Lpl MGI Mouse Gene Detail - MGI:96820

Symbol

Lpl
Name

lipoprotein lipase
Synonyms

O 1-4-5

Feature Type

protein coding gene
IDs

MGI:96820
NCBI Gene: 16956
Alliance

gene page
Transcription Start Sites

53 TSS

Sequence Map

Chr8:69333207-69359584 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 33.88 cM
Mapping Data

32 experiments

SNPs within 2kb

728 from dbSNP Build 142
Strain Annotations

18
RFLP

10

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96820	protein coding gene	Chr8:69333143-69360100 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033663	protein coding gene	Chr8:69010062-69039365 (+)
A/J	MGP_AJ_G0033645	protein coding gene	Chr8:66228223-66254877 (+)
AKR/J	MGP_AKRJ_G0033570	protein coding gene	Chr8:68034099-68063983 (+)
BALB/cJ	MGP_BALBcJ_G0033641	protein coding gene	Chr8:66443605-66470796 (+)
C3H/HeJ	MGP_C3HHeJ_G0033351	protein coding gene	Chr8:68763960-68791512 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034158	protein coding gene	Chr8:71612060-71641079 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031105	protein coding gene	Chr8:61108965-61135418 (+)
CAST/EiJ	MGP_CASTEiJ_G0032676	protein coding gene	Chr8:68204614-68232768 (+)
CBA/J	MGP_CBAJ_G0033329	protein coding gene	Chr8:74299186-74329225 (+)
DBA/2J	MGP_DBA2J_G0033483	protein coding gene	Chr8:65949366-65976192 (+)
FVB/NJ	MGP_FVBNJ_G0033424	protein coding gene	Chr8:65101947-65130548 (+)
LP/J	MGP_LPJ_G0033571	protein coding gene	Chr8:69110605-69137386 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033468	protein coding gene	Chr8:76964537-76994196 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034176	protein coding gene	Chr8:68313379-68344731 (+)
PWK/PhJ	MGP_PWKPhJ_G0032385	protein coding gene	Chr8:65192192-65220188 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032221	protein coding gene	Chr8:67253940-67291716 (+)
WSB/EiJ	MGP_WSBEiJ_G0032793	protein coding gene	Chr8:68681882-68711559 (+)

Human Ortholog

LPL, lipoprotein lipase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LPL, lipoprotein lipase
Synonyms

HDLCQ11, LIPD
Links

HGNC:6677

NCBI Gene ID: 4023

neXtProt AC: NX_P06858

UniProt: P06858
Chr Location

8p21.3; chr8:19901717-19967259 (+) GRCh38

MGI Vertebrate Homology

Lpl stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LPL
Protein SuperFamily

Lipoprotein_lipase_LIPH
Gene Tree

Lpl

Diseases

1 with Lpl mouse models; 9 with human LPL associations

Human Disease

Mouse Models

familial lipoprotein lipase deficiency

IDs

View 4 models

Alzheimer's disease

IDs

coronary artery disease

IDs

familial combined hyperlipidemia

IDs

View 1 model

familial hyperlipidemia

IDs

hypertension

IDs

muscular disease

IDs

myocardial infarction

IDs

type 2 diabetes mellitus

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

4 with disease annotations

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Phenotype Summary

38 phenotypes from 3 alleles in 5 genetic backgrounds
21 phenotypes from multigenic genotypes
6 images
84 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

5
Targeted

6
Genomic Mutations

1 involving Lpl
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations become cyanotic and die within 2 days of birth due to chylomicron engorgement of capillaries. Mutants show hypertriglyceridemia and reduced fat stores. Heterozygotes show 1.5-2-fold elevated triglyceride levels.

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All GO Annotations

81
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1273
Tissues

176
cDNA Data

376
Literature Summary

42

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA LPL

Xenbase lpl

ZFIN lpla

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All Sequences

137
RefSeq

2
UniProt

19
CCDS

CCDS40357.1

Ensembl

ENSMUSG00000015568 (Evidence)
NCBI Gene

16956

			Length	Strain/Species	Flank
genomic	16956	NCBI Gene Model \| MGI Sequence Detail	26378	C57BL/6J	± kb
transcript	NM_008509	RefSeq \| MGI Sequence Detail	4049	ZRU/MplStud
polypeptide	P11152	UniProt \| EBI \| MGI Sequence Detail	474	Not Applicable

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UniProt

19 Sequences
Protein Ontology

PR:000009897 lipoprotein lipase

(term hierarchy)
EC

3.1.1.32, 3.1.1.34
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR013818 Lipase

IPR016272 Lipase, LIPH-type

IPR033906 Lipase, N-terminal

IPR002330 Lipoprotein lipase

IPR001024 PLAT/LH2 domain

IPR036392 PLAT/LH2 domain superfamily

IPR000734 Triacylglycerol lipase family
GlyGen

P11152 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 396

Genomic 6

cDNA 382

Primer pair 6

Other 2

Microarray probesets 5

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MGD-MRK-11871

Summaries

All 243

Developmental Gene Expression 42

Diseases 4

Gene Ontology 17

Phenotypes 84
Earliest

J:8759 Kirchgessner TG, et al., The sequence of cDNA encoding lipoprotein lipase. A member of a lipase gene family. J Biol Chem. 1987 Jun 25;262(18):8463-6
Latest

J:353478 Farley A, et al., Activation of VGLL4 Suppresses Cardiomyocyte Maturational Hypertrophic Growth. Cells. 2024 Aug 13;13(16)

TSS for Lpl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77601	Chr8:69333200-69333216 (+)	1 bp
Tssr77602	Chr8:69333283-69333294 (+)	82 bp
Tssr77603	Chr8:69333302-69333324 (+)	106 bp
Tssr77604	Chr8:69333366-69333369 (+)	161 bp
Tssr77605	Chr8:69333375-69333382 (+)	172 bp
Tssr77606	Chr8:69336999-69337002 (+)	3,794 bp
Tssr77607	Chr8:69337065-69337076 (+)	3,864 bp
Tssr77608	Chr8:69337086-69337103 (+)	3,888 bp
Tssr77609	Chr8:69337121-69337145 (+)	3,926 bp
Tssr77610	Chr8:69337192-69337213 (+)	3,996 bp
Tssr77611	Chr8:69339568-69339578 (+)	6,366 bp
Tssr77612	Chr8:69339593-69339615 (+)	6,397 bp
Tssr77613	Chr8:69345241-69345378 (+)	12,103 bp
Tssr77614	Chr8:69347270-69347368 (+)	14,112 bp
Tssr77615	Chr8:69348311-69348378 (+)	15,138 bp
Tssr77616	Chr8:69348409-69348422 (+)	15,209 bp
Tssr77617	Chr8:69348449-69348495 (+)	15,265 bp
Tssr77618	Chr8:69348496-69348505 (+)	15,294 bp
Tssr77619	Chr8:69349240-69349258 (+)	16,042 bp
Tssr77620	Chr8:69349259-69349303 (+)	16,074 bp
Tssr77621	Chr8:69349337-69349340 (+)	16,132 bp
Tssr77622	Chr8:69349342-69349353 (+)	16,141 bp
Tssr77623	Chr8:69349385-69349393 (+)	16,182 bp
Tssr77624	Chr8:69349409-69349426 (+)	16,211 bp
Tssr77625	Chr8:69349431-69349443 (+)	16,230 bp
Tssr77626	Chr8:69349446-69349456 (+)	16,244 bp
Tssr77627	Chr8:69352127-69352173 (+)	18,943 bp
Tssr77628	Chr8:69353797-69353871 (+)	20,627 bp
Tssr77629	Chr8:69353877-69353931 (+)	20,697 bp
Tssr77630	Chr8:69354948-69354970 (+)	21,752 bp
Tssr77631	Chr8:69354973-69354986 (+)	21,773 bp
Tssr77632	Chr8:69357151-69357166 (+)	23,952 bp
Tssr77633	Chr8:69357268-69357288 (+)	24,071 bp
Tssr77634	Chr8:69357343-69357362 (+)	24,146 bp
Tssr77635	Chr8:69357484-69357506 (+)	24,288 bp
Tssr77636	Chr8:69357518-69357532 (+)	24,318 bp
Tssr77637	Chr8:69357533-69357554 (+)	24,337 bp
Tssr77638	Chr8:69357635-69357650 (+)	24,436 bp
Tssr77639	Chr8:69357716-69357791 (+)	24,547 bp
Tssr77640	Chr8:69357792-69357814 (+)	24,596 bp
Tssr77641	Chr8:69358463-69358481 (+)	25,265 bp
Tssr77642	Chr8:69358488-69358499 (+)	25,287 bp
Tssr77643	Chr8:69358623-69358630 (+)	25,420 bp
Tssr77644	Chr8:69358675-69358686 (+)	25,474 bp
Tssr77645	Chr8:69358728-69358739 (+)	25,527 bp
Tssr77646	Chr8:69358741-69358752 (+)	25,540 bp
Tssr77647	Chr8:69358798-69358809 (+)	25,597 bp
Tssr77648	Chr8:69358840-69358849 (+)	25,638 bp
Tssr77649	Chr8:69358855-69358862 (+)	25,652 bp
Tssr77650	Chr8:69358976-69358983 (+)	25,773 bp
Tssr77651	Chr8:69359010-69359018 (+)	25,807 bp
Tssr77652	Chr8:69359111-69359122 (+)	25,910 bp
Tssr77653	Chr8:69359152-69359161 (+)	25,950 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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