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Lrp1 Gene Detail
Summary
  • Symbol
    Lrp1
  • Name
    low density lipoprotein receptor-related protein 1
  • Synonyms
    A2mr, b2b1554Clo, CD91
  • Feature Type
    protein coding gene
  • IDs
    MGI:96828
    NCBI Gene: 16971
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127374030-127457017 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.52 cM, cytoband B2-D1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1968 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96828
 protein coding gene Chr10:127374026-127457158 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017827
 protein coding gene Chr10:131159698-131242448 (-)
A/J MGP_AJ_G0017802
 protein coding gene Chr10:125906601-125988974 (-)
AKR/J MGP_AKRJ_G0017765
 protein coding gene Chr10:129622697-129707654 (-)
BALB/cJ MGP_BALBcJ_G0017766
 protein coding gene Chr10:126311060-126393569 (-)
C3H/HeJ MGP_C3HHeJ_G0017590
 protein coding gene Chr10:129774259-129860842 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018221
 protein coding gene Chr10:135604066-135691784 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015901
 protein coding gene Chr10:119892673-119977329 (-)
CAST/EiJ MGP_CASTEiJ_G0017150
 protein coding gene Chr10:130434784-130519728 (-)
CBA/J MGP_CBAJ_G0017559
 protein coding gene Chr10:141068049-141163271 (-)
DBA/2J MGP_DBA2J_G0017665
 protein coding gene Chr10:124982168-125066891 (-)
FVB/NJ MGP_FVBNJ_G0017660
 protein coding gene Chr10:123923632-124008068 (-)
LP/J MGP_LPJ_G0017739
 protein coding gene Chr10:131731109-131818469 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017688
 protein coding gene Chr10:143763306-143847159 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018261
 protein coding gene Chr10:129688005-129779758 (-)
PWK/PhJ MGP_PWKPhJ_G0016935
 protein coding gene Chr10:125187626-125271997 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016727
 protein coding gene Chr10:128728877-128808395 (-)
WSB/EiJ MGP_WSBEiJ_G0017211
 protein coding gene Chr10:129915183-130002844 (-)



Homology
more
  • Human Ortholog
    LRP1, LDL receptor related protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRP1, LDL receptor related protein 1
  • Synonyms
    A2MR, APOER, APR, CD91, DDH3, IGFBP-3R, IGFBP3R, IGFBP3R1, KPA, LRP, LRP1A, TGFBR5
  • Links
    NCBI Gene ID: 4035
    neXtProt AC: NX_Q07954
    UniProt: Q07954

  • Chr Location
    12q13.3; chr12:57128483-57213361 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with Lrp1 mouse models; 4 with human LRP1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    113 phenotypes from 10 alleles in 10 genetic backgrounds
    34 phenotypes from multigenic genotypes
    20 images
    147 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit lethality during late organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    134
  • GO References
    36
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1045
  • Tissues
    125
  • cDNA Data
    318
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040249 Ensembl Gene Model | MGI Sequence Detail 82988 C57BL/6J ±  kb
    transcript ENSMUST00000049149 Ensembl | MGI Sequence Detail 14888 Not Applicable  
    polypeptide ENSMUSP00000044004 Ensembl | MGI Sequence Detail 4545 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000002058 low-density lipoprotein receptor-related protein 1
      (term hierarchy)
    • InterPro Domains
      IPR026823 Complement Clr-like EGF domain
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR013032 EGF-like, conserved site
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR000033 LDLR class B repeat
      IPR036055 LDL receptor-like superfamily
      IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR050685 Low-density lipoprotein receptor
      IPR051221 Low-density lipoprotein receptor-related
      IPR049883 NOTCH1 EGF-like calcium-binding domain
      IPR050906 Notch signaling pathway
      IPR032485 Prolow-density lipoprotein receptor-related protein 1-like, beta-propeller domain
      IPR011042 Six-bladed beta-propeller, TolB-like
    • GlyGen
      Q91ZX7 52 sites, 53 N-linked glycans (37 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 329
      Genomic 7
      cDNA 320
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1007, MGD-MRK-11886, MGI:2143570, MGI:5437071
    References
    more
    • Summaries
      All 293
      Developmental Gene Expression 30
      Diseases 4
      Gene Ontology 36
      Phenotypes 147
    • Earliest
      J:30078 Herz J, et al., Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J. 1988 Dec 20;7(13):4119-27
    • Latest
      J:358232 Nishimura S, et al., LRP1-deficient leptin receptor-positive cells in periodontal ligament tissue reduce alveolar bone mass by inhibiting bone formation. Arch Oral Biol. 2024 Feb;158:105853
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory