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Il12b Gene Detail
Summary
  • Symbol
    Il12b
  • Name
    interleukin 12b
  • Synonyms
    Il-12b, Il-12p40, IL-12 p40, IL-23 subunit p40
  • Feature Type
    protein coding gene
  • IDs
    MGI:96540
    NCBI Gene: 16160
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:44290890-44304860 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 25.94 cM, cytoband A5-B2
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    550 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96540
 protein coding gene Chr11:44290890-44305504 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018180
 protein coding gene Chr11:43233902-43247838 (+)
A/J MGP_AJ_G0018152
 protein coding gene Chr11:41572645-41586584 (+)
AKR/J MGP_AKRJ_G0018116
 protein coding gene Chr11:42795093-42809082 (+)
BALB/cJ MGP_BALBcJ_G0018121
 protein coding gene Chr11:41762668-41776606 (+)
C3H/HeJ MGP_C3HHeJ_G0017934
 protein coding gene Chr11:42824880-42838820 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018575
 protein coding gene Chr11:44519392-44533361 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016230
 protein coding gene Chr11:39612576-39626442 (+)
CAST/EiJ MGP_CASTEiJ_G0017498
 protein coding gene Chr11:42910519-42925384 (+)
CBA/J MGP_CBAJ_G0017907
 protein coding gene Chr11:46619214-46633154 (+)
DBA/2J MGP_DBA2J_G0018017
 protein coding gene Chr11:41338080-41351996 (+)
FVB/NJ MGP_FVBNJ_G0018011
 protein coding gene Chr11:41015999-41029960 (+)
LP/J MGP_LPJ_G0018089
 protein coding gene Chr11:43484162-43498092 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018035
 protein coding gene Chr11:48236885-48252612 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018614
 protein coding gene Chr11:42957065-42970987 (+)
PWK/PhJ MGP_PWKPhJ_G0017278
 protein coding gene Chr11:41389969-41403951 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017071
 protein coding gene Chr11:42769513-42782560 (+)
WSB/EiJ MGP_WSBEiJ_G0017547
 protein coding gene Chr11:42589397-42603367 (+)



Homology
more
  • Human Ortholog
    IL12B, interleukin 12B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL12B, interleukin 12B
  • Synonyms
    CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2
  • Links
    NCBI Gene ID: 3593
    neXtProt AC: NX_P29460
    UniProt: P29460

  • Chr Location
    5q33.3; chr5:159314780-159330863 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human IL12B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    434 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display impaired Th1 responses, defects in IFN gamma secretion and NK cell activity, increased susceptibility to bacterial and parasitic infection, alveolar bone loss, and resistance to chemically induced tumors and to delayed type hypersensitivity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    122
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    1
  • cDNA Data
    13
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004296 Ensembl Gene Model | MGI Sequence Detail 13971 C57BL/6J ±  kb
    transcript ENSMUST00000102796 Ensembl | MGI Sequence Detail 1861 Not Applicable  
    polypeptide ENSMUSP00000099860 Ensembl | MGI Sequence Detail 335 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 9
      cDNA 13
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11349, MGD-MRK-11364
    References
    more
    • Summaries
      All 647
      Developmental Gene Expression 4
      Gene Ontology 27
      Phenotypes 434
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:352543 Delconte RB, et al., Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity. Immunity. 2024 Jun 12;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory