 2
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10920, MGI:2142998
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 7
      Gene Ontology 12
      Phenotypes 42
    • Earliest
      J:20061 Blomberg B, et al., DNA sequences of the joining regions of mouse lambda light chain immunoglobulin genes. Proc Natl Acad Sci U S A. 1982 Jan;79(2):530-3
    • Latest
      J:338938 Kobayashi K, et al., Feto-maternal cholesterol transport regulated by beta-Klotho-FGF15 axis is essential for fetal growth. Life Sci Alliance. 2023 Oct;6(10)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory