Mapt MGI Mouse Gene Detail - MGI:97180 - microtubule-associated protein tau

Symbol

Mapt
Name

microtubule-associated protein tau
Synonyms

Mtapt, Tau

Feature Type

protein coding gene
IDs

MGI:97180
NCBI Gene: 17762
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

Chr11:104122216-104222916 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 67.79 cM, cytoband E1
Mapping Data

7 experiments

SNPs within 2kb

554 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97180	protein coding gene	Chr11:104120235-104222916 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019274	protein coding gene	Chr11:107376860-107479744 (+)
A/J	MGP_AJ_G0019242	protein coding gene	Chr11:102807634-102905862 (+)
AKR/J	MGP_AKRJ_G0019211	protein coding gene	Chr11:105949314-106051521 (+)
BALB/cJ	MGP_BALBcJ_G0019216	protein coding gene	Chr11:103240093-103339811 (+)
C3H/HeJ	MGP_C3HHeJ_G0019025	protein coding gene	Chr11:106185510-106289290 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019666	protein coding gene	Chr11:110695767-110800246 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017291	protein coding gene	Chr11:100209588-100313372 (+)
CAST/EiJ	MGP_CASTEiJ_G0018579	protein coding gene	Chr11:107232469-107342480 (+)
CBA/J	MGP_CBAJ_G0018994	protein coding gene	Chr11:115285922-115401940 (+)
DBA/2J	MGP_DBA2J_G0019106	protein coding gene	Chr11:102297742-102397739 (+)
FVB/NJ	MGP_FVBNJ_G0019097	protein coding gene	Chr11:101830995-101936029 (+)
LP/J	MGP_LPJ_G0019175	protein coding gene	Chr11:107844931-107951562 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019127	protein coding gene	Chr11:114606546-114706026 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019703	protein coding gene	Chr11:106348404-106447811 (+)
PWK/PhJ	MGP_PWKPhJ_G0018343	protein coding gene	Chr11:103391842-103497595 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018134	protein coding gene	Chr11:106115662-106227459 (+)
WSB/EiJ	MGP_WSBEiJ_G0018628	protein coding gene	Chr11:106351470-106460115 (+)

Human Ortholog

MAPT, microtubule associated protein tau

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAPT, microtubule associated protein tau
Synonyms

DDPAC, FTD1, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, tau-40, Tau-PHF6
Links

HGNC:6893

NCBI Gene ID: 4137

neXtProt AC: NX_P10636

UniProt: P10636
Chr Location

17q21.31; chr17:45894527-46028334 (+) GRCh38

MGI Vertebrate Homology

Mapt stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MAPT
Gene Tree

Mapt

Diseases

9 with human MAPT associations

Human Disease

Mouse Models

Alzheimer's disease

IDs

View 2 models

dementia

IDs

frontotemporal dementia

IDs

late onset Parkinson's disease

IDs

Parkinson's disease

IDs

Pick's disease

IDs

progressive supranuclear palsy

IDs

tauopathy

IDs

temporal lobe epilepsy

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

3 with disease annotations

References

5 with disease annotations

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Phenotype Summary

23 phenotypes from 12 alleles in 11 genetic backgrounds
100 phenotypes from multigenic genotypes
1 images
488 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

286
Chemically induced (ENU)

1
Endonuclease-mediated

5
Gene trapped

224
Targeted

56
Genomic Mutations

6 involving Mapt
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

430 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous mutants exhibit altered performance in behavioral tests and show mircotubule changes in small-calibre axons. Embryonic hippocampal cultures from mutants exhibit delayed axonal and neuritic maturation.

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All GO Annotations

133
GO References

34

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1198
Tissues

131
cDNA Data

28
Literature Summary

83

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mapt

ZFIN mapta, maptb

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All Sequences

174
RefSeq

96
UniProt

10
CCDS

CCDS25527.1, CCDS25528.1

Ensembl

ENSMUSG00000018411 (Evidence)
NCBI Gene

17762

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018411	Ensembl Gene Model \| MGI Sequence Detail	100701	C57BL/6J	± kb
transcript	ENSMUST00000106989	Ensembl \| MGI Sequence Detail	2250	Not Applicable
polypeptide	ENSMUSP00000102602	Ensembl \| MGI Sequence Detail	749	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000010173 microtubule-associated protein tau

(term hierarchy)
PDB

6H0E, 8Q96
InterPro Domains

IPR027324 Microtubule associated protein MAP2/MAP4/Tau

IPR002955 Microtubule-associated protein Tau

IPR001084 Microtubule associated protein, tubulin-binding repeat
GlyGen

P10637 7 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (4 sites)

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All nucleic 34

Genomic 3

cDNA 28

Primer pair 3

Microarray probesets 9

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MGD-MRK-12590, MGD-MRK-14720, MGI:2144146, MGI:2144478

Summaries

All 825

Developmental Gene Expression 83

Diseases 5

Gene Ontology 34

Phenotypes 488
Earliest

J:17288 Drubin DG, et al., Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes. J Cell Biol. 1984 Mar;98(3):1090-7
Latest

J:358788 Zhao R, et al., Axo-axonic synaptic input drives homeostatic plasticity by tuning the axon initial segment structurally and functionally. Sci Adv. 2024 Aug 2;10(31):eadk4331

TSS for Mapt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105373	Chr11:104122268-104122279 (+)	58 bp
Tssr105374	Chr11:104122291-104122333 (+)	96 bp
Tssr105375	Chr11:104122343-104122354 (+)	133 bp
Tssr3695	Chr11:104122354-104122365 (+)	144 bp
Tssr105376	Chr11:104122400-104122403 (+)	186 bp
Tssr105377	Chr11:104173197-104173218 (+)	50,992 bp
Tssr105378	Chr11:104180430-104180445 (+)	58,222 bp
Tssr105379	Chr11:104186837-104186885 (+)	64,645 bp
Tssr105380	Chr11:104187289-104187294 (+)	65,076 bp
Tssr105381	Chr11:104197466-104197480 (+)	75,257 bp
Tssr105382	Chr11:104197513-104197524 (+)	75,303 bp
Tssr3696	Chr11:104197543-104197550 (+)	75,331 bp
Tssr105383	Chr11:104200521-104200536 (+)	78,313 bp
Tssr105384	Chr11:104200634-104200639 (+)	78,421 bp
Tssr105385	Chr11:104201154-104201167 (+)	78,945 bp
Tssr105386	Chr11:104201213-104201243 (+)	79,012 bp
Tssr105387	Chr11:104201306-104201317 (+)	79,096 bp
Tssr105388	Chr11:104212169-104212185 (+)	89,961 bp
Tssr105389	Chr11:104219402-104219424 (+)	97,197 bp
Tssr105390	Chr11:104220593-104220610 (+)	98,386 bp
Tssr3697	Chr11:104220743-104220754 (+)	98,533 bp
Tssr105391	Chr11:104220783-104220795 (+)	98,573 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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