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Lif Gene Detail
Summary
  • Symbol
    Lif
  • Name
    leukemia inhibitory factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:96787
    NCBI Gene: 16878
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:4207587-4222514 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 2.94 cM, cytoband A1-A2
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    332 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96787
 protein coding gene Chr11:4207557-4222514 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017981
 protein coding gene Chr11:1193323-1220046 (+)
A/J MGP_AJ_G0017954
 protein coding gene Chr11:1202123-1217346 (+)
AKR/J MGP_AKRJ_G0017918
 protein coding gene Chr11:1257095-1272357 (+)
BALB/cJ MGP_BALBcJ_G0017922
 protein coding gene Chr11:1173462-1188937 (+)
C3H/HeJ MGP_C3HHeJ_G0017735
 protein coding gene Chr11:1156755-1171733 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018375
 protein coding gene Chr11:1273900-1291663 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016033
 protein coding gene Chr11:1082086-1097774 (+)
CAST/EiJ MGP_CASTEiJ_G0017297
 protein coding gene Chr11:1119976-1137762 (+)
CBA/J MGP_CBAJ_G0017710
 protein coding gene Chr11:1519721-1535714 (+)
DBA/2J MGP_DBA2J_G0017821
 protein coding gene Chr11:1107465-1122529 (+)
FVB/NJ MGP_FVBNJ_G0017812
 protein coding gene Chr11:1139940-1154915 (+)
LP/J MGP_LPJ_G0017891
 protein coding gene Chr11:1298668-1313553 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017838
 protein coding gene Chr11:1184020-1211104 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018414
 protein coding gene Chr11:1267918-1283208 (+)
PWK/PhJ MGP_PWKPhJ_G0017078
 protein coding gene Chr11:1109892-1125406 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016874
 protein coding gene Chr11:1229582-1246654 (+)
WSB/EiJ MGP_WSBEiJ_G0017351
 protein coding gene Chr11:1130825-1146101 (+)



Homology
more
  • Human Ortholog
    LIF, LIF interleukin 6 family cytokine
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIF, LIF interleukin 6 family cytokine
  • Synonyms
    CDF, DIA, HILDA, MLPLI
  • Links
    NCBI Gene ID: 3976
    neXtProt AC: NX_P15018
    UniProt: P15018

  • Chr Location
    22q12.2; chr22:30240453-30246759 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    68 phenotypes from 3 alleles in 9 genetic backgrounds
    38 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations have reduced numbers of stem cells in spleen and bone marrow, enhanced inflammatory responses, impaired sensory neuron regrowth, and uterine insufficiency. Heterozygotes show intermediate numbers of stem cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    85
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    943
  • Tissues
    141
  • cDNA Data
    21
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16878 NCBI Gene Model | MGI Sequence Detail 14928 C57BL/6J ±  kb
    transcript NM_001039537 RefSeq | MGI Sequence Detail 4221 ZRU/MplStud  
    polypeptide P09056 UniProt | EBI | MGI Sequence Detail 203 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 7
      cDNA 24
      Primer pair 10
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11807
    References
    more
    • Summaries
      All 251
      Developmental Gene Expression 46
      Gene Ontology 20
      Phenotypes 73
    • Earliest
      J:9088 Gearing DP, et al., Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF). EMBO J. 1987 Dec 20;6(13):3995-4002
    • Latest
      J:350445 Sakurai J, et al., Effects of blastocyst elongation and implantation chamber formation on the alignment of the embryonic axis and uterine axis in mice. Front Cell Dev Biol. 2024;12:1421222
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory