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Inhbb Gene Detail
Summary
  • Symbol
    Inhbb
  • Name
    inhibin beta-B
  • Synonyms
    activin beta-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:96571
    NCBI Gene: 16324
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:119343195-119349978 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 52.29 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96571
 protein coding gene Chr1:119343193-119349978 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016394
 protein coding gene Chr1:122150954-122163049 (-)
A/J MGP_AJ_G0016377
 protein coding gene Chr1:117786374-117793155 (-)
AKR/J MGP_AKRJ_G0016342
 protein coding gene Chr1:121265115-121271899 (-)
BALB/cJ MGP_BALBcJ_G0016337
 protein coding gene Chr1:118049666-118056428 (-)
C3H/HeJ MGP_C3HHeJ_G0016163
 protein coding gene Chr1:121431058-121439122 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016798
 protein coding gene Chr1:126840438-126848831 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014511
 protein coding gene Chr1:111455427-111462080 (-)
CAST/EiJ MGP_CASTEiJ_G0015744
 protein coding gene Chr1:120196525-120201989 (-)
CBA/J MGP_CBAJ_G0016136
 protein coding gene Chr1:131207144-131217012 (-)
DBA/2J MGP_DBA2J_G0016242
 protein coding gene Chr1:116803607-116810391 (-)
FVB/NJ MGP_FVBNJ_G0016241
 protein coding gene Chr1:115542902-115548636 (-)
LP/J MGP_LPJ_G0016313
 protein coding gene Chr1:123500048-123506828 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016266
 protein coding gene Chr1:136924967-136931763 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016834
 protein coding gene Chr1:120962274-120970025 (-)
PWK/PhJ MGP_PWKPhJ_G0015530
 protein coding gene Chr1:115792654-115799471 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015318
 protein coding gene Chr1:119851045-119861967 (-)
WSB/EiJ MGP_WSBEiJ_G0015806
 protein coding gene Chr1:120856120-120862957 (-)



Homology
more
  • Human Ortholog
    INHBB, inhibin subunit beta B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INHBB, inhibin subunit beta B
  • Links
    NCBI Gene ID: 3625
    neXtProt AC: NX_P09529
    UniProt: P09529

  • Chr Location
    2q14.2; chr2:120346136-120351803 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 3 alleles in 4 genetic backgrounds
    15 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Some homozygotes for targeted null mutations exhibit open eyes at birth and impaired maternal nuturing. Mutant females for one line exhibit extended gestation length, retarded mammary duct elongation and alveolar morphogenesis, and are unable to nurse their pups.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    987
  • Tissues
    164
  • cDNA Data
    67
  • Literature Summary
    57
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037035 Ensembl Gene Model | MGI Sequence Detail 6784 C57BL/6J ±  kb
    transcript ENSMUST00000038765 Ensembl | MGI Sequence Detail 4255 Not Applicable  
    polypeptide ENSMUSP00000044918 Ensembl | MGI Sequence Detail 411 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 93
      Genomic 8
      cDNA 76
      Primer pair 8
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11408
    References
    more
    • Summaries
      All 138
      Developmental Gene Expression 57
      Gene Ontology 13
      Phenotypes 36
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory