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Krt16 Gene Detail
Summary
  • Symbol
    Krt16
  • Name
    keratin 16
  • Synonyms
    K16, Krt1-16
  • Feature Type
    protein coding gene
  • IDs
    MGI:96690
    NCBI Gene: 16666
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100136917-100139728 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    228 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96690
 protein coding gene Chr11:100136917-100139728 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019146
 protein coding gene Chr11:103001324-103006439 (-)
A/J MGP_AJ_G0019114
 protein coding gene Chr11:98675760-98679451 (-)
AKR/J MGP_AKRJ_G0019083
 protein coding gene Chr11:101720480-101726183 (-)
BALB/cJ MGP_BALBcJ_G0019088
 protein coding gene Chr11:99168107-99172152 (-)
C3H/HeJ MGP_C3HHeJ_G0018897
 protein coding gene Chr11:101911743-101918880 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019537
 protein coding gene Chr11:106148103-106155359 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017164
 protein coding gene Chr11:96107644-96112495 (-)
CAST/EiJ MGP_CASTEiJ_G0018451
 protein coding gene Chr11:102866066-102881508 (-)
CBA/J MGP_CBAJ_G0018866
 protein coding gene Chr11:110603763-110608881 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0018968
 protein coding gene Chr11:97744730-97747310 (-)
LP/J MGP_LPJ_G0019047
 protein coding gene Chr11:103536294-103542033 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018999
 protein coding gene Chr11:110224138-110237684 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019575
 protein coding gene Chr11:102077434-102079653 (-)
PWK/PhJ MGP_PWKPhJ_G0018214
 protein coding gene Chr11:99238283-99254047 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018006
 protein coding gene Chr11:101778647-101784916 (-)
WSB/EiJ MGP_WSBEiJ_G0018500
 protein coding gene Chr11:102059928-102062667 (-)



Homology
more
  • Human Ortholog
    KRT16, keratin 16
  • Vertebrate Orthologs
    13
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT16, keratin 16
  • Synonyms
    CK16, FNEPPK, K16, K1CP, KRT16A, NEPPK, PC1
  • Links
    NCBI Gene ID: 3868
    neXtProt AC: NX_P08779
    UniProt: P08779

  • Chr Location
    17q21.2; chr17:41609778-41615899 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Krt16 mouse models; 3 with human KRT16 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial neonatal and postnatal lethality, decreased body weight, abnormal tongue epithelium and hyperkertotic calluses in areas of physical pressure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    878
  • Tissues
    25
  • cDNA Data
    22
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16666 NCBI Gene Model | MGI Sequence Detail 2812 C57BL/6J ±  kb
    transcript NM_001313958 RefSeq | MGI Sequence Detail 1628 C57BL/6  
    polypeptide Q9Z2K1 UniProt | EBI | MGI Sequence Detail 469 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 22
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11645, MGI:2144125
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
    • Latest
      J:289179 Steen K, et al., A role for keratins in supporting mitochondrial organization and function in skin keratinocytes. Mol Biol Cell. 2020 May 15;31(11):1103-1111
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory