| Human Disease | Mouse Models | ||||
|---|---|---|---|---|---|
|
IDs
|
||||
|
IDs
|
|||||
|
IDs
|
|||||
|
IDs
|
|||||
|
IDs
|
|||||
|
IDs
|
|||||
|
IDs
|
|||||
|
IDs
|
|||||
|
IDs
|
|||||
|
IDs
|
|||||
|
IDs
|
|||||
|
IDs
|
early conceptus |
embryo ectoderm |
embryo endoderm |
embryo mesoderm |
embryo mesenchyme |
extraembryonic component |
alimentary system |
auditory system |
branchial arches |
cardiovascular system |
connective tissue |
endocrine system |
exocrine system |
hemolymphoid system |
integumental system |
limbs |
liver and biliary system |
musculoskeletal system |
nervous system |
olfactory system |
reproductive system |
respiratory system |
urinary system |
visual system |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Transcription Start Site | Location | Distance from Gene 5'-end |
| Tssr95035 | Chr10:87694117-87694156 (+) | 10 bp |
| Tssr95036 | Chr10:87694464-87694482 (+) | 346 bp |
| Tssr95037 | Chr10:87694501-87694511 (+) | 379 bp |
| Tssr95038 | Chr10:87694518-87694527 (+) | 396 bp |
| Tssr95039 | Chr10:87694543-87694557 (+) | 423 bp |
| Tssr95040 | Chr10:87694678-87694694 (+) | 559 bp |
| Tssr95041 | Chr10:87694908-87694919 (+) | 787 bp |
| Tssr95042 | Chr10:87694924-87694956 (+) | 813 bp |
| Tssr95043 | Chr10:87694969-87694988 (+) | 852 bp |
| Tssr95044 | Chr10:87695020-87695040 (+) | 903 bp |
| Tssr95045 | Chr10:87695042-87695057 (+) | 923 bp |
| Tssr95046 | Chr10:87695061-87695078 (+) | 943 bp |
| Tssr95047 | Chr10:87695095-87695106 (+) | 974 bp |
| Tssr95048 | Chr10:87695117-87695128 (+) | 996 bp |
| Tssr95049 | Chr10:87695141-87695150 (+) | 1,019 bp |
| Tssr95050 | Chr10:87695153-87695164 (+) | 1,032 bp |
| Tssr95051 | Chr10:87695172-87695196 (+) | 1,057 bp |
| Tssr95052 | Chr10:87695197-87695198 (+) | 1,071 bp |
| Tssr95053 | Chr10:87695218-87695229 (+) | 1,097 bp |
| Tssr95054 | Chr10:87695234-87695249 (+) | 1,115 bp |
| Tssr95055 | Chr10:87695343-87695354 (+) | 1,222 bp |
| Tssr95056 | Chr10:87695397-87695434 (+) | 1,289 bp |
| Tssr95057 | Chr10:87695455-87695474 (+) | 1,338 bp |
| Tssr95058 | Chr10:87695498-87695509 (+) | 1,377 bp |
| Tssr95059 | Chr10:87695560-87695569 (+) | 1,438 bp |
| Tssr95060 | Chr10:87695924-87695948 (+) | 1,809 bp |
| Tssr95061 | Chr10:87696006-87696021 (+) | 1,887 bp |
| Tssr95062 | Chr10:87696028-87696041 (+) | 1,908 bp |
| Tssr95063 | Chr10:87696083-87696102 (+) | 1,966 bp |
| Tssr95064 | Chr10:87696111-87696129 (+) | 1,993 bp |
| Tssr95065 | Chr10:87696299-87696326 (+) | 2,186 bp |
| Tssr95066 | Chr10:87696339-87696354 (+) | 2,220 bp |
| Tssr95067 | Chr10:87696686-87696692 (+) | 2,562 bp |
| Tssr95068 | Chr10:87696868-87696893 (+) | 2,754 bp |
| Tssr95069 | Chr10:87696939-87696971 (+) | 2,828 bp |
| Tssr95070 | Chr10:87697157-87697168 (+) | 3,036 bp |
| Tssr95071 | Chr10:87697171-87697200 (+) | 3,059 bp |
| Tssr95072 | Chr10:87699646-87699660 (+) | 5,526 bp |
| Tssr95073 | Chr10:87699890-87699931 (+) | 5,784 bp |
| Tssr95074 | Chr10:87700191-87700231 (+) | 6,084 bp |
| Tssr95075 | Chr10:87700584-87700723 (+) | 6,527 bp |
| Tssr95076 | Chr10:87700733-87700764 (+) | 6,622 bp |
| Tssr95077 | Chr10:87700882-87700899 (+) | 6,764 bp |
| Tssr95078 | Chr10:87707798-87707811 (+) | 13,678 bp |
| Tssr95079 | Chr10:87716676-87716687 (+) | 22,555 bp |
| Tssr95080 | Chr10:87716805-87716818 (+) | 22,685 bp |
| Tssr95081 | Chr10:87728276-87728278 (+) | 34,150 bp |
| Tssr95082 | Chr10:87728327-87728349 (+) | 34,211 bp |
| Tssr95083 | Chr10:87728356-87728375 (+) | 34,239 bp |
| Tssr95084 | Chr10:87728447-87728476 (+) | 34,335 bp |
| Tssr95085 | Chr10:87739828-87739853 (+) | 45,714 bp |
| Tssr95086 | Chr10:87742783-87742797 (+) | 48,663 bp |
| Tssr95087 | Chr10:87743827-87743839 (+) | 49,706 bp |
| Tssr95088 | Chr10:87749467-87749484 (+) | 55,349 bp |
| Tssr95089 | Chr10:87749488-87749501 (+) | 55,368 bp |
| Tssr95090 | Chr10:87749510-87749524 (+) | 55,390 bp |
| Tssr95091 | Chr10:87749526-87749546 (+) | 55,409 bp |
| Tssr95092 | Chr10:87749553-87749564 (+) | 55,432 bp |
| Tssr95093 | Chr10:87749566-87749598 (+) | 55,455 bp |
| Tssr95094 | Chr10:87749609-87749623 (+) | 55,489 bp |
| Tssr95095 | Chr10:87749628-87749631 (+) | 55,503 bp |
| Tssr95096 | Chr10:87750238-87750249 (+) | 56,117 bp |
| Tssr95097 | Chr10:87750254-87750275 (+) | 56,138 bp |
| Tssr95098 | Chr10:87750386-87750401 (+) | 56,267 bp |
| Tssr95099 | Chr10:87751149-87751175 (+) | 57,035 bp |
| Tssr95100 | Chr10:87752163-87752170 (+) | 58,040 bp |
| Tssr95101 | Chr10:87752220-87752238 (+) | 58,102 bp |
| Tssr95102 | Chr10:87752254-87752281 (+) | 58,141 bp |
| Tssr95103 | Chr10:87752289-87752300 (+) | 58,168 bp |
| Tssr95104 | Chr10:87752338-87752369 (+) | 58,227 bp |
| Tssr95105 | Chr10:87757457-87757461 (+) | 63,332 bp |
| Tssr95106 | Chr10:87759089-87759129 (+) | 64,982 bp |
| Tssr95107 | Chr10:87761124-87761128 (+) | 66,999 bp |
| Tssr95108 | Chr10:87762258-87762267 (+) | 68,136 bp |
| Tssr95109 | Chr10:87764957-87765007 (+) | 70,855 bp |
| Tssr95110 | Chr10:87765104-87765118 (+) | 70,984 bp |
| Tssr95111 | Chr10:87766549-87766559 (+) | 72,427 bp |
| Tssr95112 | Chr10:87766591-87766670 (+) | 72,504 bp |
| Tssr95113 | Chr10:87766717-87766734 (+) | 72,599 bp |
| Tssr95114 | Chr10:87766814-87766827 (+) | 72,694 bp |
| Tssr95115 | Chr10:87767002-87767031 (+) | 72,890 bp |
| Tssr95116 | Chr10:87767163-87767193 (+) | 73,051 bp |
| Tssr95117 | Chr10:87767204-87767216 (+) | 73,083 bp |
| Tssr95118 | Chr10:87767315-87767326 (+) | 73,194 bp |
| Tssr95119 | Chr10:87767340-87767351 (+) | 73,219 bp |
| Tssr95120 | Chr10:87767436-87767447 (+) | 73,315 bp |
| Tssr95121 | Chr10:87767934-87767946 (+) | 73,813 bp |
| Tssr95122 | Chr10:87768288-87768303 (+) | 74,169 bp |
| Tssr95123 | Chr10:87768638-87768650 (+) | 74,517 bp |
| Tssr95124 | Chr10:87768663-87768681 (+) | 74,545 bp |
| Tssr95125 | Chr10:87769059-87769071 (+) | 74,938 bp |
| Tssr95126 | Chr10:87769097-87769158 (+) | 75,001 bp |
| Tssr95127 | Chr10:87769194-87769233 (+) | 75,087 bp |
| Tssr95128 | Chr10:87769236-87769255 (+) | 75,119 bp |
| Tssr95129 | Chr10:87769571-87769587 (+) | 75,452 bp |
| Tssr95130 | Chr10:87769699-87769710 (+) | 75,578 bp |
| Tssr95131 | Chr10:87769869-87769907 (+) | 75,761 bp |
| Tssr95132 | Chr10:87770531-87770548 (+) | 76,413 bp |
| Tssr95133 | Chr10:87770682-87770712 (+) | 76,570 bp |
| Tssr95134 | Chr10:87771070-87771079 (+) | 76,948 bp |
| Tssr95135 | Chr10:87771769-87771792 (+) | 77,654 bp |
| Tssr95136 | Chr10:87771815-87771856 (+) | 77,709 bp |
| Tssr95137 | Chr10:87771951-87771962 (+) | 77,830 bp |
| QTL | Genetic Location* | Genome Location (GRCm39) | Reference | QTL Note |
| Bgeq8 | Chr10, 66.75 cM | J:99477 | Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified. | |
| Igfbp3q2 | Chr10, syntenic | J:99477 | Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified. | |
| Insq9 | Chr10, 39.72 cM | Chr10:82490938-82491121 | J:99477 | Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified. |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|
|
||
Analysis Tools
