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Id2 Gene Detail
Summary
  • Symbol
    Id2
  • Name
    inhibitor of DNA binding 2
  • Synonyms
    bHLHb26, C78922, Idb2, inhibitor of differentiation 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96397
    NCBI Gene: 15902
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:25143798-25146091 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 8.57 cM, cytoband B
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96397
 protein coding gene Chr12:25143798-25147139 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019635
 protein coding gene Chr12:22795261-22797554 (-)
A/J MGP_AJ_G0019602
 protein coding gene Chr12:22168238-22170531 (-)
AKR/J MGP_AKRJ_G0019573
 protein coding gene Chr12:22915740-22918032 (-)
BALB/cJ MGP_BALBcJ_G0019579
 protein coding gene Chr12:22437751-22440044 (-)
C3H/HeJ MGP_C3HHeJ_G0019383
 protein coding gene Chr12:22803661-22805953 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020027
 protein coding gene Chr12:23515591-23517882 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017651
 protein coding gene Chr12:21646699-21648974 (-)
CAST/EiJ MGP_CASTEiJ_G0018938
 protein coding gene Chr12:17779728-17781959 (-)
CBA/J MGP_CBAJ_G0019354
 protein coding gene Chr12:24249193-24251485 (-)
DBA/2J MGP_DBA2J_G0019468
 protein coding gene Chr12:22020405-22022697 (-)
FVB/NJ MGP_FVBNJ_G0019459
 protein coding gene Chr12:21911784-21914077 (-)
LP/J MGP_LPJ_G0019538
 protein coding gene Chr12:22877682-22879974 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019494
 protein coding gene Chr12:24108533-24110826 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020066
 protein coding gene Chr12:22485389-22487681 (-)
PWK/PhJ MGP_PWKPhJ_G0018705
 protein coding gene Chr12:16764067-16766300 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018493
 protein coding gene Chr12:16995617-16997855 (-)
WSB/EiJ MGP_WSBEiJ_G0018989
 protein coding gene Chr12:22634320-22636617 (-)



Homology
more
  • Human Ortholog
    ID2, inhibitor of DNA binding 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ID2, inhibitor of DNA binding 2
  • Synonyms
    bHLHb26, GIG8, ID2A, ID2H
  • Links
    NCBI Gene ID: 3398
    neXtProt AC: NX_Q02363
    UniProt: Q02363

  • Chr Location
    2p25.1; chr2:8678845-8684461 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 7 alleles in 10 genetic backgrounds
    27 phenotypes from multigenic genotypes
    186 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display postnatal lethality with immune system defects. Homozygotes may also have defects in the digestive tract, kidneys, adipose tissue and in mammary gland development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    103
  • GO References
    40
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1499
  • Tissues
    494
  • cDNA Data
    213
  • Literature Summary
    202
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15902 NCBI Gene Model | MGI Sequence Detail 2294 C57BL/6J ±  kb
    transcript NM_010496 RefSeq | MGI Sequence Detail 1289 ZRU/MplStud  
    polypeptide P41136 UniProt | EBI | MGI Sequence Detail 134 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 248
      Genomic 3
      cDNA 218
      Primer pair 13
      Other 14

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11154, MGI:2144775, MGI:2145094
    References
    more
    • Summaries
      All 465
      Developmental Gene Expression 202
      Gene Ontology 40
      Phenotypes 186
    • Earliest
      J:18120 Sun XH, et al., Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol. 1991 Nov;11(11):5603-11
    • Latest
      J:349808 Sun J, et al., Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance. Immunity. 2024 Jun 11;57(6):1289-1305.e9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory