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Nedd8 Gene Detail
Summary
  • Symbol
    Nedd8
  • Name
    neural precursor cell expressed, developmentally down-regulated gene 8
  • Synonyms
    Rub1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97301
    NCBI Gene: 18002
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55899720-55909337 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    244 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97301
 protein coding gene Chr14:55899720-55909581 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021361
 protein coding gene Chr14:49703972-49713613 (-)
A/J MGP_AJ_G0021320
 protein coding gene Chr14:48711952-48721593 (-)
AKR/J MGP_AKRJ_G0021296
 protein coding gene Chr14:50459594-50469235 (-)
BALB/cJ MGP_BALBcJ_G0021324
 protein coding gene Chr14:48671029-48680670 (-)
C3H/HeJ MGP_C3HHeJ_G0021104
 protein coding gene Chr14:50143186-50152827 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021762
 protein coding gene Chr14:52193461-52203114 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019309
 protein coding gene Chr14:47086583-47094064 (-)
CAST/EiJ MGP_CASTEiJ_G0020623
 protein coding gene Chr14:46412399-46422090 (-)
CBA/J MGP_CBAJ_G0021071
 protein coding gene Chr14:53760705-53770345 (-)
DBA/2J MGP_DBA2J_G0021192
 protein coding gene Chr14:48435181-48444856 (-)
FVB/NJ MGP_FVBNJ_G0021174
 protein coding gene Chr14:47883534-47893205 (-)
LP/J MGP_LPJ_G0021266
 protein coding gene Chr14:50750687-50760328 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021198
 protein coding gene Chr14:53114154-53123825 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021789
 protein coding gene Chr14:49646304-49655945 (-)
PWK/PhJ MGP_PWKPhJ_G0020370
 protein coding gene Chr14:44968100-44977741 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020198
 protein coding gene Chr14:45653636-45663113 (-)
WSB/EiJ MGP_WSBEiJ_G0020676
 protein coding gene Chr14:49932057-49941718 (-)



Homology
more
  • Human Ortholog
    NEDD8, NEDD8 ubiquitin like modifier
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEDD8, NEDD8 ubiquitin like modifier
  • Synonyms
    NEDD-8
  • Links
    NCBI Gene ID: 4738
    neXtProt AC: NX_Q15843
    UniProt: Q15843

  • Chr Location
    14q12; chr14:24216857-24232367 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    35
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    29
  • Targeted
    2
  • Genomic Mutations
    1 involving Nedd8
  • Find Mice (IMSR)
    7 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    835
  • Tissues
    96
  • cDNA Data
    141
  • Literature Summary
    12
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 18002 NCBI Gene Model | MGI Sequence Detail 9618 C57BL/6J ±  kb
transcript NM_008683 RefSeq | MGI Sequence Detail 580 ZRU/MplStud  
polypeptide P29595 UniProt | EBI | MGI Sequence Detail 81 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 146
    Genomic 4
    cDNA 142

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12814
References
more
  • Summaries
    All 58
    Developmental Gene Expression 12
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
  • Latest
    J:346004 Jiang Y, et al., Targeting NEDD8 suppresses surgical stress-facilitated metastasis of colon cancer via restraining regulatory T cells. Cell Death Dis. 2024 Jan 5;15(1):8
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory