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Mmp12 Gene Detail
Summary
  • Symbol
    Mmp12
  • Name
    matrix metallopeptidase 12
  • Synonyms
    macrophage elastase, Mmel, MMP12
  • Feature Type
    protein coding gene
  • IDs
    MGI:97005
    NCBI Gene: 17381
  • Alliance
  • Transcription Start Sites
    62 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:7344397-7360461 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    480 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97005
protein coding gene Chr9:7344381-7369499 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034320
protein coding gene Chr9:4203272-4229802 (+)
A/J MGP_AJ_G0034297
protein coding gene Chr9:4286569-4311154 (+)
AKR/J MGP_AKRJ_G0034227
protein coding gene Chr9:4158044-4199326 (+)
BALB/cJ MGP_BALBcJ_G0034291
protein coding gene Chr9:4045380-4070410 (+)
C3H/HeJ MGP_C3HHeJ_G0034003
protein coding gene Chr9:4376048-4409597 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034813
protein coding gene Chr9:4361364-4392627 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031751
protein coding gene Chr9:3603147-3617623 (+)
CAST/EiJ MGP_CASTEiJ_G0033330
protein coding gene Chr9:4374520-4412218 (+)
CBA/J MGP_CBAJ_G0033975
protein coding gene Chr9:4463430-4490073 (+)
DBA/2J MGP_DBA2J_G0034132
protein coding gene Chr9:4174363-4220256 (+)
FVB/NJ MGP_FVBNJ_G0034077
protein coding gene Chr9:3966925-3991860 (+)
LP/J MGP_LPJ_G0034219
protein coding gene Chr9:4258797-4285514 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034121
protein coding gene Chr9:5179283-5205374 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034832
protein coding gene Chr9:4158915-4185560 (+)
PWK/PhJ MGP_PWKPhJ_G0033034
protein coding gene Chr9:4336025-4365906 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032871
protein coding gene Chr9:4432673-4463557 (+)
WSB/EiJ MGP_WSBEiJ_G0033446
protein coding gene Chr9:4171251-4200783 (+)



Homology
more
  • Human Ortholog
    MMP12, matrix metallopeptidase 12
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MMP12, matrix metallopeptidase 12
  • Synonyms
    HME, ME, MME, MMP-12
  • Links
    NCBI Gene ID: 4321
    neXtProt AC: NX_P39900
    UniProt: P39900

  • Chr Location
    11q22.2; chr11:102862736-102874982 (-)  GRCh38

Human Diseases
more
  • Diseases
    7 with human MMP12 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased sensitivity to cigarette smoke, decreased littler size, abnormal myelination, abnormal macrophage physiology, and decreased oligodedrocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17381 NCBI Gene Model | MGI Sequence Detail 16065 C57BL/6J ±  kb
transcript NM_001320076 RefSeq | MGI Sequence Detail 3665 ZRU/MplStud  
polypeptide P34960 UniProt | EBI | MGI Sequence Detail 473 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    Genomic 4
    cDNA 59
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12275, MGI:2143275
References
more
  • Summaries
    All 148
    Developmental Gene Expression 16
    Diseases 1
    Gene Ontology 8
    Phenotypes 77
  • Earliest
    J:11522 Denis M, et al., Tumor necrosis factor plays an essential role in determining hypersensitivity pneumonitis in a mouse model. Am J Respir Cell Mol Biol. 1991 Nov;5(5):477-83
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory