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Kcna2 Gene Detail
Summary
  • Symbol
    Kcna2
  • Name
    potassium voltage-gated channel, shaker-related subfamily, member 2
  • Synonyms
    Akr6a4, Kca1-2, Kv1.2, Mk-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96659
    NCBI Gene: 16490
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:107008462-107022321 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.61 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    257 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96659
 protein coding gene Chr3:106998203-107022321 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027740
 protein coding gene Chr3:108571249-108586068 (+)
A/J MGP_AJ_G0027700
 protein coding gene Chr3:105131386-105145339 (+)
AKR/J MGP_AKRJ_G0027665
 protein coding gene Chr3:107701773-107717477 (+)
BALB/cJ MGP_BALBcJ_G0027712
 protein coding gene Chr3:104828382-104838186 (+)
C3H/HeJ MGP_C3HHeJ_G0027442
 protein coding gene Chr3:108044548-108058329 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028156
 protein coding gene Chr3:112650611-112666701 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025494
 protein coding gene Chr3:101286510-101300280 (+)
CAST/EiJ MGP_CASTEiJ_G0026898
 protein coding gene Chr3:107404251-107418177 (+)
CBA/J MGP_CBAJ_G0027417
 protein coding gene Chr3:116437842-116457234 (+)
DBA/2J MGP_DBA2J_G0027559
 protein coding gene Chr3:104334708-104348467 (+)
FVB/NJ MGP_FVBNJ_G0027527
 protein coding gene Chr3:102214637-102224385 (+)
LP/J MGP_LPJ_G0027666
 protein coding gene Chr3:109990563-110005224 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027557
 protein coding gene Chr3:122571508-122586476 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028211
 protein coding gene Chr3:107283511-107293287 (+)
PWK/PhJ MGP_PWKPhJ_G0026624
 protein coding gene Chr3:104054931-104064669 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026444
 protein coding gene Chr3:105425989-105434168 (+)
WSB/EiJ MGP_WSBEiJ_G0026978
 protein coding gene Chr3:107818878-107832796 (+)



Homology
more
  • Human Ortholog
    KCNA2, potassium voltage-gated channel subfamily A member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNA2, potassium voltage-gated channel subfamily A member 2
  • Synonyms
    DEE32, EIEE32, HBK5, HK4, HUKIV, KV1.2, MK2, NGK1, RBK2
  • Links
    NCBI Gene ID: 3737
    neXtProt AC: NX_P16389
    UniProt: P16389

  • Chr Location
    1p13.3; chr1:110519837-110631474 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KCNA2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 4 alleles in 6 genetic backgrounds
    1 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal lethality, increased susceptibility to spontaneous and chemically-induced seizures and altered neuron electrophysiology. Mice homozygous for an ENU-induced allele exhibit abnormal gait, impaired coordination, and premature lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    29
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    48
  • cDNA Data
    43
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040724 Ensembl Gene Model | MGI Sequence Detail 13860 C57BL/6J ±  kb
    transcript ENSMUST00000197470 Ensembl | MGI Sequence Detail 4370 Not Applicable  
    polypeptide ENSMUSP00000143798 Ensembl | MGI Sequence Detail 499 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000000810 voltage-gated potassium channel subunit KCNA2
      (term hierarchy)
    • PDB
      5WIE
    • InterPro Domains
      IPR000210 BTB/POZ domain
      IPR005821 Ion transport domain
      IPR003131 Potassium channel tetramerisation-type BTB domain
      IPR003968 Potassium channel, voltage dependent, Kv
      IPR003972 Potassium channel, voltage dependent, Kv1
      IPR004049 Potassium channel, voltage dependent, Kv1.2
      IPR011333 SKP1/BTB/POZ domain superfamily
      IPR027359 Voltage-dependent channel domain superfamily
    • GlyGen
      P63141 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 6
      cDNA 44
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11555, MGD-MRK-11563, MGD-MRK-12249
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 29
      Phenotypes 24
    • Earliest
      J:40342 Yokoyama S, et al., Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs. FEBS Lett. 1989 Dec 18;259(1):37-42
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory