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Itga4 Gene Detail
Summary
  • Symbol
    Itga4
  • Name
    integrin alpha 4
  • Synonyms
    VLA-4 receptor, alpha 4 subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:96603
    NCBI Gene: 16401
  • Alliance
    gene page
  • Transcription Start Sites
    34 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:79085770-79163467 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 47.38 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2306 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96603
 protein coding gene Chr2:79084767-79163467 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025876
 protein coding gene Chr2:79785375-79874887 (+)
A/J MGP_AJ_G0025853
 protein coding gene Chr2:76708335-76786572 (+)
AKR/J MGP_AKRJ_G0025822
 protein coding gene Chr2:78715383-78798316 (+)
BALB/cJ MGP_BALBcJ_G0025849
 protein coding gene Chr2:76833002-76913242 (+)
C3H/HeJ MGP_C3HHeJ_G0025608
 protein coding gene Chr2:78938365-79022662 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026295
 protein coding gene Chr2:82148692-82241438 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023698
 protein coding gene Chr2:73964094-74038811 (+)
CAST/EiJ MGP_CASTEiJ_G0025070
 protein coding gene Chr2:79356984-79443700 (+)
CBA/J MGP_CBAJ_G0025589
 protein coding gene Chr2:85092775-85186027 (+)
DBA/2J MGP_DBA2J_G0025720
 protein coding gene Chr2:76260266-76339375 (+)
FVB/NJ MGP_FVBNJ_G0025682
 protein coding gene Chr2:75631334-75707565 (+)
LP/J MGP_LPJ_G0025808
 protein coding gene Chr2:79637817-79719448 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025713
 protein coding gene Chr2:86951045-87038443 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026351
 protein coding gene Chr2:78880294-78966347 (+)
PWK/PhJ MGP_PWKPhJ_G0024813
 protein coding gene Chr2:76205797-76284427 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024619
 protein coding gene Chr2:79145833-79229760 (+)
WSB/EiJ MGP_WSBEiJ_G0025139
 protein coding gene Chr2:79504753-79593381 (+)



Homology
more
  • Human Ortholog
    ITGA4, integrin subunit alpha 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGA4, integrin subunit alpha 4
  • Synonyms
    CD49D, IA4
  • Links
    NCBI Gene ID: 3676
    neXtProt AC: NX_P13612
    UniProt: P13612

  • Chr Location
    2q31.3; chr2:181457202-181538940 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ITGA4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 4 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene exhibit embryonic lethality either due to failure of chorioallantoic fusion or cardiac abnormalities, including hemorrhage around the heart and defects in epicardium formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1429
  • Tissues
    507
  • cDNA Data
    85
  • Literature Summary
    72
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027009 Ensembl Gene Model | MGI Sequence Detail 77698 C57BL/6J ±  kb
    transcript ENSMUST00000099972 Ensembl | MGI Sequence Detail 9767 Not Applicable  
    polypeptide ENSMUSP00000099718 Ensembl | MGI Sequence Detail 1032 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000009129 integrin alpha-4
      (term hierarchy)
    • InterPro Domains
      IPR013517 FG-GAP repeat
      IPR013519 Integrin alpha beta-propellor
      IPR000413 Integrin alpha chain
      IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
      IPR013649 Integrin alpha, first immunoglubulin-like domain
      IPR028994 Integrin alpha, N-terminal
      IPR048285 Integrin alpha, second immunoglobulin-like domain
      IPR048286 Integrin alpha, third immunoglobulin-like domain
      IPR032695 Integrin domain superfamily
    • GlyGen
      Q00651 19 sites, 12 N-linked glycans (13 sites)
    Molecular
    Reagents
    less
    • All nucleic 115
      Genomic 16
      cDNA 91
      Primer pair 5
      Other 3

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-11482
    References
    more
    • Summaries
      All 237
      Developmental Gene Expression 72
      Gene Ontology 16
      Phenotypes 65
    • Earliest
      J:9952 Holzmann B, et al., Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel. EMBO J. 1989 Jun;8(6):1735-41
    • Latest
      J:353479 Erickson AG, et al., Motor innervation directs the correct development of the mouse sympathetic nervous system. Nat Commun. 2024 Aug 16;15(1):7065
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory