About   Help   FAQ
Mt1 Gene Detail
Summary
  • Symbol
    Mt1
  • Name
    metallothionein 1
  • Synonyms
    Mt-1, MT-I
  • Feature Type
    protein coding gene
  • IDs
    MGI:97171
    NCBI Gene: 17748
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:94905710-94906955 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 46.34 cM
  • Mapping Data
    36 experiments
Strain
Comparison
more
  • SNPs within 2kb
    181 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97171
 protein coding gene Chr8:94905214-94906955 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033957
 protein coding gene Chr8:95580879-95582115 (+)
A/J MGP_AJ_G0033940
 protein coding gene Chr8:91861425-91862661 (+)
AKR/J MGP_AKRJ_G0033866
 protein coding gene Chr8:94381327-94382563 (+)
BALB/cJ MGP_BALBcJ_G0033932
 protein coding gene Chr8:91951854-91953090 (+)
C3H/HeJ MGP_C3HHeJ_G0033642
 protein coding gene Chr8:95083243-95084479 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034453
 protein coding gene Chr8:99076169-99077405 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031394
 protein coding gene Chr8:85668422-85669644 (+)
CAST/EiJ MGP_CASTEiJ_G0032974
 protein coding gene Chr8:94674813-94676049 (+)
CBA/J MGP_CBAJ_G0033618
 protein coding gene Chr8:102365663-102366899 (+)
DBA/2J MGP_DBA2J_G0033772
 protein coding gene Chr8:91331369-91332605 (+)
FVB/NJ MGP_FVBNJ_G0033719
 protein coding gene Chr8:90297402-90298638 (+)
LP/J MGP_LPJ_G0033864
 protein coding gene Chr8:95732337-95733573 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033761
 protein coding gene Chr8:104665611-104666847 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034471
 protein coding gene Chr8:94538783-94540019 (+)
PWK/PhJ MGP_PWKPhJ_G0032676
 protein coding gene Chr8:90694731-90695967 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032513
 protein coding gene Chr8:93363766-93365003 (+)
WSB/EiJ MGP_WSBEiJ_G0033086
 protein coding gene Chr8:95056712-95057948 (+)



Homology
more
  • Human Ortholog
    MT1A, metallothionein 1A
  • Vertebrate Orthologs
    12
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MT1A, metallothionein 1A
  • Synonyms
    MT1, MT-1A, MT1S, MTC, MT-IA
  • Links
    NCBI Gene ID: 4489
    neXtProt AC: NX_P04731
    UniProt: P04731

  • Chr Location
    16q13; chr16:56638666-56640087 (+)  GRCh38
  • Human Ortholog
    MT1B, metallothionein 1B
  • Synonyms
    MT1, MT-1B, MT1Q, MT-IB, MTP
  • Links
    NCBI Gene ID: 4490
    neXtProt AC: NX_P07438
    UniProt: P07438

  • Chr Location
    16q13; chr16:56651886-56653204 (+)  GRCh38
  • Human Ortholog
    MT1E, metallothionein 1E
  • Synonyms
    MT1, MT-1E, MTD, MT-IE
  • Links
    NCBI Gene ID: 4493
    neXtProt AC: NX_P04732
    UniProt: P04732

  • Chr Location
    16q13; chr16:56625475-56627112 (+)  GRCh38
  • Human Ortholog
    MT1F, metallothionein 1F
  • Synonyms
    MT1
  • Links
    NCBI Gene ID: 4494
    neXtProt AC: NX_P04733
    UniProt: P04733

  • Chr Location
    16q13; chr16:56657731-56660698 (+)  GRCh38
  • Human Ortholog
    MT1G, metallothionein 1G
  • Synonyms
    MT1, MT1K
  • Links
    NCBI Gene ID: 4495
    neXtProt AC: NX_P13640
    UniProt: P13640

  • Chr Location
    16q13; chr16:56666730-56668065 (-)  GRCh38
  • Human Ortholog
    MT1H, metallothionein 1H
  • Synonyms
    MT-0, MT1, MT-1H, MT-IH
  • Links
    NCBI Gene ID: 4496
    neXtProt AC: NX_P80294
    UniProt: P80294

  • Chr Location
    16q13; chr16:56669814-56671129 (+)  GRCh38
  • Human Ortholog
    MT1L, metallothionein 1L (pseudogene)
  • Synonyms
    MT1, MT1LP, MT1R, MTF
  • Links
    NCBI Gene ID: 4500

  • Chr Location
    16q13; chr16:56617461-56618818 (+)  GRCh38
  • Human Ortholog
    MT1M, metallothionein 1M
  • Synonyms
    MT1, MT1K, MT-1M, MT-IM
  • Links
    NCBI Gene ID: 4499
    neXtProt AC: NX_Q8N339
    UniProt: Q8N339

  • Chr Location
    16q13; chr16:56632659-56633981 (+)  GRCh38
  • Human Ortholog
    MT1X, metallothionein 1X
  • Synonyms
    MT1, MT-1l
  • Links
    NCBI Gene ID: 4501
    neXtProt AC: NX_P80297
    UniProt: P80297

  • Chr Location
    16q13; chr16:56682470-56684196 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human MT2A associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    88 phenotypes from multigenic genotypes
    150 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal zinc absorption and abnormal circadian rhythm response to melatonin. Mice homozygous for null alleles of Mt1 and Mt2 exhibit increased sensitivity to xenobiotics and injury with decreased wound healing and abnormal mineral aborption.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1075
  • Tissues
    144
  • cDNA Data
    321
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031765 Ensembl Gene Model | MGI Sequence Detail 1246 C57BL/6J ±  kb
    transcript ENSMUST00000212291 Ensembl | MGI Sequence Detail 633 Not Applicable  
    polypeptide ENSMUSP00000148443 Ensembl | MGI Sequence Detail 132 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 344
      Genomic 9
      cDNA 322
      Primer pair 7
      Other 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12573, MGD-MRK-12576
    References
    more
    • Summaries
      All 304
      Developmental Gene Expression 34
      Gene Ontology 10
      Phenotypes 150
    • Earliest
      J:6458 Durnam DM, et al., Isolation and characterization of the mouse metallothionein-I gene. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6511-5
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory