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Il1r2 Gene Detail
Summary
  • Symbol
    Il1r2
  • Name
    interleukin 1 receptor, type II
  • Synonyms
    CD121b, Il1r-2, IL-1 receptor beta chain
  • Feature Type
    protein coding gene
  • IDs
    MGI:96546
    NCBI Gene: 16178
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:40123872-40164390 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 18.65 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1311 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96546
 protein coding gene Chr1:40113239-40164391 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015964
 protein coding gene Chr1:38857528-38915750 (+)
A/J MGP_AJ_G0015948
 protein coding gene Chr1:37755502-37808070 (+)
AKR/J MGP_AKRJ_G0015903
 protein coding gene Chr1:38247589-38306433 (+)
BALB/cJ MGP_BALBcJ_G0015902
 protein coding gene Chr1:37417115-37471738 (+)
C3H/HeJ MGP_C3HHeJ_G0015735
 protein coding gene Chr1:38536407-38591062 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016355
 protein coding gene Chr1:40450369-40509628 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014077
 protein coding gene Chr1:34702083-34752965 (+)
CAST/EiJ MGP_CASTEiJ_G0015316
 protein coding gene Chr1:38443747-38498635 (+)
CBA/J MGP_CBAJ_G0015707
 protein coding gene Chr1:41634125-41702042 (+)
DBA/2J MGP_DBA2J_G0015808
 protein coding gene Chr1:37043816-37095700 (+)
FVB/NJ MGP_FVBNJ_G0015810
 protein coding gene Chr1:36585635-36640990 (+)
LP/J MGP_LPJ_G0015878
 protein coding gene Chr1:39191809-39248543 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015830
 protein coding gene Chr1:43665181-43725355 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016402
 protein coding gene Chr1:38396643-38452170 (+)
PWK/PhJ MGP_PWKPhJ_G0015099
 protein coding gene Chr1:36867682-36921071 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014881
 protein coding gene Chr1:38339291-38390386 (+)
WSB/EiJ MGP_WSBEiJ_G0015378
 protein coding gene Chr1:38353083-38410574 (+)



Homology
more
  • Human Ortholog
    IL1R2, interleukin 1 receptor type 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL1R2, interleukin 1 receptor type 2
  • Synonyms
    CD121b, CDw121b, IL-1R-2, IL1R2c, IL1RB, IL-1RT-2, IL-1RT2
  • Links
    NCBI Gene ID: 7850
    neXtProt AC: NX_P27930
    UniProt: P27930

  • Chr Location
    2q11.2; chr2:101991960-102028544 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human IL1R2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 5 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show a prolonged inflammatory response in response to IL-1a. Mice show increased CD4+ T cell number and altered CD8 subtype ratio following sRBC immunization. Another null allele shows increased susceptibility to induced arthritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    20
  • cDNA Data
    16
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16178 NCBI Gene Model | MGI Sequence Detail 40519 C57BL/6J ±  kb
    transcript NM_001360800 RefSeq | MGI Sequence Detail 1646 C57BL/6  
    polypeptide P27931 UniProt | EBI | MGI Sequence Detail 410 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11370, MGD-MRK-11372
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:14586 Chizzonite R, et al., Two high-affinity interleukin 1 receptors represent separate gene products. Proc Natl Acad Sci U S A. 1989 Oct;86(20):8029-33
    • Latest
      J:354879 Belbezier A, et al., Interleukin-1 regulates follicular T cells during the germinal center reaction. Front Immunol. 2024;15:1393096
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory