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Kdr Gene Detail
Summary
  • Symbol
    Kdr
  • Name
    kinase insert domain protein receptor
  • Synonyms
    Flk-1, Flk1, orv, vascular endothelial growth factor receptor- 2, VEGFR-2, VEGFR2, VEGF receptor-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96683
    NCBI Gene: 16542
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:76093487-76139118 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 40.23 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1260 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96683
 protein coding gene Chr5:76093487-76139880 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029639
 protein coding gene Chr5:76105867-76152652 (-)
A/J MGP_AJ_G0029607
 protein coding gene Chr5:73195890-73241935 (-)
AKR/J MGP_AKRJ_G0029555
 protein coding gene Chr5:75578596-75623933 (-)
BALB/cJ MGP_BALBcJ_G0029616
 protein coding gene Chr5:73918076-73964082 (-)
C3H/HeJ MGP_C3HHeJ_G0029339
 protein coding gene Chr5:75965056-76011465 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030070
 protein coding gene Chr5:79160881-79210489 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027311
 protein coding gene Chr5:68864705-68909947 (-)
CAST/EiJ MGP_CASTEiJ_G0028747
 protein coding gene Chr5:75124990-75172990 (-)
CBA/J MGP_CBAJ_G0029308
 protein coding gene Chr5:81727995-81776818 (-)
DBA/2J MGP_DBA2J_G0029453
 protein coding gene Chr5:73273735-73319659 (-)
FVB/NJ MGP_FVBNJ_G0029414
 protein coding gene Chr5:72435976-72481493 (-)
LP/J MGP_LPJ_G0029540
 protein coding gene Chr5:76525274-76573961 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029442
 protein coding gene Chr5:84933924-84980837 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030103
 protein coding gene Chr5:75136696-75184118 (-)
PWK/PhJ MGP_PWKPhJ_G0028470
 protein coding gene Chr5:72275191-72321669 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028305
 protein coding gene Chr5:74461866-74528676 (-)
WSB/EiJ MGP_WSBEiJ_G0028827
 protein coding gene Chr5:75429423-75475718 (-)



Homology
more
  • Human Ortholog
    KDR, kinase insert domain receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KDR, kinase insert domain receptor
  • Synonyms
    CD309, FLK1, VEGFR, VEGFR2
  • Links
    NCBI Gene ID: 3791
    neXtProt AC: NX_P35968
    UniProt: P35968

  • Chr Location
    4q12; chr4:55078481-55125595 (-)  GRCh38
Human Diseases
more
  • Diseases
    15 with human KDR associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 13 alleles in 16 genetic backgrounds
    48 phenotypes from multigenic genotypes
    11 images
    235 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice die at early embryonic stages due to failure of blood vessel formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    203
  • GO References
    43
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2407
  • Tissues
    722
  • cDNA Data
    114
  • Literature Summary
    622
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062960 Ensembl Gene Model | MGI Sequence Detail 45632 C57BL/6J ±  kb
    transcript ENSMUST00000113516 Ensembl | MGI Sequence Detail 5924 Not Applicable  
    polypeptide ENSMUSP00000109144 Ensembl | MGI Sequence Detail 1345 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000002112 vascular endothelial growth factor receptor 2
      (term hierarchy)
    • EC
      2.7.10.1
    • InterPro Domains
      IPR013098 Immunoglobulin I-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003599 Immunoglobulin subtype
      IPR003598 Immunoglobulin subtype 2
      IPR042495 Platelet-derived growth factor receptor-like protein
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050122 Receptor Tyrosine Kinase
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
      IPR009136 Vascular endothelial growth factor receptor 2 (VEGFR2)
      IPR041348 VEGFR-2, transmembrane domain
    • GlyGen
      P35918 17 sites, 15 N-linked glycans (11 sites)
    Molecular
    Reagents
    less
    • All nucleic 205
      Genomic 8
      cDNA 123
      Primer pair 40
      Other 34

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11605, MGD-MRK-11606, MGD-MRK-9826, MGD-MRK-9828, MGI:5004964, MGI:95555
    References
    more
    • Summaries
      All 1000
      Developmental Gene Expression 622
      Gene Ontology 43
      Phenotypes 235
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:353090 Mertens RT, et al., A metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance. Immunity. 2024 Jun 19;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory