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Htr2c Gene Detail
Summary
  • Symbol
    Htr2c
  • Name
    5-hydroxytryptamine (serotonin) receptor 2C
  • Synonyms
    5HT1c, 5-HT2cR, 5-HT2C receptor, Htr1c, SR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96281
    NCBI Gene: 15560
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:145745509-145980273 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 68.46 cM, cytoband D-F4
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5441 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96281
 protein coding gene ChrX:145745509-145980273 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036163
 protein coding gene ChrX:144566593-144815594 (+)
A/J MGP_AJ_G0036140
 protein coding gene ChrX:143844887-144076317 (+)
AKR/J MGP_AKRJ_G0036066
 protein coding gene ChrX:148572284-148824446 (+)
BALB/cJ MGP_BALBcJ_G0036131
 protein coding gene ChrX:142068442-142302378 (+)
C3H/HeJ MGP_C3HHeJ_G0035839
 protein coding gene ChrX:144673378-144924606 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036655
 protein coding gene ChrX:148659156-148909288 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033480
 protein coding gene ChrX:135328493-135540680 (+)
CAST/EiJ MGP_CASTEiJ_G0035130
 protein coding gene ChrX:125211317-125464424 (+)
CBA/J MGP_CBAJ_G0035816
 protein coding gene ChrX:153255781-153524819 (+)
DBA/2J MGP_DBA2J_G0035974
 protein coding gene ChrX:142883398-143130886 (+)
FVB/NJ MGP_FVBNJ_G0035908
 protein coding gene ChrX:142109427-142349966 (+)
LP/J MGP_LPJ_G0036065
 protein coding gene ChrX:145466450-145702716 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035944
 protein coding gene ChrX:161304987-161614614 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036691
 protein coding gene ChrX:143840835-144081761 (+)
PWK/PhJ MGP_PWKPhJ_G0034824
 protein coding gene ChrX:121926077-122175344 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034650
 protein coding gene ChrX:125772134-126031668 (+)
WSB/EiJ MGP_WSBEiJ_G0035265
 protein coding gene ChrX:142149002-142390735 (+)



Homology
more
  • Human Ortholog
    HTR2C, 5-hydroxytryptamine receptor 2C
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTR2C, 5-hydroxytryptamine receptor 2C
  • Synonyms
    5-HT1C, 5-HT2C, 5-HTR2C, 5HTR2C, HTR1C
  • Links
    NCBI Gene ID: 3358
    neXtProt AC: NX_P28335
    UniProt: P28335

  • Chr Location
    Xq23; chrX:114584078-114910061 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Htr2c mouse models; 3 with human HTR2C associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    77 phenotypes from 8 alleles in 13 genetic backgrounds
    4 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit hyperactivity, hyperphagia, reduced energy cost of locomotion, late-onset obesity, insulin resistance, and altered responses to cocaine. Mutants are also subject to spontaneous death from seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    870
  • Tissues
    99
  • cDNA Data
    8
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15560 NCBI Gene Model | MGI Sequence Detail 234765 C57BL/6J ±  kb
    transcript NM_008312 RefSeq | MGI Sequence Detail 4765 ZRU/MplStud  
    polypeptide P34968 UniProt | EBI | MGI Sequence Detail 459 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 3
      cDNA 11
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11001, MGD-MRK-11008, MGI:96275
    References
    more
    • Summaries
      All 153
      Developmental Gene Expression 13
      Diseases 2
      Gene Ontology 16
      Phenotypes 71
    • Earliest
      J:40017 Lubbert H, et al., cDNA cloning of a serotonin 5-HT1C receptor by electrophysiological assays of mRNA-injected Xenopus oocytes. Proc Natl Acad Sci U S A. 1987 Jun;84(12):4332-6
    • Latest
      J:352453 Flanigan ME, et al., Subcortical serotonin 5HT(2c) receptor-containing neurons sex-specifically regulate binge-like alcohol consumption, social, and arousal behaviors in mice. Nat Commun. 2023 Mar 31;14(1):1800
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory