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Il4 Gene Detail
Summary
  • Symbol
    Il4
  • Name
    interleukin 4
  • Synonyms
    Il-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96556
    NCBI Gene: 16189
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:53503287-53509492 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 31.97 cM
  • Mapping Data
    43 experiments
Strain
Comparison
more
  • SNPs within 2kb
    323 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    4
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96556
 protein coding gene Chr11:53493809-53509496 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018300
 protein coding gene Chr11:52998742-53014350 (-)
A/J MGP_AJ_G0018269
 protein coding gene Chr11:51006405-51022033 (-)
AKR/J MGP_AKRJ_G0018239
 protein coding gene Chr11:52677109-52694704 (-)
BALB/cJ MGP_BALBcJ_G0018240
 protein coding gene Chr11:51363906-51379480 (-)
C3H/HeJ MGP_C3HHeJ_G0018051
 protein coding gene Chr11:52641062-52658717 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018692
 protein coding gene Chr11:54596617-54616468 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016342
 protein coding gene Chr11:48544087-48559578 (-)
CAST/EiJ MGP_CASTEiJ_G0017616
 protein coding gene Chr11:52688747-52704226 (-)
CBA/J MGP_CBAJ_G0018026
 protein coding gene Chr11:57181603-57202811 (-)
DBA/2J MGP_DBA2J_G0018136
 protein coding gene Chr11:50753481-50771775 (-)
FVB/NJ MGP_FVBNJ_G0018128
 protein coding gene Chr11:50396420-50413813 (-)
LP/J MGP_LPJ_G0018210
 protein coding gene Chr11:53443783-53465319 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018152
 protein coding gene Chr11:58490925-58509216 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018734
 protein coding gene Chr11:52706245-52723243 (-)
PWK/PhJ MGP_PWKPhJ_G0017391
 protein coding gene Chr11:51270330-51286076 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017186
 protein coding gene Chr11:52511241-52527247 (-)
WSB/EiJ MGP_WSBEiJ_G0017663
 protein coding gene Chr11:52338803-52354895 (-)



Homology
more
  • Human Ortholog
    IL4, interleukin 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL4, interleukin 4
  • Synonyms
    BCGF-1, BCGF1, BSF-1, BSF1, IL-4
  • Links
    NCBI Gene ID: 3565
    neXtProt AC: NX_P05112
    UniProt: P05112

  • Chr Location
    5q31.1; chr5:132673986-132682678 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Il4 mouse models; 14 with human IL4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 2 models
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    105 phenotypes from 13 alleles in 27 genetic backgrounds
    74 phenotypes from multigenic genotypes
    700 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for knock-out alleles exhibit defects in immune system morphology and physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    108
  • GO References
    59
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    35
  • cDNA Data
    15
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16189 NCBI Gene Model | MGI Sequence Detail 6206 C57BL/6J ±  kb
    transcript NR_027491 RefSeq | MGI Sequence Detail 624 ZRU/MplStud  
    polypeptide P07750 UniProt | EBI | MGI Sequence Detail 140 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 11
      cDNA 15
      Primer pair 8
      Other 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11355, MGD-MRK-11385
    References
    more
    • Summaries
      All 1249
      Developmental Gene Expression 19
      Diseases 3
      Gene Ontology 59
      Phenotypes 700
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:355331 Mao Y, et al., Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance. J Neuroinflammation. 2024 Oct 4;21(1):249
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory