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Lox Gene Detail
Summary
  • Symbol
    Lox
  • Name
    lysyl oxidase
  • Synonyms
    ras recision gene (rrg), TSC-160
  • Feature Type
    protein coding gene
  • IDs
    MGI:96817
    NCBI Gene: 16948
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:52649139-52662939 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 28.22 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    391 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96817
 protein coding gene Chr18:52649132-52662939 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024428
 protein coding gene Chr18:51638733-51653070 (-)
A/J MGP_AJ_G0024394
 protein coding gene Chr18:49648230-49661689 (-)
AKR/J MGP_AKRJ_G0024364
 protein coding gene Chr18:51040840-51054769 (-)
BALB/cJ MGP_BALBcJ_G0024394
 protein coding gene Chr18:49815911-49842815 (-)
C3H/HeJ MGP_C3HHeJ_G0024161
 protein coding gene Chr18:51170277-51185918 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024840
 protein coding gene Chr18:53381212-53398983 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022272
 protein coding gene Chr18:49452370-49465856 (-)
CAST/EiJ MGP_CASTEiJ_G0023635
 protein coding gene Chr18:51119195-51147601 (-)
CBA/J MGP_CBAJ_G0024131
 protein coding gene Chr18:54943940-54963912 (-)
DBA/2J MGP_DBA2J_G0024261
 protein coding gene Chr18:49354662-49369171 (-)
FVB/NJ MGP_FVBNJ_G0024228
 protein coding gene Chr18:48789128-48802786 (-)
LP/J MGP_LPJ_G0024346
 protein coding gene Chr18:51665231-51680018 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024258
 protein coding gene Chr18:56706334-56721188 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024887
 protein coding gene Chr18:51051490-51066469 (-)
PWK/PhJ MGP_PWKPhJ_G0023379
 protein coding gene Chr18:49373671-49390735 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023185
 protein coding gene Chr18:51221726-51256588 (-)
WSB/EiJ MGP_WSBEiJ_G0023698
 protein coding gene Chr18:50961232-50977540 (-)



Homology
more
  • Human Ortholog
    LOX, lysyl oxidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LOX, lysyl oxidase
  • Synonyms
    AAT10
  • Links
    NCBI Gene ID: 4015
    neXtProt AC: NX_P28300
    UniProt: P28300

  • Chr Location
    5q23.1; chr5:122063195-122078413 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Lox mouse models; 5 with human LOX associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    52 phenotypes from 5 alleles in 5 genetic backgrounds
    14 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to altered arterial wall structure, aortic aneurysms, cardiovascular dysfunction, diaphragmatic hernia, and perinatal death. Abnormal development of the respiratory system, and elastic and collagen fiber abnormalities in the lung and skin are also observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    138
  • cDNA Data
    36
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024529 Ensembl Gene Model | MGI Sequence Detail 13801 C57BL/6J ±  kb
    transcript ENSMUST00000025409 Ensembl | MGI Sequence Detail 4741 Not Applicable  
    polypeptide ENSMUSP00000025409 Ensembl | MGI Sequence Detail 411 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 9
      cDNA 38
      Primer pair 9

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11866, MGI:2147282
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 31
      Diseases 2
      Gene Ontology 31
      Phenotypes 27
    • Earliest
      J:5777 Rowe DW, et al., Decreased lysyl oxidase activity in the aneurysm-prone, mottled mouse. J Biol Chem. 1977 Feb 10;252(3):939-42
    • Latest
      J:358805 Stoyell-Conti FF, et al., Gene inactivation of lysyl oxidase in smooth muscle cells reduces atherosclerosis burden and plaque calcification in hyperlipidemic mice. Atherosclerosis. 2024 Oct;397:118582
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory