Il6st MGI Mouse Gene Detail - MGI:96560 - interleukin 6 signal transducer

Symbol

Il6st
Name

interleukin 6 signal transducer
Synonyms

5133400A03Rik, CD130, D13Ertd699e, gp130

Feature Type

protein coding gene
IDs

MGI:96560
NCBI Gene: 16195
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr13:112600604-112643394 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 63.73 cM
Mapping Data

4 experiments

SNPs within 2kb

1236 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96560	protein coding gene	Chr13:112600604-112646620 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020936	protein coding gene	Chr13:115025884-115066341 (+)
A/J	MGP_AJ_G0020886	protein coding gene	Chr13:110430601-110477148 (+)
AKR/J	MGP_AKRJ_G0020861	protein coding gene	Chr13:113768957-113809884 (+)
BALB/cJ	MGP_BALBcJ_G0020886	protein coding gene	Chr13:111129220-111174772 (+)
C3H/HeJ	MGP_C3HHeJ_G0020675	protein coding gene	Chr13:113560453-113601541 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021322	protein coding gene	Chr13:118447105-118488425 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018891	protein coding gene	Chr13:105734420-105780095 (+)
CAST/EiJ	MGP_CASTEiJ_G0020195	protein coding gene	Chr13:113177176-113225763 (+)
CBA/J	MGP_CBAJ_G0020637	protein coding gene	Chr13:123020405-123062652 (+)
DBA/2J	MGP_DBA2J_G0020760	protein coding gene	Chr13:110148371-110189128 (+)
FVB/NJ	MGP_FVBNJ_G0020744	protein coding gene	Chr13:108840955-108886979 (+)
LP/J	MGP_LPJ_G0020836	protein coding gene	Chr13:115071191-115111341 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020772	protein coding gene	Chr13:123299808-123347564 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021358	protein coding gene	Chr13:113211916-113257541 (+)
PWK/PhJ	MGP_PWKPhJ_G0019948	protein coding gene	Chr13:108884775-108930230 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019770	protein coding gene	Chr13:109538148-109590868 (+)
WSB/EiJ	MGP_WSBEiJ_G0020252	protein coding gene	Chr13:113825151-113871082 (+)

Human Ortholog

IL6ST, interleukin 6 cytokine family signal transducer

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL6ST, interleukin 6 cytokine family signal transducer
Synonyms

CD130, CDW130, GP130, HIES4, HIES4A, HIES4B, IL-6RB, IMD94, sGP130, STWS2
Links

HGNC:6021

NCBI Gene ID: 3572

neXtProt AC: NX_P40189

UniProt: P40189
Chr Location

5q11.2; chr5:55935095-55995022 (-) GRCh38

MGI Vertebrate Homology

Il6st stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IL6ST
Gene Tree

Il6st

Diseases

2 with Il6st mouse models; 4 with human IL6ST associations

Human Disease

Mouse Models

rheumatoid arthritis

IDs

View 1 model

stomach cancer

IDs

View 1 model

arteriosclerosis

IDs

hyper IgE recurrent infection syndrome 4

IDs

hyperandrogenism

IDs

primary immunodeficiency disease

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

164 phenotypes from 10 alleles in 12 genetic backgrounds
18 phenotypes from multigenic genotypes
190 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Endonuclease-mediated

6
Gene trapped

7
Targeted

17
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

80 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations show myocardial and hematological defects and die between embryonic day 12.5 and term. Conditional mutants show female infertility and neurological, cardiac, hematopoietic, immunological, hepatic, and lung defects.

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All GO Annotations

88
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

875
Tissues

93
cDNA Data

20
Literature Summary

27

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase il6st

ZFIN il6st

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All Sequences

78
RefSeq

4
UniProt

10
CCDS

CCDS26773.1

Ensembl

ENSMUSG00000021756 (Evidence)
NCBI Gene

16195

			Length	Strain/Species	Flank
genomic	16195	NCBI Gene Model \| MGI Sequence Detail	42791	C57BL/6J	± kb
transcript	NM_010560	RefSeq \| MGI Sequence Detail	5452	ZRU/MplStud
polypeptide	Q00560	UniProt \| EBI \| MGI Sequence Detail	917	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000001868 interleukin-6 receptor subunit beta

(term hierarchy)
PDB

2BBU, 2HMH, 4GL9, 6C5X, 7Z0L, 8QY4, 8QY5, 8QY6
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR010457 Immunoglobulin C2-set-like, ligand-binding

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site

IPR050379 Type I Cytokine Receptor

IPR015321 Type I cytokine receptor, cytokine-binding domain
GlyGen

Q00560 11 sites, 10 N-linked glycans (10 sites), 1 O-linked glycan (1 site)

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All nucleic 29

cDNA 20

Primer pair 6

Other 3

Microarray probesets 8

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MGD-MRK-11393, MGI:1277187, MGI:1918567, MGI:3034594, MGI:3034705

Summaries

All 294

Developmental Gene Expression 27

Diseases 2

Gene Ontology 16

Phenotypes 190
Earliest

J:29552 Gearing DP, et al., Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991 Oct;10(10):2839-48
Latest

J:354960 Chang Y, et al., TGF-beta specifies T(FH) versus T(H)17 cell fates in murine CD4(+) T cells through c-Maf. Sci Immunol. 2024 Mar;9(93):eadd4818

TSS for Il6st:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121119	Chr13:112600133-112600172 (+)	-451 bp
Tssr121120	Chr13:112600618-112600696 (+)	53 bp
Tssr121121	Chr13:112601055-112601063 (+)	455 bp
Tssr121122	Chr13:112602375-112602383 (+)	1,775 bp
Tssr121123	Chr13:112603396-112603414 (+)	2,801 bp
Tssr121124	Chr13:112604002-112604009 (+)	3,402 bp
Tssr121125	Chr13:112604038-112604055 (+)	3,443 bp
Tssr121126	Chr13:112611345-112611352 (+)	10,745 bp
Tssr121127	Chr13:112616568-112616595 (+)	15,978 bp
Tssr121128	Chr13:112616605-112616631 (+)	16,014 bp
Tssr121129	Chr13:112617997-112618010 (+)	17,400 bp
Tssr121130	Chr13:112618693-112618725 (+)	18,105 bp
Tssr121131	Chr13:112625107-112625144 (+)	24,522 bp
Tssr121132	Chr13:112626509-112626517 (+)	25,909 bp
Tssr121133	Chr13:112631772-112631794 (+)	31,179 bp
Tssr121134	Chr13:112640630-112640643 (+)	40,033 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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