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Il10 Gene Detail
Summary
  • Symbol
    Il10
  • Name
    interleukin 10
  • Synonyms
    cytokine synthesis inhibitory factor, IL-10
  • Feature Type
    protein coding gene
  • IDs
    MGI:96537
    NCBI Gene: 16153
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:130947582-130952711 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 56.89 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    224 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96537
 protein coding gene Chr1:130947459-130952711 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016447
 protein coding gene Chr1:134426827-134431958 (+)
A/J MGP_AJ_G0016430
 protein coding gene Chr1:129458891-129464020 (+)
AKR/J MGP_AKRJ_G0016395
 protein coding gene Chr1:133272306-133279361 (+)
BALB/cJ MGP_BALBcJ_G0016390
 protein coding gene Chr1:129789839-129794959 (+)
C3H/HeJ MGP_C3HHeJ_G0016216
 protein coding gene Chr1:133406801-133411929 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016851
 protein coding gene Chr1:139427000-139433080 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014565
 protein coding gene Chr1:122591288-122595811 (+)
CAST/EiJ MGP_CASTEiJ_G0015796
 protein coding gene Chr1:132402598-132407749 (+)
CBA/J MGP_CBAJ_G0016188
 protein coding gene Chr1:144228494-144233627 (+)
DBA/2J MGP_DBA2J_G0016295
 protein coding gene Chr1:128424919-128430401 (+)
FVB/NJ MGP_FVBNJ_G0016294
 protein coding gene Chr1:127055631-127060867 (+)
LP/J MGP_LPJ_G0016366
 protein coding gene Chr1:135739424-135744551 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016319
 protein coding gene Chr1:149998548-150003675 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016887
 protein coding gene Chr1:133031779-133038041 (+)
PWK/PhJ MGP_PWKPhJ_G0015582
 protein coding gene Chr1:127384893-127390264 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015369
 protein coding gene Chr1:131963602-131968770 (+)
WSB/EiJ MGP_WSBEiJ_G0015858
 protein coding gene Chr1:133016711-133023996 (+)



Homology
more
  • Human Ortholog
    IL10, interleukin 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL10, interleukin 10
  • Synonyms
    CSIF, GVHDS, IL-10, IL10A, TGIF
  • Links
    NCBI Gene ID: 3586
    neXtProt AC: NX_P22301
    UniProt: P22301

  • Chr Location
    1q32.1; chr1:206767602-206774541 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Il10 mouse models; 53 with human IL10 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    152 phenotypes from 11 alleles in 16 genetic backgrounds
    63 phenotypes from multigenic genotypes
    2 images
    1230 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit retarded growth, anemia, chronic enterocolitis, a high incidence of colorectal adenocarcinomas, and altered responses to various infectious organisms such as Mycobacterium bovis and Leishmania donovani.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    87
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    8
  • cDNA Data
    9
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016529 Ensembl Gene Model | MGI Sequence Detail 5130 C57BL/6J ±  kb
    transcript ENSMUST00000016673 Ensembl | MGI Sequence Detail 1310 Not Applicable  
    polypeptide ENSMUSP00000016673 Ensembl | MGI Sequence Detail 178 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 9
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11347, MGD-MRK-11361
    References
    more
    • Summaries
      All 1767
      Developmental Gene Expression 23
      Diseases 6
      Gene Ontology 25
      Phenotypes 1230
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:355703 Zhang Z, et al., Arjunolic acid protects the intestinal epithelial barrier, ameliorating Crohn's disease-like colitis by restoring gut microbiota composition and inactivating TLR4 signalling. Phytomedicine. 2024 Jan;123:155223
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory