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Ntrk1 Gene Detail
Summary
  • Symbol
    Ntrk1
  • Name
    neurotrophic tyrosine kinase, receptor, type 1
  • Synonyms
    Tkr, TrkA
  • Feature Type
    protein coding gene
  • IDs
    MGI:97383
    NCBI Gene: 18211
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:87685551-87702469 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 38.62 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    386 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97383
 protein coding gene Chr3:87685551-87702549 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027368
 protein coding gene Chr3:87902105-87919023 (-)
A/J MGP_AJ_G0027332
 protein coding gene Chr3:84919026-84935956 (-)
AKR/J MGP_AKRJ_G0027298
 protein coding gene Chr3:86973134-86990054 (-)
BALB/cJ MGP_BALBcJ_G0027341
 protein coding gene Chr3:85015256-85032176 (-)
C3H/HeJ MGP_C3HHeJ_G0027084
 protein coding gene Chr3:87268729-87285673 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027787
 protein coding gene Chr3:91128466-91145384 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025140
 protein coding gene Chr3:80539165-80556027 (-)
CAST/EiJ MGP_CASTEiJ_G0026531
 protein coding gene Chr3:87487482-87504442 (-)
CBA/J MGP_CBAJ_G0027059
 protein coding gene Chr3:94206776-94226301 (-)
DBA/2J MGP_DBA2J_G0027195
 protein coding gene Chr3:84402389-84419672 (-)
FVB/NJ MGP_FVBNJ_G0027164
 protein coding gene Chr3:82682496-82699420 (-)
LP/J MGP_LPJ_G0027303
 protein coding gene Chr3:88863277-88881164 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027183
 protein coding gene Chr3:100477251-100495030 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027845
 protein coding gene Chr3:86748627-86766828 (-)
PWK/PhJ MGP_PWKPhJ_G0026264
 protein coding gene Chr3:84206328-84223608 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026081
 protein coding gene Chr3:85937604-85954588 (-)
WSB/EiJ MGP_WSBEiJ_G0026610
 protein coding gene Chr3:87112049-87128991 (-)



Homology
more
  • Human Ortholog
    NTRK1, neurotrophic receptor tyrosine kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NTRK1, neurotrophic receptor tyrosine kinase 1
  • Synonyms
    MTC, p140-TrkA, TRK, TRK1, Trk-A, TRKA
  • Links
    NCBI Gene ID: 4914
    neXtProt AC: NX_P04629
    UniProt: P04629

  • Chr Location
    1q23.1; chr1:156815636-156881850 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ntrk1 mouse models; 4 with human NTRK1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 11 alleles in 9 genetic backgrounds
    8 phenotypes from multigenic genotypes
    3 images
    111 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutations result in premature death due to severe sensory and sympathetic neuropathies. A conditional mutant mouse exhibits defects in mast cell and B cell physiology. Homozygotes for a point mutation are normal, but are subject to pharmacological control of signalling. Homozygosity for the p.R685A mutation affects sympathetic neuron development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    185
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1303
  • Tissues
    228
  • cDNA Data
    23
  • Literature Summary
    241
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028072 Ensembl Gene Model | MGI Sequence Detail 16919 C57BL/6J ±  kb
    transcript ENSMUST00000029712 Ensembl | MGI Sequence Detail 2588 Not Applicable  
    polypeptide ENSMUSP00000029712 Ensembl | MGI Sequence Detail 799 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000011469 high affinity nerve growth factor receptor
      (term hierarchy)
    • EC
      2.7.10.1
    • InterPro Domains
      IPR020777 Growth factor receptor NTRK
      IPR031635 Growth factor receptor NTRK, leucine rich repeat C-terminal
      IPR020461 High affinity nerve growth factor receptor NTRK1
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050122 Receptor Tyrosine Kinase
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
    • GlyGen
      Q3UFB7 11 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 1
      cDNA 27
      Primer pair 7
      Other 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12942, MGD-MRK-15125, MGI:2140079
    References
    more
    • Summaries
      All 433
      Developmental Gene Expression 241
      Diseases 3
      Gene Ontology 31
      Phenotypes 111
    • Earliest
      J:10104 Klein R, et al., trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 1989 Dec 1;8(12):3701-9
    • Latest
      J:354315 Lowenstein ED, et al., Molecular Characterization of Nodose Ganglia Development Reveals a Novel Population of Phox2b+ Glial Progenitors in Mice. J Neurosci. 2024 Jul 10;44(28)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory