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Mak Gene Detail
Summary
  • Symbol
    Mak
  • Name
    male germ cell-associated kinase
  • Synonyms
    A930010O05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:96913
    NCBI Gene: 17152
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:41178484-41233182 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 20.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1499 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96913
 protein coding gene Chr13:41178483-41233182 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020483
 protein coding gene Chr13:39507284-39559761 (-)
A/J MGP_AJ_G0020437
 protein coding gene Chr13:38182644-38237552 (-)
AKR/J MGP_AKRJ_G0020415
 protein coding gene Chr13:39225825-39278345 (-)
BALB/cJ MGP_BALBcJ_G0020433
 protein coding gene Chr13:38372142-38421149 (-)
C3H/HeJ MGP_C3HHeJ_G0020232
 protein coding gene Chr13:39108488-39160501 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020866
 protein coding gene Chr13:40760470-40816277 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018453
 protein coding gene Chr13:36322923-36369641 (-)
CAST/EiJ MGP_CASTEiJ_G0019747
 protein coding gene Chr13:38880191-38932779 (-)
CBA/J MGP_CBAJ_G0020193
 protein coding gene Chr13:42511045-42563878 (-)
DBA/2J MGP_DBA2J_G0020315
 protein coding gene Chr13:37762273-37811526 (-)
FVB/NJ MGP_FVBNJ_G0020294
 protein coding gene Chr13:37257587-37306762 (-)
LP/J MGP_LPJ_G0020390
 protein coding gene Chr13:39747908-39799760 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020323
 protein coding gene Chr13:42479967-42528996 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020909
 protein coding gene Chr13:38876413-38928916 (-)
PWK/PhJ MGP_PWKPhJ_G0019502
 protein coding gene Chr13:37824418-37885652 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019332
 protein coding gene Chr13:37483252-37535280 (-)
WSB/EiJ MGP_WSBEiJ_G0019809
 protein coding gene Chr13:39176607-39226394 (-)



Homology
more
  • Human Ortholog
    MAK, male germ cell associated kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAK, male germ cell associated kinase
  • Synonyms
    RP62
  • Links
    NCBI Gene ID: 4117
    neXtProt AC: NX_P20794
    UniProt: P20794

  • Chr Location
    6p24.2; chr6:10762723-10838553 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MAK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males homozygous for a targeted null mutation exhibit slight reductions in litter size and sperm motility in vitro.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    22
  • cDNA Data
    30
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021363 Ensembl Gene Model | MGI Sequence Detail 54699 C57BL/6J ±  kb
transcript ENSMUST00000225084 Ensembl | MGI Sequence Detail 3573 Not Applicable  
polypeptide ENSMUSP00000152946 Ensembl | MGI Sequence Detail 646 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    Genomic 1
    cDNA 31
    Other 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12106, MGI:2444483
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:347611 Varner LR, et al., The deubiquitinase Otud7b suppresses cone photoreceptor degeneration in mouse models of retinal degenerative diseases. iScience. 2024 Apr 19;27(4):109380
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory