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Ascl1 Gene Detail
Summary
  • Symbol
    Ascl1
  • Name
    achaete-scute family bHLH transcription factor 1
  • Synonyms
    ASH1, bHLHa46, Mash1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96919
    NCBI Gene: 17172
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:87326681-87329522 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 43.64 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96919
 protein coding gene Chr10:87326681-87329522 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017618
 protein coding gene Chr10:88513938-88516779 (-)
A/J MGP_AJ_G0017597
 protein coding gene Chr10:85557588-85560431 (-)
AKR/J MGP_AKRJ_G0017555
 protein coding gene Chr10:87969339-87972182 (-)
BALB/cJ MGP_BALBcJ_G0017560
 protein coding gene Chr10:85828092-85830935 (-)
C3H/HeJ MGP_C3HHeJ_G0017383
 protein coding gene Chr10:87962284-87965127 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018017
 protein coding gene Chr10:91499229-91502070 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015699
 protein coding gene Chr10:81334608-81337472 (-)
CAST/EiJ MGP_CASTEiJ_G0016948
 protein coding gene Chr10:87851663-87854621 (-)
CBA/J MGP_CBAJ_G0017352
 protein coding gene Chr10:95278826-95281669 (-)
DBA/2J MGP_DBA2J_G0017458
 protein coding gene Chr10:84673629-84676472 (-)
FVB/NJ MGP_FVBNJ_G0017450
 protein coding gene Chr10:83909003-83911867 (-)
LP/J MGP_LPJ_G0017532
 protein coding gene Chr10:89198905-89201746 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017481
 protein coding gene Chr10:96813900-96816743 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018054
 protein coding gene Chr10:87807289-87810133 (-)
PWK/PhJ MGP_PWKPhJ_G0016729
 protein coding gene Chr10:84672750-84675718 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016517
 protein coding gene Chr10:86523401-86526275 (-)
WSB/EiJ MGP_WSBEiJ_G0017007
 protein coding gene Chr10:87773092-87775936 (-)



Homology
more
  • Human Ortholog
    ASCL1, achaete-scute family bHLH transcription factor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASCL1, achaete-scute family bHLH transcription factor 1
  • Synonyms
    ASH1, bHLHa46, HASH1, MASH1
  • Links
    NCBI Gene ID: 429
    neXtProt AC: NX_P50553
    UniProt: P50553

  • Chr Location
    12q23.2; chr12:102957674-102960513 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 4 alleles in 7 genetic backgrounds
    35 phenotypes from multigenic genotypes
    228 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants show impaired development of olfactory, sympathetic, parasympathetic, and enteric ganglia, lung neuroendocrine and adrenal chromaffin cells, and various brain centers, and die at birth with feeding and breathing problems.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    125
  • GO References
    49
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1780
  • Tissues
    451
  • cDNA Data
    43
  • Literature Summary
    607
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17172 NCBI Gene Model | MGI Sequence Detail 2842 C57BL/6J ±  kb
    transcript NM_008553 RefSeq | MGI Sequence Detail 2490 C57BL/6  
    polypeptide Q02067 UniProt | EBI | MGI Sequence Detail 231 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 104
      Genomic 2
      cDNA 58
      Primer pair 9
      Other 35

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12119, MGI:2143541
    References
    more
    • Summaries
      All 812
      Developmental Gene Expression 607
      Gene Ontology 49
      Phenotypes 228
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:358164 Rodarte KE, et al., Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1. Cancer Res. 2024 Nov 4;84(21):3522-3537
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory