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Irf1 Gene Detail
Summary
  • Symbol
    Irf1
  • Name
    interferon regulatory factor 1
  • Synonyms
    Irf-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96590
    NCBI Gene: 16362
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:53660841-53669200 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 32.00 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    262 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96590
 protein coding gene Chr11:53660841-53669200 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018304
 protein coding gene Chr11:53188448-53196807 (+)
A/J MGP_AJ_G0018273
 protein coding gene Chr11:51176180-51184539 (+)
AKR/J MGP_AKRJ_G0018243
 protein coding gene Chr11:52855618-52863977 (+)
BALB/cJ MGP_BALBcJ_G0018244
 protein coding gene Chr11:51531491-51540156 (+)
C3H/HeJ MGP_C3HHeJ_G0018055
 protein coding gene Chr11:52825546-52833905 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018696
 protein coding gene Chr11:54790564-54798923 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016346
 protein coding gene Chr11:48706888-48715085 (+)
CAST/EiJ MGP_CASTEiJ_G0017620
 protein coding gene Chr11:52866530-52889182 (+)
CBA/J MGP_CBAJ_G0018030
 protein coding gene Chr11:57395944-57404303 (+)
DBA/2J MGP_DBA2J_G0018140
 protein coding gene Chr11:50922593-50930969 (+)
FVB/NJ MGP_FVBNJ_G0018132
 protein coding gene Chr11:50566856-50575215 (+)
LP/J MGP_LPJ_G0018214
 protein coding gene Chr11:53635714-53644877 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018156
 protein coding gene Chr11:58674787-58683145 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018738
 protein coding gene Chr11:52885706-52895414 (+)
PWK/PhJ MGP_PWKPhJ_G0017395
 protein coding gene Chr11:51441920-51461148 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017190
 protein coding gene Chr11:52676276-52684586 (+)
WSB/EiJ MGP_WSBEiJ_G0017667
 protein coding gene Chr11:52521141-52531505 (+)



Homology
more
  • Human Ortholog
    IRF1, interferon regulatory factor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRF1, interferon regulatory factor 1
  • Synonyms
    IMD117, IRF-1, MAR
  • Links
    NCBI Gene ID: 3659
    neXtProt AC: NX_P10914
    UniProt: P10914

  • Chr Location
    5q31.1; chr5:132440440-132508719 (-)  GRCh38
Human Diseases
more
  • Diseases
    7 with human IRF1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 5 alleles in 9 genetic backgrounds
    18 phenotypes from multigenic genotypes
    178 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene leads to reduced CD8+ T cell number and altered response to viral infection and may cause alterations in cytokine levels, CD4+ cell subset homeostasis, blood vessel healing, DNA repair, and susceptibility to induced lymphomas, arthritis and autoimmune encephalitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    77
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    853
  • Tissues
    74
  • cDNA Data
    160
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16362 NCBI Gene Model | MGI Sequence Detail 8360 C57BL/6J ±  kb
    transcript NM_008390 RefSeq | MGI Sequence Detail 2151 ZRU/MplStud  
    polypeptide P15314 UniProt | EBI | MGI Sequence Detail 329 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000002043 interferon regulatory factor 1
      (term hierarchy)
    • PDB
      1IF1
    • InterPro Domains
      IPR017431 Interferon regulatory factor-1/2
      IPR019817 Interferon regulatory factor, conserved site
      IPR001346 Interferon regulatory factor, DNA-binding domain
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 179
      Genomic 12
      cDNA 163
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11464, MGD-MRK-11465, MGI:2144403
    References
    more
    • Summaries
      All 290
      Developmental Gene Expression 15
      Gene Ontology 22
      Phenotypes 178
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:352683 Purbey PK, et al., Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity. Cell Rep. 2024 Jun 25;43(6):114289
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory