Il1a MGI Mouse Gene Detail - MGI:96542

Symbol

Il1a
Name

interleukin 1 alpha
Synonyms

Il-1a

Feature Type

protein coding gene
IDs

MGI:96542
NCBI Gene: 16175
Member of

Il1 cluster
Alliance

gene page
Transcription Start Sites

41 TSS

Sequence Map

Chr2:129141530-129151892 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 62.90 cM, cytoband F
Mapping Data

57 experiments

SNPs within 2kb

285 from dbSNP Build 142
Strain Annotations

18
RFLP

14

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96542	protein coding gene	Chr2:129141530-129151892 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026487	protein coding gene	Chr2:132680665-132693435 (-)
A/J	MGP_AJ_G0026451	protein coding gene	Chr2:127307130-127317906 (-)
AKR/J	MGP_AKRJ_G0026426	protein coding gene	Chr2:130923244-130934690 (-)
BALB/cJ	MGP_BALBcJ_G0026463	protein coding gene	Chr2:127573701-127584061 (-)
C3H/HeJ	MGP_C3HHeJ_G0026206	protein coding gene	Chr2:131434770-131444936 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026908	protein coding gene	Chr2:136833122-136843324 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024285	protein coding gene	Chr2:122126549-122137156 (-)
CAST/EiJ	MGP_CASTEiJ_G0025667	protein coding gene	Chr2:131689447-131701075 (-)
CBA/J	MGP_CBAJ_G0026186	protein coding gene	Chr2:141897915-141912792 (-)
DBA/2J	MGP_DBA2J_G0026320	protein coding gene	Chr2:126698044-126708417 (-)
FVB/NJ	MGP_FVBNJ_G0026284	protein coding gene	Chr2:125343758-125354736 (-)
LP/J	MGP_LPJ_G0026425	protein coding gene	Chr2:132926245-132936425 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026304	protein coding gene	Chr2:145786790-145798797 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026963	protein coding gene	Chr2:130957471-130968775 (-)
PWK/PhJ	MGP_PWKPhJ_G0025403	protein coding gene	Chr2:126281436-126291826 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025205	protein coding gene	Chr2:130083840-130094028 (-)
WSB/EiJ	MGP_WSBEiJ_G0025741	protein coding gene	Chr2:131883169-131895335 (-)

Human Ortholog

IL1A, interleukin 1 alpha

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL1A, interleukin 1 alpha
Synonyms

IL1, IL-1A, IL-1 alpha, IL1-ALPHA, IL1F1
Links

HGNC:5991

NCBI Gene ID: 3552

neXtProt AC: NX_P01583

UniProt: P01583
Chr Location

2q14.1; chr2:112773925-112784493 (-) GRCh38

MGI Vertebrate Homology

Il1a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IL1A
Gene Tree

Il1a

Diseases

18 with human IL1A associations

				Human Disease	Mouse Models
				acute myeloid leukemia IDs acute myeloid leukemia DOID:9119 DOID:9118 DOID:9171 ICD10CM:C92.0 ICD9CM:205.0 KEGG:05221 MESH:D015470 NCI:C3171 OMIM:601626 UMLS_CUI:C0023467
				Alzheimer's disease IDs Alzheimer's disease DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				autoimmune thrombocytopenic purpura IDs autoimmune thrombocytopenic purpura DOID:8924 DOID:0050124 DOID:2220 ICD10CM:D69.3 ICD9CM:287.31 MESH:D016553 NCI:C3446 OMIM:188030 UMLS_CUI:C0398650
				end stage renal disease IDs end stage renal disease DOID:783
				Fabry disease IDs Fabry disease DOID:14499 ICD10CM:E75.21 MESH:D000795 NCI:C84701 OMIM:301500 UMLS_CUI:C0002986
				graft-versus-host disease IDs graft-versus-host disease DOID:0081267 MESH:D006086 OMIM:614395 ORDO:39812
				interstitial lung disease IDs interstitial lung disease DOID:3082 ICD10CM:J84.9 MESH:D017563 NCI:C164315 OMIM:PS619611 UMLS_CUI:C0206062
				iridocyclitis IDs iridocyclitis DOID:9383 DOID:9376 DOID:9380 ICD10CM:H20.01 ICD9CM:364.01 ICD9CM:364.2 UMLS_CUI:C0007832 UMLS_CUI:C0154909
				juvenile rheumatoid arthritis IDs juvenile rheumatoid arthritis DOID:676 DOID:10129 DOID:1264 DOID:675 ICD10CM:M08.4 ICD9CM:714.3 ICD9CM:714.31 ICD9CM:714.32 ICD9CM:714.33 NCI:C26979 NCI:C61279 OMIM:604302 ORDO:92 UMLS_CUI:C0157916 UMLS_CUI:C0157917 UMLS_CUI:C0157918 UMLS_CUI:C0409667
				keratoconus IDs keratoconus DOID:10126 ICD10CM:H18.6 ICD9CM:371.6 ICD9CM:371.60 MESH:D007640 NCI:C26806 OMIM:148300 OMIM:608586 OMIM:608932 OMIM:609271 OMIM:614622 OMIM:614623 OMIM:614628 OMIM:614629 ORDO:156071 UMLS_CUI:C0022578
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				multiple myeloma IDs multiple myeloma DOID:9538 EFO:0001378 ICD10CM:C90.0 ICD9CM:203.0 MESH:D009101 NCI:C3242 OMIM:254500 ORDO:29073 UMLS_CUI:C0026764
				osteoporosis IDs osteoporosis DOID:11476 EFO:0003882 ICD10CM:M81.0 ICD9CM:733.0 ICD9CM:733.00 MESH:D010024 NCI:C3298 OMIM:166710 UMLS_CUI:C0029456
				pulmonary fibrosis IDs pulmonary fibrosis DOID:3770 MESH:D011658 NCI:C26869 UMLS_CUI:C0034069
				rheumatoid arthritis IDs rheumatoid arthritis DOID:7148 EFO:0000685 ICD10CM:M06.9 ICD9CM:714.0 KEGG:05323 MESH:D001172 NCI:C2884 OMIM:180300 UMLS_CUI:C0003873
				Schnitzler syndrome IDs Schnitzler syndrome DOID:4371 MESH:D019873 UMLS_CUI:C0524988
				type 1 diabetes mellitus IDs type 1 diabetes mellitus DOID:9744 ICD10CM:E10 KEGG:04940 MESH:D003922 NCI:C2986 OMIM:222100 UMLS_CUI:C0011854

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

16 phenotypes from 4 alleles in 4 genetic backgrounds
10 phenotypes from multigenic genotypes
2 images
195 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

7
Radiation induced

1
Targeted

6
Transgenic

2
Genomic Mutations

2 involving Il1a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal tumor vascularization, decreased metastatic potential, and decreased interleukin-1 beta secretion.

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All GO Annotations

96
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

831
Tissues

73
cDNA Data

10
Literature Summary

25

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

2
UniProt

3
CCDS

CCDS16725.1

Ensembl

ENSMUSG00000027399 (Evidence)
NCBI Gene

16175

			Length	Strain/Species	Flank
genomic	16175	NCBI Gene Model \| MGI Sequence Detail	10363	C57BL/6J	± kb
transcript	NM_010554	RefSeq \| MGI Sequence Detail	1974	ZRU/MplStud
polypeptide	P01582	UniProt \| EBI \| MGI Sequence Detail	270	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001135 interleukin-1 alpha

(term hierarchy)
InterPro Domains

IPR008996 Cytokine IL1/FGF

IPR003295 Interleukin-1 alpha

IPR020877 Interleukin-1 conserved site

IPR000975 Interleukin-1 family

IPR003502 Interleukin-1 propeptide
GlyGen

P01582 3 sites

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All nucleic 20

Genomic 2

cDNA 10

Primer pair 5

Other 3

Microarray probesets 3

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MGD-MRK-11351, MGD-MRK-11366

Summaries

All 399

Developmental Gene Expression 25

Gene Ontology 16

Phenotypes 195
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:353556 Park MD, et al., Hematopoietic aging promotes cancer by fueling IL-1-driven emergency myelopoiesis. Science. 2024 Sep 5;:eadn0327

TSS for Il1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26239	Chr2:129152064-129152098 (-)	-189 bp
Tssr26238	Chr2:129151884-129151898 (-)	1 bp
Tssr26237	Chr2:129151091-129151096 (-)	798 bp
Tssr26236	Chr2:129151058-129151088 (-)	819 bp
Tssr26235	Chr2:129151027-129151052 (-)	852 bp
Tssr26234	Chr2:129151010-129151021 (-)	876 bp
Tssr26233	Chr2:129149830-129149858 (-)	2,048 bp
Tssr26232	Chr2:129148712-129148725 (-)	3,173 bp
Tssr26231	Chr2:129148583-129148598 (-)	3,301 bp
Tssr26230	Chr2:129148558-129148569 (-)	3,328 bp
Tssr26229	Chr2:129148515-129148541 (-)	3,364 bp
Tssr26228	Chr2:129148481-129148504 (-)	3,399 bp
Tssr26227	Chr2:129148458-129148472 (-)	3,427 bp
Tssr26226	Chr2:129148421-129148451 (-)	3,456 bp
Tssr26225	Chr2:129148378-129148384 (-)	3,511 bp
Tssr26224	Chr2:129148085-129148099 (-)	3,800 bp
Tssr26223	Chr2:129147833-129147845 (-)	4,053 bp
Tssr26222	Chr2:129147808-129147819 (-)	4,078 bp
Tssr26221	Chr2:129146733-129146775 (-)	5,138 bp
Tssr26220	Chr2:129146714-129146728 (-)	5,171 bp
Tssr26219	Chr2:129146684-129146696 (-)	5,202 bp
Tssr26218	Chr2:129146633-129146647 (-)	5,252 bp
Tssr26217	Chr2:129145714-129145727 (-)	6,171 bp
Tssr26216	Chr2:129145684-129145705 (-)	6,197 bp
Tssr26215	Chr2:129144898-129144910 (-)	6,988 bp
Tssr26214	Chr2:129144875-129144891 (-)	7,009 bp
Tssr26213	Chr2:129143466-129143469 (-)	8,424 bp
Tssr26212	Chr2:129142859-129142866 (-)	9,029 bp
Tssr26211	Chr2:129142800-129142823 (-)	9,080 bp
Tssr26210	Chr2:129142650-129142686 (-)	9,224 bp
Tssr26209	Chr2:129142535-129142569 (-)	9,340 bp
Tssr26208	Chr2:129142449-129142488 (-)	9,423 bp
Tssr26207	Chr2:129142257-129142260 (-)	9,633 bp
Tssr26206	Chr2:129142165-129142182 (-)	9,718 bp
Tssr26205	Chr2:129142111-129142150 (-)	9,761 bp
Tssr26204	Chr2:129142082-129142097 (-)	9,802 bp
Tssr26203	Chr2:129141974-129141992 (-)	9,909 bp
Tssr26202	Chr2:129141911-129141970 (-)	9,951 bp
Tssr26201	Chr2:129141834-129141907 (-)	10,021 bp
Tssr26200	Chr2:129141768-129141788 (-)	10,114 bp
Tssr26199	Chr2:129141727-129141737 (-)	10,160 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24