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Il2rb Gene Detail
Summary
  • Symbol
    Il2rb
  • Name
    interleukin 2 receptor, beta chain
  • Synonyms
    CD122, IL-15Rbeta, IL15Rbeta, IL-15 receptor beta chain, IL-2/15Rbeta, Il-2Rbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:96550
    NCBI Gene: 16185
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:78363456-78379471 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.52 cM, cytoband E
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    517 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96550
 protein coding gene Chr15:78363456-78396569 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022045
 protein coding gene Chr15:78677396-78691923 (-)
A/J MGP_AJ_G0022006
 protein coding gene Chr15:75979594-75994103 (-)
AKR/J MGP_AKRJ_G0021981
 protein coding gene Chr15:78069400-78083911 (-)
BALB/cJ MGP_BALBcJ_G0022012
 protein coding gene Chr15:75952510-75967021 (-)
C3H/HeJ MGP_C3HHeJ_G0021783
 protein coding gene Chr15:78085049-78099560 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022455
 protein coding gene Chr15:81778851-81793364 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019985
 protein coding gene Chr15:72477851-72491919 (-)
CAST/EiJ MGP_CASTEiJ_G0021304
 protein coding gene Chr15:78767620-78780065 (-)
CBA/J MGP_CBAJ_G0021748
 protein coding gene Chr15:84297733-84312244 (-)
DBA/2J MGP_DBA2J_G0021877
 protein coding gene Chr15:75463893-75478431 (-)
FVB/NJ MGP_FVBNJ_G0021855
 protein coding gene Chr15:74466256-74480767 (-)
LP/J MGP_LPJ_G0021945
 protein coding gene Chr15:78881947-78898215 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021875
 protein coding gene Chr15:89494973-89510603 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022469
 protein coding gene Chr15:78111788-78126284 (-)
PWK/PhJ MGP_PWKPhJ_G0021046
 protein coding gene Chr15:75462206-75474104 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020883
 protein coding gene Chr15:77887402-77901322 (-)
WSB/EiJ MGP_WSBEiJ_G0021356
 protein coding gene Chr15:78468560-78483756 (-)



Homology
more
  • Human Ortholog
    IL2RB, interleukin 2 receptor subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL2RB, interleukin 2 receptor subunit beta
  • Synonyms
    CD122, IL15RB, IMD63, P70-75
  • Links
    NCBI Gene ID: 3560
    neXtProt AC: NX_P14784
    UniProt: P14784

  • Chr Location
    22q12.3; chr22:37118666-37175118 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human IL2RB associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    53 phenotypes from 5 alleles in 8 genetic backgrounds
    5 phenotypes from multigenic genotypes
    104 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit spontaneous activation of T cells and differentiation of B cells, elevated immunoglobulins including autoantibodies causing hemolytic anemia, granulocytopoiesis, and death after 3 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    19
  • cDNA Data
    18
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068227 Ensembl Gene Model | MGI Sequence Detail 16016 C57BL/6J ±  kb
    transcript ENSMUST00000163494 Ensembl | MGI Sequence Detail 1895 Not Applicable  
    polypeptide ENSMUSP00000127006 Ensembl | MGI Sequence Detail 539 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 18
      Primer pair 2
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11377
    References
    more
    • Summaries
      All 179
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 14
      Phenotypes 104
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory