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Itgam Gene Detail
Summary
  • Symbol
    Itgam
  • Name
    integrin alpha M
  • Synonyms
    Cd11b, CD11b/CD18, CD11B (p170), complement component receptor 3 alpha, complement receptor type 3, CR3, F730045J24Rik, Ly-40, Mac-1, Mac-1a, Mac-1 alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:96607
    NCBI Gene: 16409
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127661812-127717663 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.93 cM, cytoband F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1476 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96607
 protein coding gene Chr7:127661812-127717663 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033070
 protein coding gene Chr7:132464519-132526061 (+)
A/J MGP_AJ_G0033053
 protein coding gene Chr7:128908509-128963130 (+)
AKR/J MGP_AKRJ_G0032985
 protein coding gene Chr7:132260880-132323867 (+)
BALB/cJ MGP_BALBcJ_G0033054
 protein coding gene Chr7:128567456-128627107 (+)
C3H/HeJ MGP_C3HHeJ_G0032768
 protein coding gene Chr7:132153468-132215646 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033564
 protein coding gene Chr7:137621345-137685831 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030536
 protein coding gene Chr7:130090750-130145490 (+)
CAST/EiJ MGP_CASTEiJ_G0032097
 protein coding gene Chr7:123945852-124004522 (+)
CBA/J MGP_CBAJ_G0032741
 protein coding gene Chr7:142304584-142374775 (+)
DBA/2J MGP_DBA2J_G0032893
 protein coding gene Chr7:126891506-126945722 (+)
FVB/NJ MGP_FVBNJ_G0032846
 protein coding gene Chr7:126749290-126810905 (+)
LP/J MGP_LPJ_G0032987
 protein coding gene Chr7:133934814-133996034 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032878
 protein coding gene Chr7:143369067-143429668 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033583
 protein coding gene Chr7:131238709-131297422 (+)
PWK/PhJ MGP_PWKPhJ_G0031804
 protein coding gene Chr7:119895228-119952819 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031650
 protein coding gene Chr7:118047935-118098342 (+)
WSB/EiJ MGP_WSBEiJ_G0032209
 protein coding gene Chr7:132206824-132269089 (+)



Homology
more
  • Human Ortholog
    ITGAM, integrin subunit alpha M
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGAM, integrin subunit alpha M
  • Synonyms
    CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6
  • Links
    NCBI Gene ID: 3684
    neXtProt AC: NX_P11215
    UniProt: P11215

  • Chr Location
    16p11.2; chr16:31259967-31332892 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human ITGAM associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 7 alleles in 11 genetic backgrounds
    1 phenotype from multigenic genotypes
    234 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit reduced staphylococcal enterotoxin-induced T cell proliferation, reduced neutrophil adhesion to fibrinogen, and defective homotypic aggregation and reduced degranulation of neutrophils.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    37
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    32
  • cDNA Data
    38
  • Literature Summary
    88
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16409 NCBI Gene Model | MGI Sequence Detail 55852 C57BL/6J ±  kb
    transcript NM_001082960 RefSeq | MGI Sequence Detail 4682 C57BL/6  
    polypeptide P05555 UniProt | EBI | MGI Sequence Detail 1153 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 3
      cDNA 38
      Primer pair 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11486, MGD-MRK-11982, MGD-MRK-12094, MGI:2444489
    References
    more
    • Summaries
      All 481
      Developmental Gene Expression 88
      Gene Ontology 37
      Phenotypes 234
    • Earliest
      J:6186 Springer T, et al., Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol. 1979 Apr;9(4):301-6
    • Latest
      J:354496 Stark K, et al., Antibodies and complement are key drivers of thrombosis. Immunity. 2024 Sep 10;57(9):2140-2156.e10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory