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Kcnb1 Gene Detail
Summary
  • Symbol
    Kcnb1
  • Name
    potassium voltage gated channel, Shab-related subfamily, member 1
  • Synonyms
    Kcr1-1, Kv2.1, Shab
  • Feature Type
    protein coding gene
  • IDs
    MGI:96666
    NCBI Gene: 16500
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:166937889-167032075 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 87.22 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2648 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96666
 protein coding gene Chr2:166937889-167032088 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026909
 protein coding gene Chr2:172805773-172898922 (-)
A/J MGP_AJ_G0026876
 protein coding gene Chr2:165710592-165797389 (-)
AKR/J MGP_AKRJ_G0026847
 protein coding gene Chr2:170644351-170734840 (-)
BALB/cJ MGP_BALBcJ_G0026885
 protein coding gene Chr2:166056115-166142552 (-)
C3H/HeJ MGP_C3HHeJ_G0026627
 protein coding gene Chr2:171011139-171101625 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027332
 protein coding gene Chr2:177829367-177928696 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024703
 protein coding gene Chr2:159036451-159123156 (-)
CAST/EiJ MGP_CASTEiJ_G0026085
 protein coding gene Chr2:171474044-171562912 (-)
CBA/J MGP_CBAJ_G0026604
 protein coding gene Chr2:184353988-184444795 (-)
DBA/2J MGP_DBA2J_G0026742
 protein coding gene Chr2:164827627-164913831 (-)
FVB/NJ MGP_FVBNJ_G0026708
 protein coding gene Chr2:163335426-163424548 (-)
LP/J MGP_LPJ_G0026843
 protein coding gene Chr2:172828197-172920375 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026727
 protein coding gene Chr2:187753813-187844343 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027389
 protein coding gene Chr2:170549582-170641902 (-)
PWK/PhJ MGP_PWKPhJ_G0025822
 protein coding gene Chr2:164482293-164569318 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025623
 protein coding gene Chr2:169496978-169590158 (-)
WSB/EiJ MGP_WSBEiJ_G0026158
 protein coding gene Chr2:171455003-171549020 (-)



Homology
more
  • Human Ortholog
    KCNB1, potassium voltage-gated channel subfamily B member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNB1, potassium voltage-gated channel subfamily B member 1
  • Synonyms
    DEE26, DRK1, Kv2.1
  • Links
    NCBI Gene ID: 3745
    neXtProt AC: NX_Q14721
    UniProt: Q14721

  • Chr Location
    20q13.13; chr20:49293394-49484297 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KCNB1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show reduced fasting glucose levels, hyperinsulinemia, improved glucose tolerance, and enhanced insulin secretion. Mice homozygous for another null allele exhibit loss of photoreceptors with increased apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    106
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    44
  • cDNA Data
    8
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050556 Ensembl Gene Model | MGI Sequence Detail 94187 C57BL/6J ±  kb
    transcript ENSMUST00000207917 Ensembl | MGI Sequence Detail 11153 Not Applicable  
    polypeptide ENSMUSP00000147093 Ensembl | MGI Sequence Detail 857 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000000722 voltage-gated potassium channel KCNB1
      (term hierarchy)
    • InterPro Domains
      IPR000210 BTB/POZ domain
      IPR005821 Ion transport domain
      IPR003131 Potassium channel tetramerisation-type BTB domain
      IPR003968 Potassium channel, voltage dependent, Kv
      IPR003973 Potassium channel, voltage dependent, Kv2
      IPR004350 Potassium channel, voltage dependent, Kv2.1
      IPR003971 Potassium channel, voltage dependent, Kv9
      IPR011333 SKP1/BTB/POZ domain superfamily
      IPR027359 Voltage-dependent channel domain superfamily
    • GlyGen
      Q03717 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 9
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11570, MGD-MRK-11579, MGD-MRK-14396
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 15
      Gene Ontology 13
      Phenotypes 30
    • Earliest
      J:10462 Wei A, et al., K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse. Science. 1990 May 4;248(4955):599-603
    • Latest
      J:353818 Smith CC, et al., Kv2 channels do not function as canonical delayed rectifiers in spinal motoneurons. iScience. 2024 Aug 16;27(8):110444
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory