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Igfbp4 Gene Detail
Summary
  • Symbol
    Igfbp4
  • Name
    insulin-like growth factor binding protein 4
  • Synonyms
    Band 3A, Deb2, IGFBP-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96439
    NCBI Gene: 16010
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98930820-98943481 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 62.92 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    403 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96439
 protein coding gene Chr11:98930820-98945218 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019081
 protein coding gene Chr11:101674985-101691666 (+)
A/J MGP_AJ_G0019049
 protein coding gene Chr11:97405171-97418632 (+)
AKR/J MGP_AKRJ_G0019019
 protein coding gene Chr11:100423272-100436949 (+)
BALB/cJ MGP_BALBcJ_G0019023
 protein coding gene Chr11:97897807-97911223 (+)
C3H/HeJ MGP_C3HHeJ_G0018836
 protein coding gene Chr11:100569421-100584276 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019474
 protein coding gene Chr11:104812099-104826250 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017106
 protein coding gene Chr11:94962753-94975918 (+)
CAST/EiJ MGP_CASTEiJ_G0018390
 protein coding gene Chr11:101557717-101575327 (+)
CBA/J MGP_CBAJ_G0018807
 protein coding gene Chr11:109159968-109175165 (+)
DBA/2J MGP_DBA2J_G0018915
 protein coding gene Chr11:96964781-96978401 (+)
FVB/NJ MGP_FVBNJ_G0018904
 protein coding gene Chr11:96481746-96496700 (+)
LP/J MGP_LPJ_G0018985
 protein coding gene Chr11:102139219-102152205 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018931
 protein coding gene Chr11:108840193-108855875 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019514
 protein coding gene Chr11:100783650-100797992 (+)
PWK/PhJ MGP_PWKPhJ_G0018161
 protein coding gene Chr11:98021265-98039049 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017950
 protein coding gene Chr11:100532763-100544750 (+)
WSB/EiJ MGP_WSBEiJ_G0018439
 protein coding gene Chr11:100746470-100760727 (+)



Homology
more
  • Human Ortholog
    IGFBP4, insulin like growth factor binding protein 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGFBP4, insulin like growth factor binding protein 4
  • Synonyms
    BP-4, HT29-IGFBP, IBP4, IGFBP-4
  • Links
    NCBI Gene ID: 3487
    neXtProt AC: NX_P22692
    UniProt: P22692

  • Chr Location
    17q21.2; chr17:40443450-40457725 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a similar reduction in birth and postnatal body weight, and show impaired glucose homeostasis relative to wild-type controls.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    69
  • cDNA Data
    480
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16010 NCBI Gene Model | MGI Sequence Detail 12662 C57BL/6J ±  kb
    transcript NM_010517 RefSeq | MGI Sequence Detail 2108 C57BL/6  
    polypeptide P47879 UniProt | EBI | MGI Sequence Detail 254 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000008950 insulin-like growth factor-binding protein 4
      (term hierarchy)
    • InterPro Domains
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR022327 Insulin-like growth factor-binding protein 4
      IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
      IPR000867 Insulin-like growth factor-binding protein, IGFBP
      IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
      IPR000716 Thyroglobulin type-1
      IPR036857 Thyroglobulin type-1 superfamily
    • GlyGen
      P47879 1 site
    Molecular
    Reagents
    less
    • All nucleic 490
      Genomic 1
      cDNA 481
      Primer pair 6
      Other 2

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-11236, MGI:1349476, MGI:2144326
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 44
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:3735 Donahue LR, et al., Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J Endocrinol. 1993 Jan;136(1):91-104
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory