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Pgd Gene Detail
Summary
  • Symbol
    Pgd
  • Name
    phosphogluconate dehydrogenase
  • Synonyms
    0610042A05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:97553
    NCBI Gene: 110208
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:149234448-149251162 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 78.96 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97553
 protein coding gene Chr4:149234448-149251228 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029136
 protein coding gene Chr4:152968417-152985170 (-)
A/J MGP_AJ_G0029101
 protein coding gene Chr4:146590381-146607099 (-)
AKR/J MGP_AKRJ_G0029049
 protein coding gene Chr4:150608682-150625391 (-)
BALB/cJ MGP_BALBcJ_G0029117
 protein coding gene Chr4:147100959-147117725 (-)
C3H/HeJ MGP_C3HHeJ_G0028838
 protein coding gene Chr4:151169968-151186677 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029566
 protein coding gene Chr4:158491899-158508679 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026812
 protein coding gene Chr4:139016092-139034312 (-)
CAST/EiJ MGP_CASTEiJ_G0028251
 protein coding gene Chr4:148391796-148410847 (-)
CBA/J MGP_CBAJ_G0028800
 protein coding gene Chr4:163148449-163165337 (-)
DBA/2J MGP_DBA2J_G0028949
 protein coding gene Chr4:146710826-146727538 (-)
FVB/NJ MGP_FVBNJ_G0028913
 protein coding gene Chr4:145810159-145828777 (-)
LP/J MGP_LPJ_G0029039
 protein coding gene Chr4:152905690-152922457 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028940
 protein coding gene Chr4:166388339-166405055 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029598
 protein coding gene Chr4:151101346-151118062 (-)
PWK/PhJ MGP_PWKPhJ_G0027971
 protein coding gene Chr4:142705856-142722792 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027805
 protein coding gene Chr4:145338312-145356787 (-)
WSB/EiJ MGP_WSBEiJ_G0028331
 protein coding gene Chr4:151258608-151275378 (-)



Homology
more
  • Human Ortholog
    PGD, phosphogluconate dehydrogenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGD, phosphogluconate dehydrogenase
  • Synonyms
    6PGD
  • Links
    NCBI Gene ID: 5226
    neXtProt AC: NX_P52209
    UniProt: P52209

  • Chr Location
    1p36.22; chr1:10398592-10420511 (+)  GRCh38
  • MGI Vertebrate Homology
    Pgd stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: PGD
  • Protein SuperFamily
    6PGD
  • Gene Tree
    Pgd
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
T-cell specific knock-out results in more robust development of effector functions in stimulated nave CD8+ T cells. Mice homozygous for a conditional allele activated in T cells exhibit enlarged peripheral lymphoid organs, splenomegaly, lymphoproliferation of CD4/CD8 T-cells, and super high IFN, IL-17A, IL-4, and IL-5 levels in serum with reduced injected tumor cell growth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    918
  • Tissues
    106
  • cDNA Data
    224
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110208 NCBI Gene Model | MGI Sequence Detail 16715 C57BL/6J ±  kb
    transcript NM_001081274 RefSeq | MGI Sequence Detail 2227 ZRU/MplStud  
    polypeptide Q9DCD0 UniProt | EBI | MGI Sequence Detail 483 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000012604 6-phosphogluconate dehydrogenase, decarboxylating
      (term hierarchy)
    • EC
      1.1.1.43, 1.1.1.44
    • InterPro Domains
      IPR006184 6-phosphogluconate-binding site
      IPR006183 6-phosphogluconate dehydrogenase
      IPR006114 6-phosphogluconate dehydrogenase, C-terminal
      IPR006113 6-phosphogluconate dehydrogenase, decarboxylating
      IPR013328 6-phosphogluconate dehydrogenase, domain 2
      IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
      IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
      IPR036291 NAD(P)-binding domain superfamily
    • GlyGen
      Q9DCD0 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 226
      cDNA 226

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13255, MGI:1914101, MGI:2140453, MGI:2140666
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 6
      Gene Ontology 15
      Phenotypes 13
    • Earliest
      J:322163 Gumaa KA, et al., The pentose phosphate pathway of glucose metabolism. Enzyme profiles and transient and steady-state content of intermediates of alternative pathways of glucose metabolism in Krebs ascites cells. Biochem J. 1969 Dec;115(5):1009-29
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory