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Msn Gene Detail
Summary
  • Symbol
    Msn
  • Name
    moesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:97167
    NCBI Gene: 17698
  • Alliance
  • Transcription Start Sites
    58 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:95139651-95212159 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 42.65 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1445 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97167
protein coding gene ChrX:95139648-95212159 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035923
protein coding gene ChrX:92465910-92543857 (+)
A/J MGP_AJ_G0035909
protein coding gene ChrX:92644516-92716430 (+)
AKR/J MGP_AKRJ_G0035825
protein coding gene ChrX:95126963-95204716 (+)
BALB/cJ MGP_BALBcJ_G0035892
protein coding gene ChrX:91385287-91460143 (+)
C3H/HeJ MGP_C3HHeJ_G0035600
protein coding gene ChrX:92952708-93031693 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036421
protein coding gene ChrX:95392795-95469256 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033250
protein coding gene ChrX:90643635-90715231 (+)
CAST/EiJ MGP_CASTEiJ_G0034887
protein coding gene ChrX:77461625-77537769 (+)
CBA/J MGP_CBAJ_G0035576
protein coding gene ChrX:98284438-98363286 (+)
DBA/2J MGP_DBA2J_G0035730
protein coding gene ChrX:91836541-91911063 (+)
FVB/NJ MGP_FVBNJ_G0035668
protein coding gene ChrX:91239789-91314368 (+)
LP/J MGP_LPJ_G0035820
protein coding gene ChrX:93471375-93548390 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035703
protein coding gene ChrX:102555128-102630295 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036448
protein coding gene ChrX:92200037-92274176 (+)
PWK/PhJ MGP_PWKPhJ_G0034586
protein coding gene ChrX:75116551-75191254 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034415
protein coding gene ChrX:78282162-78363884 (+)
WSB/EiJ MGP_WSBEiJ_G0035026
protein coding gene ChrX:91036791-91114085 (+)



Homology
more
  • Human Ortholog
    MSN, moesin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MSN, moesin
  • Synonyms
    HEL70, IMD50
  • Links
    NCBI Gene ID: 4478
    neXtProt AC: NX_P26038
    UniProt: P26038

  • Chr Location
    Xq12; chrX:65588377-65741931 (+)  GRCh38

  • MGI Vertebrate Homology
    Msn stringent orthology
    1 human;1 mouse;1 rat;2 zebrafish
  • HCOP
    vertebrate homology predictions: MSN
  • Protein SuperFamily
    ERM
  • Gene Tree
    Msn
Human Diseases
more
  • Diseases
    1 with human MSN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous female and hemizygous male mutant mice develop normally and are fertile. No obvious histological abnormalities are reported.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17698 NCBI Gene Model | MGI Sequence Detail 72509 C57BL/6J ±  kb
    transcript NM_010833 RefSeq | MGI Sequence Detail 3840 Not Specified  
    polypeptide P26041 UniProt | EBI | MGI Sequence Detail 577 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 255
      cDNA 251
      Primer pair 1
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12566, MGI:2148057
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 27
      Gene Ontology 15
      Phenotypes 23
    • Earliest
      J:2811 Sato N, et al., A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites. J Cell Sci. 1992 Sep;103(Pt 1):131-43
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    11/12/2024
    MGI 6.24
    The Jackson Laboratory