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Ighm Gene Detail
Summary
  • Symbol
    Ighm
  • Name
    immunoglobulin heavy constant mu
  • Synonyms
    BCR, Igh6, Igh-M, IgM, Ig mu, muH, muMT
  • Feature Type
    gene segment
  • IDs
    MGI:96448
    NCBI Gene: 16019
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:113382446-113386350 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 62.10 cM, cytoband F1-2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96448
 gene segment Chr12:113382178-113386350 (-)
129S1/SvImJ MGP_129S1SvImJ_G0000010
 gene segment Chr12:115977153-115981330 (-)
A/J MGP_AJ_G0000010
 gene segment Chr12:111456086-111460236 (-)
AKR/J MGP_AKRJ_G0000009
 gene segment Chr12:114720694-114728789 (-)
BALB/cJ MGP_BALBcJ_G0000010
 gene segment Chr12:111916877-111921040 (-)
C3H/HeJ MGP_C3HHeJ_G0000010
 gene segment Chr12:115205487-115209647 (-)
C57BL/6NJ MGP_C57BL6NJ_G0000010
 gene segment Chr12:119469403-119473561 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0000009
 gene segment Chr12:107856764-107860905 (-)
CAST/EiJ MGP_CASTEiJ_G0000011
 gene segment Chr12:110093908-110099539 (-)
CBA/J MGP_CBAJ_G0000010
 gene segment Chr12:124089146-124093310 (-)
DBA/2J MGP_DBA2J_G0000010
 gene segment Chr12:110955153-110959325 (-)
FVB/NJ MGP_FVBNJ_G0000010
 gene segment Chr12:109795428-109799588 (-)
LP/J MGP_LPJ_G0000010
 gene segment Chr12:115775225-115779383 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0000009
 gene segment Chr12:127179047-127183221 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0000010
 gene segment Chr12:114211344-114215515 (-)
PWK/PhJ MGP_PWKPhJ_G0000010
 gene segment Chr12:105645849-105650558 (-)
SPRET/EiJ MGP_SPRETEiJ_G0000009
 gene segment Chr12:108389542-108393694 (-)
WSB/EiJ MGP_WSBEiJ_G0000010
 gene segment Chr12:115149534-115153746 (-)



Homology
more
  • Human Ortholog
    IGHM, immunoglobulin heavy constant mu
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGHM, immunoglobulin heavy constant mu
  • Synonyms
    AGM1, MU, VH
  • Links
    NCBI Gene ID: 3507
    UniProt: P01871

  • Chr Location
    14q32.33; chr14:105851705-105856218 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ighm mouse models; 1 with human IGHM associations

Human Disease Mouse Models
      
IDs
 View 5 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    98 phenotypes from 13 alleles in 19 genetic backgrounds
    65 phenotypes from multigenic genotypes
    1018 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal immune system morphology and physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    41
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    20
  • cDNA Data
    16
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      108
    • RefSeq
      1
    • UniProt
      12
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16019 NCBI Gene Model | MGI Sequence Detail 3905 C57BL/6J ±  kb
    transcript BC053409 GenBank | ENA | DDBJ | MGI Sequence Detail 2172 C57BL/6NCr  
    polypeptide P01872 UniProt | EBI | MGI Sequence Detail 454 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 107
      Genomic 36
      cDNA 65
      Primer pair 4
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11245, MGD-MRK-11260, MGI:2144796
    References
    more
    • Summaries
      All 1164
      Developmental Gene Expression 7
      Diseases 6
      Gene Ontology 41
      Phenotypes 1018
    • Earliest
      J:5763 Warner NL, et al., Allotypes of mouse IgM immunoglobulin. Nature. 1977 Feb 3;265(5593):447-9
    • Latest
      J:357414 Porier DL, et al., Humoral and T-cell-mediated responses to an insect-specific flavivirus-based Zika virus vaccine candidate. PLoS Pathog. 2024 Oct;20(10):e1012566
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory