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Krt10 Gene Detail
Summary
  • Symbol
    Krt10
  • Name
    keratin 10
  • Synonyms
    cytokeratin 10, D130054E02Rik, K10, K1C1, keratin 10, Krt-1.10, Krt1-10, suprabasal cytokeratin 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:96685
    NCBI Gene: 16661
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:99276080-99280190 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 62.92 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96685
 protein coding gene Chr11:99276080-99288631 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019091
 protein coding gene Chr11:102049455-102053577 (-)
A/J MGP_AJ_G0019059
 protein coding gene Chr11:97753129-97757241 (-)
AKR/J MGP_AKRJ_G0019029
 protein coding gene Chr11:100787836-100792005 (-)
BALB/cJ MGP_BALBcJ_G0019033
 protein coding gene Chr11:98259020-98263127 (-)
C3H/HeJ MGP_C3HHeJ_G0018846
 protein coding gene Chr11:100937692-100941814 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019484
 protein coding gene Chr11:105187820-105191930 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017116
 protein coding gene Chr11:95315029-95319130 (-)
CAST/EiJ MGP_CASTEiJ_G0018401
 protein coding gene Chr11:101932934-101937077 (-)
CBA/J MGP_CBAJ_G0018817
 protein coding gene Chr11:109568855-109572963 (-)
DBA/2J MGP_DBA2J_G0018925
 protein coding gene Chr11:97319629-97323750 (-)
FVB/NJ MGP_FVBNJ_G0018914
 protein coding gene Chr11:96829819-96833941 (-)
LP/J MGP_LPJ_G0018995
 protein coding gene Chr11:102516579-102520701 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018941
 protein coding gene Chr11:109234360-109238481 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019524
 protein coding gene Chr11:101145311-101149415 (-)
PWK/PhJ MGP_PWKPhJ_G0018172
 protein coding gene Chr11:98392438-98396558 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017960
 protein coding gene Chr11:100902200-100906309 (-)
WSB/EiJ MGP_WSBEiJ_G0018449
 protein coding gene Chr11:101121626-101125735 (-)



Homology
more
  • Human Ortholog
    KRT10, keratin 10
  • Vertebrate Orthologs
    10
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT10, keratin 10
  • Synonyms
    BCIE, BIE, CK10, EHK, EHK2, EHK2A, EHK2B, IHL, K10, KPP
  • Links
    NCBI Gene ID: 3858
    neXtProt AC: NX_P13645
    UniProt: P13645

  • Chr Location
    17q21.2; chr17:40818117-40822614 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Krt10 mouse models; 2 with human KRT10 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 4 alleles in 5 genetic backgrounds
    9 phenotypes from multigenic genotypes
    4 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations may result in hyperkeratosis and blistering of the skin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1049
  • Tissues
    82
  • cDNA Data
    133
  • Literature Summary
    215
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019761 Ensembl Gene Model | MGI Sequence Detail 4111 C57BL/6J ±  kb
    transcript ENSMUST00000103131 Ensembl | MGI Sequence Detail 2094 Not Applicable  
    polypeptide ENSMUSP00000099420 Ensembl | MGI Sequence Detail 561 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 148
      Genomic 5
      cDNA 137
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11630, MGD-MRK-11640, MGI:2441944
    References
    more
    • Summaries
      All 298
      Developmental Gene Expression 215
      Diseases 1
      Gene Ontology 14
      Phenotypes 28
    • Earliest
      J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
    • Latest
      J:352165 Lin Y, et al., Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development. Dev Dyn. 2024 Jul;253(7):635-647
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory