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Mas1 Gene Detail
Summary
  • Symbol
    Mas1
  • Name
    MAS1 oncogene
  • Synonyms
    Mas-1, MasR, Mas receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:96918
    NCBI Gene: 17171
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:13059966-13087030 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 8.69 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    309 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96918
 protein coding gene Chr17:13056981-13087037 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023150
 protein coding gene Chr17:10505219-10536889 (-)
A/J MGP_AJ_G0023118
 protein coding gene Chr17:10339227-10366101 (-)
AKR/J MGP_AKRJ_G0023082
 protein coding gene Chr17:10165966-10197672 (-)
BALB/cJ MGP_BALBcJ_G0023118
 protein coding gene Chr17:10112258-10139631 (-)
C3H/HeJ MGP_C3HHeJ_G0022881
 protein coding gene Chr17:10415488-10444562 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023561
 protein coding gene Chr17:10902423-10935876 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021047
 protein coding gene Chr17:4083302-4110366 (+)
CAST/EiJ MGP_CASTEiJ_G0022395
 protein coding gene Chr17:10498077-10529581 (-)
CBA/J MGP_CBAJ_G0022853
 protein coding gene Chr17:11322778-11356047 (-)
DBA/2J MGP_DBA2J_G0022986
 protein coding gene Chr17:9978258-10006448 (-)
FVB/NJ MGP_FVBNJ_G0022956
 protein coding gene Chr17:9915441-9942753 (-)
LP/J MGP_LPJ_G0023058
 protein coding gene Chr17:10337792-10366108 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022975
 protein coding gene Chr17:10909289-10943579 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023587
 protein coding gene Chr17:10440539-10471567 (-)
PWK/PhJ MGP_PWKPhJ_G0022143
 protein coding gene Chr17:9667199-9694893 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021973
 protein coding gene Chr17:9875708-9902606 (-)
WSB/EiJ MGP_WSBEiJ_G0022452
 protein coding gene Chr17:10753298-10782171 (-)



Homology
more
  • Human Ortholog
    MAS1, MAS1 proto-oncogene, G protein-coupled receptor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAS1, MAS1 proto-oncogene, G protein-coupled receptor
  • Synonyms
    MAS, MGRA
  • Links
    NCBI Gene ID: 4142
    neXtProt AC: NX_P04201
    UniProt: P04201

  • Chr Location
    6q25.3; chr6:159888787-159917447 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene show enhanced long term potentiation and higher levels of anxiety. They are otherwise normal and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    935
  • Tissues
    74
  • cDNA Data
    9
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068037 Ensembl Gene Model | MGI Sequence Detail 27065 C57BL/6J ±  kb
    transcript ENSMUST00000089015 Ensembl | MGI Sequence Detail 2401 Not Applicable  
    polypeptide ENSMUSP00000086409 Ensembl | MGI Sequence Detail 324 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 7
      cDNA 11
      Primer pair 5
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12117, MGD-MRK-12118
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 54
    • Earliest
      J:902 Cebra-Thomas JA, et al., Localization of the Mas proto-oncogene to a densely marked region of mouse chromosome 17 associated with genomic imprinting [published erratum appears in Genomics 1992 Sep;14(1):208]. Genomics. 1992 Jun;13(2):444-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory