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Ltf Gene Detail
Summary
  • Symbol
    Ltf
  • Name
    lactotransferrin
  • Synonyms
    lactoferrin, Lf
  • Feature Type
    protein coding gene
  • IDs
    MGI:96837
    NCBI Gene: 17002
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:110848360-110871834 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 60.79 cM, cytoband F
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    901 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96837
 protein coding gene Chr9:110848339-110871835 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035368
 protein coding gene Chr9:113216147-113243304 (+)
A/J MGP_AJ_G0035349
 protein coding gene Chr9:109088089-109111521 (+)
AKR/J MGP_AKRJ_G0035280
 protein coding gene Chr9:111808128-111831440 (+)
BALB/cJ MGP_BALBcJ_G0035344
 protein coding gene Chr9:108838627-108864194 (+)
C3H/HeJ MGP_C3HHeJ_G0035052
 protein coding gene Chr9:112307055-112333008 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035866
 protein coding gene Chr9:116348335-116373309 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032752
 protein coding gene Chr9:106299323-106322873 (+)
CAST/EiJ MGP_CASTEiJ_G0034358
 protein coding gene Chr9:112109616-112136021 (+)
CBA/J MGP_CBAJ_G0035019
 protein coding gene Chr9:120620277-120654517 (+)
DBA/2J MGP_DBA2J_G0035178
 protein coding gene Chr9:108542600-108566197 (+)
FVB/NJ MGP_FVBNJ_G0035125
 protein coding gene Chr9:107387324-107412348 (+)
LP/J MGP_LPJ_G0035257
 protein coding gene Chr9:113507567-113531708 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035165
 protein coding gene Chr9:121941677-121968672 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035886
 protein coding gene Chr9:112152999-112180647 (+)
PWK/PhJ MGP_PWKPhJ_G0034065
 protein coding gene Chr9:108788778-108813368 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033900
 protein coding gene Chr9:112239801-112268065 (+)
WSB/EiJ MGP_WSBEiJ_G0034479
 protein coding gene Chr9:112021566-112046369 (+)



Homology
more
  • Human Ortholog
    LTF, lactotransferrin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LTF, lactotransferrin
  • Synonyms
    GIG12, HEL110, HLF2, LF
  • Links
    NCBI Gene ID: 4057
    neXtProt AC: NX_P02788
    UniProt: P02788

  • Chr Location
    3p21.31; chr3:46435645-46485234 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human LTF associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    2 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, fertile, and grossly normal and exhibit only minor alterations in iron homeostasis. Mice homozygous for a different knock-out allele show increased susceptibility to inflammation-induced colorectal dysplasia along with increased cell proliferation and decreased apoptosis in colonic tissues.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    81
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    52
  • cDNA Data
    1666
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17002 NCBI Gene Model | MGI Sequence Detail 23475 C57BL/6J ±  kb
    transcript NM_008522 RefSeq | MGI Sequence Detail 2742 ZRU/MplStud  
    polypeptide P08071 UniProt | EBI | MGI Sequence Detail 707 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1684
      Genomic 11
      cDNA 1667
      Primer pair 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11899
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 21
      Gene Ontology 9
      Phenotypes 38
    • Earliest
      J:8905 Teng CT, et al., Assignment of the lactotransferrin gene to human chromosome 3 and to mouse chromosome 9. Somat Cell Mol Genet. 1987 Nov;13(6):689-93
    • Latest
      J:338821 Li R, et al., TRIM28 modulates nuclear receptor signaling to regulate uterine function. Nat Commun. 2023 Aug 1;14(1):4605
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory