Mertk MGI Mouse Gene Detail - MGI:96965 - MER proto-oncogene tyrosine kinase

Symbol

Mertk
Name

MER proto-oncogene tyrosine kinase
Synonyms

Eyk, Mer, nmf12, Nyk, Tyro 12

Feature Type

protein coding gene
IDs

MGI:96965
NCBI Gene: 17289
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

Chr2:128540876-128644814 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 62.63 cM
Mapping Data

3 experiments

SNPs within 2kb

2970 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96965	protein coding gene	Chr2:128540836-128645082 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026475	protein coding gene	Chr2:132054389-132160505 (+)
A/J	MGP_AJ_G0026439	protein coding gene	Chr2:126702532-126807487 (+)
AKR/J	MGP_AKRJ_G0026414	protein coding gene	Chr2:130299901-130401965 (+)
BALB/cJ	MGP_BALBcJ_G0026451	protein coding gene	Chr2:126966120-127068129 (+)
C3H/HeJ	MGP_C3HHeJ_G0026194	protein coding gene	Chr2:130812956-130916717 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026896	protein coding gene	Chr2:136171974-136284074 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024273	protein coding gene	Chr2:121529337-121634655 (+)
CAST/EiJ	MGP_CASTEiJ_G0025655	protein coding gene	Chr2:131051909-131159992 (+)
CBA/J	MGP_CBAJ_G0026174	protein coding gene	Chr2:141196890-141315814 (+)
DBA/2J	MGP_DBA2J_G0026308	protein coding gene	Chr2:126091699-126194410 (+)
FVB/NJ	MGP_FVBNJ_G0026272	protein coding gene	Chr2:124740818-124844455 (+)
LP/J	MGP_LPJ_G0026413	protein coding gene	Chr2:132276486-132386006 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026292	protein coding gene	Chr2:145149266-145259812 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026951	protein coding gene	Chr2:130331696-130444309 (+)
PWK/PhJ	MGP_PWKPhJ_G0025391	protein coding gene	Chr2:125665642-125770089 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025193	protein coding gene	Chr2:129437333-129554272 (+)
WSB/EiJ	MGP_WSBEiJ_G0025729	protein coding gene	Chr2:131241922-131352764 (+)

Human Ortholog

MERTK, MER proto-oncogene, tyrosine kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MERTK, MER proto-oncogene, tyrosine kinase
Synonyms

c-Eyk, c-mer, MER, RP38, Tyro12
Links

HGNC:7027

NCBI Gene ID: 10461

neXtProt AC: NX_Q12866

UniProt: Q12866
Chr Location

2q13; chr2:111898607-112029561 (+) GRCh38

MGI Vertebrate Homology

Mertk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MERTK
Gene Tree

Mertk

Diseases

1 with human MERTK associations

				Human Disease	Mouse Models
				retinitis pigmentosa 38 IDs retinitis pigmentosa 38 DOID:0110367 ICD10CM:H35.5 OMIM:613862

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

40 phenotypes from 4 alleles in 8 genetic backgrounds
50 phenotypes from multigenic genotypes
1 images
161 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

12
Gene trapped

1
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Mertk
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

65 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations show increased sensitivity to LPS-induced shock, defective phagocytosis of apoptotic cells, lupus-like autoimmunity, degeneration of photoreceptors, decreased platelet aggregation and protection from induced pulmonary thromboembolism and thrombosis.

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All GO Annotations

79
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

791
Tissues

53
cDNA Data

41
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MERTK

Xenbase mertk

ZFIN mertka

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All Sequences

42
RefSeq

8
UniProt

3
CCDS

CCDS16716.1

Ensembl

ENSMUSG00000014361 (Evidence)
NCBI Gene

17289

			Length	Strain/Species	Flank
genomic	ENSMUSG00000014361	Ensembl Gene Model \| MGI Sequence Detail	103939	C57BL/6J	± kb
transcript	ENSMUST00000014505	Ensembl \| MGI Sequence Detail	4302	Not Applicable
polypeptide	ENSMUSP00000014505	Ensembl \| MGI Sequence Detail	994	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010329 tyrosine-protein kinase Mer

(term hierarchy)
EC

2.7.10.1
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013151 Immunoglobulin

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050122 Receptor Tyrosine Kinase

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain
GlyGen

Q60805 16 sites, 10 N-linked glycans (4 sites)

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All nucleic 43

cDNA 42

Primer pair 1

Microarray probesets 4

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MGD-MRK-12199, MGI:2651818

Summaries

All 221

Developmental Gene Expression 14

Diseases 1

Gene Ontology 19

Phenotypes 161
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:352959 Olveda GE, et al., Microglial phagocytosis of single dying oligodendrocytes is mediated by CX3CR1 but not MERTK. Cell Rep. 2024 Jul 23;43(7):114385

TSS for Mertk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20060	Chr2:128540742-128540753 (+)	-128 bp
Tssr20061	Chr2:128540785-128540817 (+)	-75 bp
Tssr20062	Chr2:128540823-128540844 (+)	-42 bp
Tssr20063	Chr2:128546721-128546739 (+)	5,854 bp
Tssr20064	Chr2:128550636-128550654 (+)	9,769 bp
Tssr20065	Chr2:128550676-128550703 (+)	9,814 bp
Tssr20066	Chr2:128550975-128550985 (+)	10,104 bp
Tssr20067	Chr2:128551011-128551027 (+)	10,143 bp
Tssr20068	Chr2:128571211-128571225 (+)	30,342 bp
Tssr20069	Chr2:128580186-128580197 (+)	39,316 bp
Tssr648	Chr2:128593821-128593854 (+)	52,962 bp
Tssr20070	Chr2:128603734-128603738 (+)	62,860 bp
Tssr20071	Chr2:128611138-128611144 (+)	70,265 bp
Tssr20072	Chr2:128634293-128634312 (+)	93,427 bp
Tssr20073	Chr2:128638837-128638855 (+)	97,970 bp
Tssr20074	Chr2:128638861-128638892 (+)	98,001 bp
Tssr20075	Chr2:128639964-128639968 (+)	99,090 bp
Tssr20076	Chr2:128643731-128643742 (+)	102,861 bp
Tssr20077	Chr2:128643783-128643792 (+)	102,912 bp
Tssr20078	Chr2:128644216-128644228 (+)	103,346 bp
Tssr20079	Chr2:128644233-128644246 (+)	103,364 bp
Tssr20080	Chr2:128644300-128644318 (+)	103,433 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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