Il12a MGI Mouse Gene Detail - MGI:96539

Symbol

Il12a
Name

interleukin 12a
Synonyms

IL-12p35, p35

Feature Type

protein coding gene
IDs

MGI:96539
NCBI Gene: 16159
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr3:68597977-68605880 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 31.92 cM
Mapping Data

8 experiments

SNPs within 2kb

389 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96539	protein coding gene	Chr3:68597977-68605881 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027287	protein coding gene	Chr3:67913814-67921717 (+)
A/J	MGP_AJ_G0027249	protein coding gene	Chr3:65899113-65907016 (+)
AKR/J	MGP_AKRJ_G0027217	protein coding gene	Chr3:67302094-67309997 (+)
BALB/cJ	MGP_BALBcJ_G0027260	protein coding gene	Chr3:65775849-65783752 (+)
C3H/HeJ	MGP_C3HHeJ_G0027004	protein coding gene	Chr3:67568478-67576381 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027706	protein coding gene	Chr3:70440507-70448410 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025059	protein coding gene	Chr3:62178165-62186100 (+)
CAST/EiJ	MGP_CASTEiJ_G0026451	protein coding gene	Chr3:67503424-67511295 (+)
CBA/J	MGP_CBAJ_G0026979	protein coding gene	Chr3:72637426-72645329 (+)
DBA/2J	MGP_DBA2J_G0027115	protein coding gene	Chr3:65401216-65409119 (+)
FVB/NJ	MGP_FVBNJ_G0027083	protein coding gene	Chr3:64018571-64026474 (+)
LP/J	MGP_LPJ_G0027223	protein coding gene	Chr3:68845093-68852996 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027102	protein coding gene	Chr3:77253121-77261024 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027764	protein coding gene	Chr3:67179822-67187725 (+)
PWK/PhJ	MGP_PWKPhJ_G0026185	protein coding gene	Chr3:65133509-65141440 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026001	protein coding gene	Chr3:66305649-66313579 (+)
WSB/EiJ	MGP_WSBEiJ_G0026529	protein coding gene	Chr3:67316361-67324264 (+)

Human Ortholog

IL12A, interleukin 12A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL12A, interleukin 12A
Synonyms

CLMF, IL-12A, NFSK, NKSF1, P35
Links

HGNC:5969

NCBI Gene ID: 3592

neXtProt AC: NX_P29459

UniProt: P29459
Chr Location

3q25.33; chr3:159988835-159996019 (+) GRCh38

MGI Vertebrate Homology

Il12a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: IL12A
Gene Tree

Il12a

Diseases

3 with human IL12A associations

				Human Disease	Mouse Models
				hepatitis C IDs hepatitis C DOID:1883 DOID:12430 DOID:12432 DOID:2049 EFO:0003047 ICD10CM:B19.20 ICD9CM:070.7 MESH:D006526 NCI:C3098 UMLS_CUI:C0019196
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				primary biliary cholangitis IDs primary biliary cholangitis DOID:12236 DOID:1851 EFO:0004267 ICD10CM:K74.3 ICD10CM:K74.5 ICD9CM:571.6 MESH:D008105 NCI:C27167 NCI:C51225 OMIM:PS109720 ORDO:186 UMLS_CUI:C0008312 UMLS_CUI:C0023892

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

13 phenotypes from 4 alleles in 9 genetic backgrounds
5 phenotypes from multigenic genotypes
231 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

8
Radiation induced

1
Targeted

7
Transgenic

1
Genomic Mutations

2 involving Il12a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Null homozygotes have decreased NK cell responses, altered effector T cell differentiation, and increased susceptibility to parasitic infections.

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All GO Annotations

61
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

12
cDNA Data

9
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN il12a

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All Sequences

54
RefSeq

12
UniProt

4
CCDS

CCDS17400.1, CCDS50930.1

Ensembl

ENSMUSG00000027776 (Evidence)
NCBI Gene

16159

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027776	Ensembl Gene Model \| MGI Sequence Detail	7904	C57BL/6J	± kb
transcript	ENSMUST00000029345	Ensembl \| MGI Sequence Detail	1303	Not Applicable
polypeptide	ENSMUSP00000029345	Ensembl \| MGI Sequence Detail	236	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001368 interleukin-12 subunit alpha

(term hierarchy)
PDB

8CR6, 8ODZ, 8OE0, 8PB1
InterPro Domains

IPR009079 Four-helical cytokine-like, core

IPR004281 Interleukin-12 alpha

IPR050676 Interleukin-12 family cytokines
GlyGen

P43431 1 site, 1 N-linked glycan (1 site)

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All nucleic 13

Genomic 3

cDNA 10

Microarray probesets 3

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MGD-MRK-11348, MGD-MRK-11363

Summaries

All 441

Developmental Gene Expression 3

Diseases 1

Gene Ontology 18

Phenotypes 231
Earliest

J:1053 Schoenhaut DS, et al., Cloning and expression of murine IL-12. J Immunol. 1992 Jun 1;148(11):3433-40
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Il12a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29479	Chr3:68598662-68598696 (+)	702 bp
Tssr29480	Chr3:68598700-68598703 (+)	725 bp
Tssr29481	Chr3:68598705-68598744 (+)	748 bp
Tssr29482	Chr3:68598763-68598771 (+)	790 bp
Tssr29483	Chr3:68598829-68598844 (+)	860 bp
Tssr29484	Chr3:68598960-68598983 (+)	995 bp
Tssr29485	Chr3:68599257-68599268 (+)	1,286 bp
Tssr29486	Chr3:68599278-68599290 (+)	1,307 bp
Tssr29487	Chr3:68599388-68599402 (+)	1,418 bp
Tssr29488	Chr3:68599406-68599420 (+)	1,436 bp
Tssr29489	Chr3:68601026-68601037 (+)	3,055 bp
Tssr29490	Chr3:68601072-68601084 (+)	3,101 bp
Tssr29491	Chr3:68601363-68601380 (+)	3,395 bp
Tssr29492	Chr3:68601411-68601422 (+)	3,440 bp
Tssr29493	Chr3:68601428-68601437 (+)	3,456 bp
Tssr29494	Chr3:68605352-68605369 (+)	7,384 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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