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Cd74 Gene Detail
Summary
  • Symbol
    Cd74
  • Name
    CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
  • Synonyms
    CLIP, Ii
  • Feature Type
    protein coding gene
  • IDs
    MGI:96534
    NCBI Gene: 16149
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:60936921-60945724 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 34.41 cM
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    396 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96534
 protein coding gene Chr18:60936920-60945724 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024468
 protein coding gene Chr18:60610813-60647795 (+)
A/J MGP_AJ_G0024435
 protein coding gene Chr18:58040833-58050323 (+)
AKR/J MGP_AKRJ_G0024405
 protein coding gene Chr18:59625661-59646379 (+)
BALB/cJ MGP_BALBcJ_G0024435
 protein coding gene Chr18:58178513-58187977 (+)
C3H/HeJ MGP_C3HHeJ_G0024202
 protein coding gene Chr18:59861587-59881356 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024881
 protein coding gene Chr18:62262211-62303090 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022312
 protein coding gene Chr18:57583814-57595939 (+)
CAST/EiJ MGP_CASTEiJ_G0023675
 protein coding gene Chr18:59739232-59748052 (+)
CBA/J MGP_CBAJ_G0024172
 protein coding gene Chr18:64303104-64312567 (+)
DBA/2J MGP_DBA2J_G0024302
 protein coding gene Chr18:57705619-57725137 (+)
FVB/NJ MGP_FVBNJ_G0024268
 protein coding gene Chr18:57116954-57131160 (+)
LP/J MGP_LPJ_G0024385
 protein coding gene Chr18:60482313-60501131 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024297
 protein coding gene Chr18:65939636-65950021 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024928
 protein coding gene Chr18:59834601-59847385 (+)
PWK/PhJ MGP_PWKPhJ_G0023418
 protein coding gene Chr18:57939666-57950098 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023224
 protein coding gene Chr18:60075289-60083592 (+)
WSB/EiJ MGP_WSBEiJ_G0023739
 protein coding gene Chr18:59662532-59701276 (+)



Homology
more
  • Human Ortholog
    CD74, CD74 molecule
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD74, CD74 molecule
  • Synonyms
    CLIP, DHLAG, HLADG, Ia-GAMMA, II, p33
  • Links
    NCBI Gene ID: 972
    neXtProt AC: NX_P04233
    UniProt: P04233

  • Chr Location
    5q33.1; chr5:150401637-150412969 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 6 alleles in 14 genetic backgrounds
    42 phenotypes from multigenic genotypes
    1 images
    138 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired transport of MHC class II molecules, poor antigen presentation, and deficiency of CD4+ T cell development and positive selection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    135
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    4
  • cDNA Data
    318
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16149 NCBI Gene Model | MGI Sequence Detail 8804 C57BL/6J ±  kb
    transcript NM_001042605 RefSeq | MGI Sequence Detail 1431 ZRU/MplStud  
    polypeptide P04441 UniProt | EBI | MGI Sequence Detail 279 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000001822 MHC class II histocompatibility antigen gamma chain
      (term hierarchy)
    • InterPro Domains
      IPR043530 HLA class II histocompatibility antigen, gamma subunit
      IPR022339 MHC class II-associated invariant chain
      IPR015386 MHC class II-associated invariant chain/CLIP, MHC II-interacting
      IPR011988 MHC class II-associated invariant chain, trimerisation
      IPR036613 MHC class II-associated invariant chain, trimerisation domain superfamily
      IPR052001 MHC Class II Gamma Chain/Thyroglobulin
      IPR000716 Thyroglobulin type-1
      IPR036857 Thyroglobulin type-1 superfamily
    • GlyGen
      P04441 4 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 324
      Genomic 3
      cDNA 319
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11344
    References
    more
    • Summaries
      All 233
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 28
      Phenotypes 138
    • Earliest
      J:6994 Day CE, et al., The gene encoding the Ia antigen-associated invariant chain (Ii) is not linked to the H-2 complex. Nature. 1983 Mar 10;302(5904):157-9
    • Latest
      J:349865 Carabana C, et al., Spatially distinct epithelial and mesenchymal cell subsets along progressive lineage restriction in the branching embryonic mammary gland. EMBO J. 2024 Jun;43(12):2308-2336
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory