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Krt18 Gene Detail
Summary
  • Symbol
    Krt18
  • Name
    keratin 18
  • Synonyms
    CK18, Endo B, K18, Krt1-18
  • Feature Type
    protein coding gene
  • IDs
    MGI:96692
    NCBI Gene: 16668
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:101936651-101940461 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 57.22 cM, cytoband F3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96692
 protein coding gene Chr15:101936615-101940462 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022396
 protein coding gene Chr15:104165250-104170971 (+)
A/J MGP_AJ_G0022358
 protein coding gene Chr15:100087498-100091304 (+)
AKR/J MGP_AKRJ_G0022333
 protein coding gene Chr15:103115427-103120885 (+)
BALB/cJ MGP_BALBcJ_G0022362
 protein coding gene Chr15:100129269-100134465 (+)
C3H/HeJ MGP_C3HHeJ_G0022129
 protein coding gene Chr15:103182346-103186152 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022811
 protein coding gene Chr15:108036611-108048166 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020334
 protein coding gene Chr15:95865280-95869041 (+)
CAST/EiJ MGP_CASTEiJ_G0021655
 protein coding gene Chr15:104041877-104045671 (+)
CBA/J MGP_CBAJ_G0022098
 protein coding gene Chr15:111818264-111822070 (+)
DBA/2J MGP_DBA2J_G0022229
 protein coding gene Chr15:99370363-99374475 (+)
FVB/NJ MGP_FVBNJ_G0022205
 protein coding gene Chr15:98430120-98433885 (+)
LP/J MGP_LPJ_G0022298
 protein coding gene Chr15:104327739-104333426 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022227
 protein coding gene Chr15:115424328-115429408 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022823
 protein coding gene Chr15:103131842-103137672 (+)
PWK/PhJ MGP_PWKPhJ_G0021395
 protein coding gene Chr15:99521019-99524811 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021227
 protein coding gene Chr15:102975189-102978967 (+)
WSB/EiJ MGP_WSBEiJ_G0021705
 protein coding gene Chr15:103763021-103766821 (+)



Homology
more
  • Human Ortholog
    KRT18, keratin 18
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT18, keratin 18
  • Synonyms
    CK-18, CYK18, K18
  • Links
    NCBI Gene ID: 3875
    neXtProt AC: NX_P05783
    UniProt: P05783

  • Chr Location
    12q13.13; chr12:52948855-52952906 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Krt18 mouse models; 1 with human KRT18 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are viable, fertile, and live normal life spans. They do, however, develop hepatomegaly by 18 months of age. Aged mice develop liver lesions resembling steatohepatitis and eventually liver tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1277
  • Tissues
    248
  • cDNA Data
    490
  • Literature Summary
    133
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16668 NCBI Gene Model | MGI Sequence Detail 3811 C57BL/6J ±  kb
    transcript NM_010664 RefSeq | MGI Sequence Detail 1400 ZRU/MplStud  
    polypeptide P05784 UniProt | EBI | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000009458 keratin, type I cytoskeletal 18
      (term hierarchy)
    • InterPro Domains
      IPR018039 Intermediate filament protein, conserved site
      IPR039008 Intermediate filament, rod domain
      IPR002957 Keratin, type I
    • GlyGen
      P05784 6 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 509
      Genomic 6
      cDNA 493
      Primer pair 9
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11647
    References
    more
    • Summaries
      All 220
      Developmental Gene Expression 133
      Diseases 2
      Gene Ontology 12
      Phenotypes 43
    • Earliest
      J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
    • Latest
      J:352089 Grammer C, et al., Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development. iScience. 2024 Jul 19;27(7):110258
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory