About   Help   FAQ
Lhcgr Gene Detail
Summary
  • Symbol
    Lhcgr
  • Name
    luteinizing hormone/choriogonadotropin receptor
  • Synonyms
    Gpcr19-rs1, Lhr, LH-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:96783
    NCBI Gene: 16867
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:89023909-89099418 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 58.35 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2477 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96783
 protein coding gene Chr17:89023812-89099487 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024113
 protein coding gene Chr17:92235201-92289259 (-)
A/J MGP_AJ_G0024073
 protein coding gene Chr17:89265056-89316290 (-)
AKR/J MGP_AKRJ_G0024042
 protein coding gene Chr17:90755925-90806891 (-)
BALB/cJ MGP_BALBcJ_G0024074
 protein coding gene Chr17:89087405-89138616 (-)
C3H/HeJ MGP_C3HHeJ_G0023839
 protein coding gene Chr17:91653620-91705824 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024519
 protein coding gene Chr17:95462918-95517344 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021957
 protein coding gene Chr17:84323060-84372134 (-)
CAST/EiJ MGP_CASTEiJ_G0023318
 protein coding gene Chr17:92517660-92572901 (-)
CBA/J MGP_CBAJ_G0023812
 protein coding gene Chr17:99482407-99537955 (-)
DBA/2J MGP_DBA2J_G0023941
 protein coding gene Chr17:87647236-87697601 (-)
FVB/NJ MGP_FVBNJ_G0023907
 protein coding gene Chr17:87185446-87242060 (-)
LP/J MGP_LPJ_G0024025
 protein coding gene Chr17:93034143-93084019 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023935
 protein coding gene Chr17:99253993-99304526 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024564
 protein coding gene Chr17:91306975-91361613 (-)
PWK/PhJ MGP_PWKPhJ_G0023063
 protein coding gene Chr17:87338368-87392130 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022874
 protein coding gene Chr17:88034512-88086030 (-)
WSB/EiJ MGP_WSBEiJ_G0023384
 protein coding gene Chr17:92169384-92221024 (-)



Homology
more
  • Human Ortholog
    LHCGR, luteinizing hormone/choriogonadotropin receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LHCGR, luteinizing hormone/choriogonadotropin receptor
  • Synonyms
    HHG, LCGR, LGR2, LH/CG-R, LH/CGR, LHR, LHRHR, LSH-R, ULG5
  • Links
    NCBI Gene ID: 3973
    neXtProt AC: NX_P22888
    UniProt: P22888

  • Chr Location
    2p16.3; chr2:48686774-48755730 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human LHCGR associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    103 phenotypes from 4 alleles in 4 genetic backgrounds
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are infertile and have abnormal hormone levels. Males have undescended testes, immature external and accessory sex organs and blocked spermatogenesis. Females have small ovaries and uteri, immature follicles and do not cycle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    12
  • cDNA Data
    11
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024107 Ensembl Gene Model | MGI Sequence Detail 75510 C57BL/6J ±  kb
    transcript ENSMUST00000024916 Ensembl | MGI Sequence Detail 6828 Not Applicable  
    polypeptide ENSMUSP00000024916 Ensembl | MGI Sequence Detail 700 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 4
      cDNA 12
      Primer pair 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11803, MGD-MRK-11804, MGD-MRK-16386, MGI:96784
    References
    more
    • Summaries
      All 116
      Developmental Gene Expression 21
      Gene Ontology 9
      Phenotypes 42
    • Earliest
      J:32180 McFarland KC, et al., Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. Science. 1989 Aug 4;245(4917):494-9
    • Latest
      J:358366 Kanatsu-Shinohara M, et al., Sendai virus-mediated RNA delivery restores fertility to congenital and chemotherapy-induced infertile female mice. PNAS Nexus. 2024 Sep;3(9):pgae375
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory