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Il13 Gene Detail
Summary
  • Symbol
    Il13
  • Name
    interleukin 13
  • Synonyms
    Il-13
  • Feature Type
    protein coding gene
  • IDs
    MGI:96541
    NCBI Gene: 16163
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:53522151-53525529 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 31.98 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    169 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96541
 protein coding gene Chr11:53522150-53525529 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018301
 protein coding gene Chr11:53028749-53032127 (-)
A/J MGP_AJ_G0018270
 protein coding gene Chr11:51034684-51038823 (-)
AKR/J MGP_AKRJ_G0018240
 protein coding gene Chr11:52708778-52712156 (-)
BALB/cJ MGP_BALBcJ_G0018241
 protein coding gene Chr11:51392152-51395593 (-)
C3H/HeJ MGP_C3HHeJ_G0018052
 protein coding gene Chr11:52672165-52675550 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018693
 protein coding gene Chr11:54628982-54634192 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016343
 protein coding gene Chr11:48576115-48579512 (-)
CAST/EiJ MGP_CASTEiJ_G0017617
 protein coding gene Chr11:52717072-52722249 (-)
CBA/J MGP_CBAJ_G0018027
 protein coding gene Chr11:57220428-57223832 (-)
DBA/2J MGP_DBA2J_G0018137
 protein coding gene Chr11:50784473-50787851 (-)
FVB/NJ MGP_FVBNJ_G0018129
 protein coding gene Chr11:50426225-50431703 (-)
LP/J MGP_LPJ_G0018211
 protein coding gene Chr11:53482868-53486256 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018153
 protein coding gene Chr11:58521911-58526741 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018735
 protein coding gene Chr11:52735882-52740087 (-)
PWK/PhJ MGP_PWKPhJ_G0017392
 protein coding gene Chr11:51300132-51303503 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017187
 protein coding gene Chr11:52539649-52543017 (-)
WSB/EiJ MGP_WSBEiJ_G0017664
 protein coding gene Chr11:52367769-52371145 (-)



Homology
more
  • Human Ortholog
    IL13, interleukin 13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL13, interleukin 13
  • Synonyms
    IL-13, P600
  • Links
    NCBI Gene ID: 3596
    neXtProt AC: NX_P35225
    UniProt: P35225

  • Chr Location
    5q31.1; chr5:132656263-132661110 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Il13 mouse models; 22 with human IL13 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
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IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    80 phenotypes from 8 alleles in 14 genetic backgrounds
    31 phenotypes from multigenic genotypes
    301 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for knock-out alleles exhibit defects in immune system morphology and physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    739
  • Tissues
    25
  • cDNA Data
    5
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020383 Ensembl Gene Model | MGI Sequence Detail 3379 C57BL/6J ±  kb
    transcript ENSMUST00000020650 Ensembl | MGI Sequence Detail 1205 Not Applicable  
    polypeptide ENSMUSP00000020650 Ensembl | MGI Sequence Detail 131 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 7
      cDNA 5
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11350, MGD-MRK-11365
    References
    more
    • Summaries
      All 490
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 22
      Phenotypes 301
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:353914 Bessell E, et al., Stromal cell and B cell dialogue potentiates IL-33-enriched lymphoid niches to support eosinophil recruitment and function during type 2 immunity. Cell Rep. 2024 Aug 27;43(8):114620
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory