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Myog Gene Detail
Summary
  • Symbol
    Myog
  • Name
    myogenin
  • Synonyms
    bHLHc3, myo
  • Feature Type
    protein coding gene
  • IDs
    MGI:97276
    NCBI Gene: 17928
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:134217742-134220286 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 58.18 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97276
 protein coding gene Chr1:134217727-134220286 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016502
 protein coding gene Chr1:137938129-137940688 (+)
A/J MGP_AJ_G0016485
 protein coding gene Chr1:132752808-132755367 (+)
AKR/J MGP_AKRJ_G0016450
 protein coding gene Chr1:136711998-136714557 (+)
BALB/cJ MGP_BALBcJ_G0016445
 protein coding gene Chr1:133086865-133089424 (+)
C3H/HeJ MGP_C3HHeJ_G0016271
 protein coding gene Chr1:136812751-136815310 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016906
 protein coding gene Chr1:142970311-142972870 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014617
 protein coding gene Chr1:125894698-125897316 (+)
CAST/EiJ MGP_CASTEiJ_G0015851
 protein coding gene Chr1:135861843-135864402 (+)
CBA/J MGP_CBAJ_G0016244
 protein coding gene Chr1:147919411-147921970 (+)
DBA/2J MGP_DBA2J_G0016350
 protein coding gene Chr1:131764245-131766804 (+)
FVB/NJ MGP_FVBNJ_G0016349
 protein coding gene Chr1:130390821-130393380 (+)
LP/J MGP_LPJ_G0016421
 protein coding gene Chr1:139218591-139221150 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016374
 protein coding gene Chr1:153622227-153624786 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016942
 protein coding gene Chr1:136441968-136444527 (+)
PWK/PhJ MGP_PWKPhJ_G0015637
 protein coding gene Chr1:130781813-130784452 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015424
 protein coding gene Chr1:135407720-135410271 (+)
WSB/EiJ MGP_WSBEiJ_G0015914
 protein coding gene Chr1:136473765-136476326 (+)



Homology
more
  • Human Ortholog
    MYOG, myogenin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYOG, myogenin
  • Synonyms
    bHLHc3, myf-4, MYF4
  • Links
    NCBI Gene ID: 4656
    neXtProt AC: NX_P15173
    UniProt: P15173

  • Chr Location
    1q32.1; chr1:203083129-203086012 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 5 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit a severe reduction in muscle mass associated with delayed primary myogenesis and very little secondary myofiber formation, defects of the thoracic skeleton, and perinatal death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1820
  • Tissues
    385
  • cDNA Data
    56
  • Literature Summary
    391
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17928 NCBI Gene Model | MGI Sequence Detail 2545 C57BL/6J ±  kb
    transcript NM_031189 RefSeq | MGI Sequence Detail 1518 Not Specified  
    polypeptide P12979 UniProt | EBI | MGI Sequence Detail 224 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 159
      Genomic 5
      cDNA 76
      Primer pair 38
      Other 40

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12775
    References
    more
    • Summaries
      All 527
      Developmental Gene Expression 391
      Gene Ontology 35
      Phenotypes 36
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:358347 Dias AP, et al., Tail-anchored membrane protein SLMAP3 is essential for targeting centrosomal proteins to the nuclear envelope in skeletal myogenesis. Open Biol. 2024 Oct;14(10):240094
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory