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Itgav Gene Detail
Summary
  • Symbol
    Itgav
  • Name
    integrin alpha V
  • Synonyms
    1110004F14Rik, 2610028E01Rik, alphav-integrin, CD51, D430040G12Rik, vitronectin receptor alpha polypeptide (VNRA)
  • Feature Type
    protein coding gene
  • IDs
    MGI:96608
    NCBI Gene: 16410
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:83554796-83637261 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 49.33 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1329 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96608
 protein coding gene Chr2:83554741-83637261 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025892
 protein coding gene Chr2:84379091-84468010 (+)
A/J MGP_AJ_G0025869
 protein coding gene Chr2:81146286-81241614 (+)
AKR/J MGP_AKRJ_G0025838
 protein coding gene Chr2:83235281-83324250 (+)
BALB/cJ MGP_BALBcJ_G0025865
 protein coding gene Chr2:81275838-81361798 (+)
C3H/HeJ MGP_C3HHeJ_G0025624
 protein coding gene Chr2:83512711-83601099 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026311
 protein coding gene Chr2:86954376-87043825 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023714
 protein coding gene Chr2:78061390-78144396 (+)
CAST/EiJ MGP_CASTEiJ_G0025086
 protein coding gene Chr2:83975378-84063480 (+)
CBA/J MGP_CBAJ_G0025605
 protein coding gene Chr2:90133691-90228262 (+)
DBA/2J MGP_DBA2J_G0025736
 protein coding gene Chr2:80727880-80813333 (+)
FVB/NJ MGP_FVBNJ_G0025698
 protein coding gene Chr2:79946768-80035084 (+)
LP/J MGP_LPJ_G0025824
 protein coding gene Chr2:84219798-84319072 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025729
 protein coding gene Chr2:92359931-92451690 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026367
 protein coding gene Chr2:83445663-83535464 (+)
PWK/PhJ MGP_PWKPhJ_G0024829
 protein coding gene Chr2:80512500-80597793 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024634
 protein coding gene Chr2:83581278-83668883 (+)
WSB/EiJ MGP_WSBEiJ_G0025155
 protein coding gene Chr2:84102161-84191261 (+)



Homology
more
  • Human Ortholog
    ITGAV, integrin subunit alpha V
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGAV, integrin subunit alpha V
  • Synonyms
    CD51, MSK8, VNRA, VTNR
  • Links
    NCBI Gene ID: 3685
    neXtProt AC: NX_P06756
    UniProt: P06756

  • Chr Location
    2q32.1; chr2:186590010-186680901 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ITGAV associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    75 phenotypes from 3 alleles in 8 genetic backgrounds
    11 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit placental defects, intracerebral and intestinal hemorrhages, and cleft palate, resulting in death occurring as early as midgestation and as late as shortly after birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    151
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    931
  • Tissues
    72
  • cDNA Data
    158
  • Literature Summary
    40
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16410 NCBI Gene Model | MGI Sequence Detail 82466 C57BL/6J ±  kb
    transcript NM_008402 RefSeq | MGI Sequence Detail 7000 ZRU/MplStud  
    polypeptide P43406 UniProt | EBI | MGI Sequence Detail 1044 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000009135 integrin alpha-V
      (term hierarchy)
    • InterPro Domains
      IPR013517 FG-GAP repeat
      IPR013519 Integrin alpha beta-propellor
      IPR000413 Integrin alpha chain
      IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
      IPR013649 Integrin alpha, first immunoglubulin-like domain
      IPR028994 Integrin alpha, N-terminal
      IPR048285 Integrin alpha, second immunoglobulin-like domain
      IPR048286 Integrin alpha, third immunoglobulin-like domain
      IPR032695 Integrin domain superfamily
    • GlyGen
      P43406 14 sites, 21 N-linked glycans (9 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 167
      cDNA 160
      Primer pair 5
      Other 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-11487, MGI:1923548, MGI:1923608, MGI:2445000
    References
    more
    • Summaries
      All 222
      Developmental Gene Expression 40
      Gene Ontology 31
      Phenotypes 53
    • Earliest
      J:10951 Moulder K, et al., The mouse vitronectin receptor is a T cell activation antigen. J Exp Med. 1991 Feb 1;173(2):343-7
    • Latest
      J:352471 Yoshida S, et al., Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development. Endocrinology. 2024 Jul 1;165(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory