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Notch2 Gene Detail
Summary
  • Symbol
    Notch2
  • Name
    notch 2
  • Synonyms
    Motch B, N2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97364
    NCBI Gene: 18129
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:97920854-98057683 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 42.42 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3526 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97364
 protein coding gene Chr3:97920843-98057683 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027647
 protein coding gene Chr3:98995089-99135666 (+)
A/J MGP_AJ_G0027609
 protein coding gene Chr3:95818356-95956393 (+)
AKR/J MGP_AKRJ_G0027576
 protein coding gene Chr3:98114708-98253006 (+)
BALB/cJ MGP_BALBcJ_G0027619
 protein coding gene Chr3:95622169-95759999 (+)
C3H/HeJ MGP_C3HHeJ_G0027351
 protein coding gene Chr3:98379714-98516126 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028065
 protein coding gene Chr3:102666486-102809405 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025407
 protein coding gene Chr3:92074117-92210420 (+)
CAST/EiJ MGP_CASTEiJ_G0026806
 protein coding gene Chr3:97678842-97824110 (+)
CBA/J MGP_CBAJ_G0027326
 protein coding gene Chr3:106328161-106475418 (+)
DBA/2J MGP_DBA2J_G0027469
 protein coding gene Chr3:95130611-95267484 (+)
FVB/NJ MGP_FVBNJ_G0027438
 protein coding gene Chr3:93121957-93261024 (+)
LP/J MGP_LPJ_G0027574
 protein coding gene Chr3:100257334-100399814 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027464
 protein coding gene Chr3:112399698-112543392 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028119
 protein coding gene Chr3:97739282-97880506 (+)
PWK/PhJ MGP_PWKPhJ_G0026531
 protein coding gene Chr3:95023478-95162790 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026353
 protein coding gene Chr3:96014908-96153001 (+)
WSB/EiJ MGP_WSBEiJ_G0026884
 protein coding gene Chr3:98176643-98318321 (+)



Homology
more
  • Human Ortholog
    NOTCH2, notch receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOTCH2, notch receptor 2
  • Synonyms
    AGS2, HJCYS, hN2
  • Links
    NCBI Gene ID: 4853
    neXtProt AC: NX_Q04721
    UniProt: Q04721

  • Chr Location
    1p12; chr1:119911553-120100779 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Notch2 mouse models; 2 with human NOTCH2 associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
 View 1 model
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    157 phenotypes from 18 alleles in 24 genetic backgrounds
    60 phenotypes from multigenic genotypes
    204 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null alleles exhibit defects in embryonic development resulting in embryonic or neonatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    97
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1984
  • Tissues
    410
  • cDNA Data
    21
  • Literature Summary
    252
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18129 NCBI Gene Model | MGI Sequence Detail 136830 C57BL/6J ±  kb
    transcript NM_010928 RefSeq | MGI Sequence Detail 10506 ZRU/MplStud  
    polypeptide O35516 UniProt | EBI | MGI Sequence Detail 2473 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 1
      cDNA 30
      Primer pair 16
      Other 18

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12916, MGI:2139830
    References
    more
    • Summaries
      All 517
      Developmental Gene Expression 252
      Diseases 6
      Gene Ontology 25
      Phenotypes 204
    • Earliest
      J:34445 Weinmaster G, et al., Notch2: a second mammalian Notch gene. Development. 1992 Dec;116(4):931-41
    • Latest
      J:355651 El Azhar Y, et al., Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking. Development. 2024 Sep 15;151(18):dev202936
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory